Chemical and pharmacological characterization of anthelmintic benzimidazoles

Kelemen Hajnal; Mărcuțiu Petra Edina; Rausz Adrienn; Papp Lajos-Attila

doi:10.2478/orvtudert-2021-0013

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Chemical and pharmacological characterization of anthelmintic benzimidazoles

Bulletin of Medical Sciences

Volume 94 (2021): Issue 2 (December 2021)

By: Kelemen Hajnal, Mărcuțiu Petra Edina, Rausz Adrienn and Papp Lajos-Attila

Open Access

|Oct 2022

Abstract

Benzimidazoles, which interfere with the complex life cycle of worms, are essential in the treatment of helminthiasis. Four benzimidazole antihelmintics have been used in human therapy: albendazole, mebendazole, thiabendazole, triclabendazole. The history, representatives, synthesis, physicochemical properties, structure-activity relationships of anthelmintic benzimidazoles are presented in the review, as well as the pharmacological properties and mechanism of action of these agents.

In the last decade, benzimidazole carbamate-structured anthelmintics have also been studied for their antitumor activity.

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Articles in this issue

DOI: https://doi.org/10.2478/orvtudert-2021-0013 | Journal eISSN: 2537-5059 | Journal ISSN: 1453-0953

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Language: English

Page range: 88 - 96

Published on: Oct 31, 2022

Published by: Transylvanian Museum Society

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

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© 2022 Kelemen Hajnal, Mărcuțiu Petra Edina, Rausz Adrienn, Papp Lajos-Attila, published by Transylvanian Museum Society
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Volume 94 (2021): Issue 2 (December 2021)