The clinically important anaerobic, human pathogenic Bacteroides species and their antibiotic resistance levels in Central and Southeast Europe

József, Sóki; Edit, és Székely

doi:10.2478/orvtudert-2018-0003

Abstract

The Bacteroides and Parabacteroides species are important obligate anaerobic bacteria that are significant constituents of normal flora (microbiota), and opportunistic pathogens with special biological background. They are highly resistant to antibiotics and monitoring their resistance levels is important for their empiric therapy. Several antibiotic resistance studies were conducted in the USA and Europe and we have data for the region involved in this study showing comparable trends. Multidrug-resistant strains are emerging among Bacteroides too, where the proper antibiotic tests and treatments may be life-saving.

References

1. Wexler HM. Bacteroides: the good, the bad and the nittygritty. Clin Microbiol Rev. 2007;20(4):593-621.10.1128/CMR.00008-07217604517934076
Search in Google Scholar Back to article
2. Könönen E, Wade WG, Citron DM. Bacteroides, Porphyromonas, Prevotella, Fusobacterium, and other anaerobic Gram-negative rods. Manual of Clinical Microbiology, 10th Edition: American Society of Microbiology; 2011.10.1128/9781555816728.ch51
Search in Google Scholar Back to article
3. Nagy E. Anaerobic infections: Update on treatment considerations. Drugs. 2010;70(7):841-58.10.2165/11534490-000000000-000002042649620426496
Open DOI Search in Google Scholar Back to article
4. Sóki J. Extended role for insertion sequence elements in the antibiotic resistance of Bacteroides. World Journal of Clinical Infectious Diseases. 2013;3(1):1-12.10.5495/wjcid.v3.i1
Open DOI Search in Google Scholar Back to article
5. Sóki J, Wareham DW, Rátkai C, Aduse-Opoku J, Urbán E, Nagy E. Prevalence, nucleotide sequence and expression studies of two proteins of a 5.6 kb, Class III, Bacteroides plasmid frequently found in clinical isolates from European countries. Plasmid. 2010;63(2):86-97.10.1016/j.plasmid.2009.12.00220026106
Open DOI Search in Google Scholar Back to article
6. Rasmussen BA, Bush K, Tally FP. Antimicrobial resistance in Bacteroides. Clinical Infectious Diseases. 1993;16:S390-400.10.1093/clinids/16.Supplement_4.S3908324154
Open DOI Search in Google Scholar Back to article
7. Clinical breakpoints [database on the Internet]. European Committee on Antimicrobial Susceptibility Testing (EUCAST). 2015-01. Available from: www.eucast.org/clinical:beakpoints/.
Search in Google Scholar Back to article
8. Methods for antimicrobial susceptibility testing of anaerobic bacteria, Approved Standard, Document M11-A8 Clinical Laboratory Standards Institute, Wayne PA,; 2012.
Search in Google Scholar Back to article
9. Nagy E, Justesen US, Eitel Z, Urbán E. Development of EUCAST disk diffusion method for susceptibility testing of the Bacteroides fragilis group isolates. Anaerobe. 2015;31:65-71.10.1016/j.anaerobe.2014.10.00825464140
Search in Google Scholar Back to article
10. Nagy E, Maier T, Urban E, Terhes G, Kostrzewa M. Species identification of clinical isolates of Bacteroides by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry. Clinical Microbiology and Infection. 2009;15(8):796-802.10.1111/j.1469-0691.2009.02788.x19438622
Search in Google Scholar Back to article
11. Nagy E, Becker S, Sóki J, Urbán E, Kostrzewa M. Differentiation of division I (cfiA-negative) and division II (cfiA-positive) Bacteroides fragilis strains by matrix-assisted laser desorption/ionization time of-flight mass spectrometry. Journal of Medical Microbiology. 2011;60(11):1584-90.10.1099/jmm.0.031336-021680764
Search in Google Scholar Back to article
12. Johansson Å, Nagy E, Sóki J. Detection of carbapenemase activities of Bacteroides fragilis strains with matrix-assisted laser desorption ionization – Time of flight mass spectrometry (MALDI-TOF MS). Anaerobe. 2014;26:49-52.10.1016/j.anaerobe.2014.01.00624480431
Search in Google Scholar Back to article
13. Snydman DR, Jacobus NV, McDermott LA, Ruthazer R, Golan Y, Goldstein EJC, et al. National survey on the susceptibility of Bacteroides fragilis group: report and analysis of trends in the United States from 1997-2004. Antimicrobial Agents and Chemotherapy. 2007;51(5):1649-55.10.1128/AAC.01435-06185553217283189
Search in Google Scholar Back to article
14. Snydman DR, Jacobus NV, McDermott LA, Golan Y, Goldstein EJC, Harrell L, et al. Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006–2009. Anaerobe. 2011;17(4):147-51.10.1016/j.anaerobe.2011.05.01421664469
Search in Google Scholar Back to article
15. Snydman DR, Jacobus NV, McDermott LA, Golan Y, Hecht DW, Goldstein EJC, et al. Lessons learned from the anaerobe survey: Historical perspective and review of most recent data (2005-2007). Clinical Infectious Diseases. 2010;50(Suppl1):S26-33.10.1086/64794020067390
Search in Google Scholar Back to article
16. Philips I, King A, Nord CE, Hoffstedt B on behalf of the ESCMID Study Group on Antimicrobial Resistance of Anaerobic Bacteria. Antibiotic sensitivity of Bacteroides fragilis group in Europe. European Journal of Clinical Microbiology & Infectious Diseases. 1992;11(4):292-304.10.1007/BF019620681396748
Search in Google Scholar Back to article
17. Hedberg M, Nord CE on behalf of the ESCMID Study Group on Antimicrobial Resistance of Anaerobic Bacteria. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe. Clinical Microbiology and Infection. 2003;9(6):475-88.10.1046/j.1469-0691.2003.00674.x12848722
Search in Google Scholar Back to article
18. Nagy E, Urbán E, Nord CE on behalf of the ESCMID Study Group on Antimicrobial Resistance of Anaerobic Bacteria. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe 20 years of experience. Clinical Microbiology and Infection. 2011;17(3):371-9.10.1111/j.1469-0691.2010.03256.x20456453
Search in Google Scholar Back to article
19. Labbé A-C, Bourgault A-M, Vincelette J, Turgeon PL, Lamothe F. Trends in antimicrobial resistance among clinical isolates of the Bacteroides fragilis group from 1992 to 1997 in Montreal, Canada. Antimicrobial Agents and Chemotherapy. 1999;43(10):2517-9.10.1128/AAC.43.10.25178951110508035
Search in Google Scholar Back to article
20. Wybo I, Van den Bossche D, Soetens O, Vekens E, Vandoorslaer K, Claeys G, et al. Fourth Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria. Journal of Antimicrobial Chemotherapy. 2014 January 1, 2014;69(1):155-61.10.1093/jac/dkt344
Search in Google Scholar Back to article
21. Boyanova L, Kolarov R, Mitov I. Recent evolution of antibiotic resistance in the anaerobes as compared to previous decades. Anaerobe. 2015;31:4-10.10.1016/j.anaerobe.2014.05.00424875330
Search in Google Scholar Back to article
22. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical Microbiology and Infection. 2012;18(3):268-81.10.1111/j.1469-0691.2011.03570.x21793988
Open DOI Search in Google Scholar Back to article
23. Hartmeyer GN, Sóki J, Nagy E, Justesen US. Multidrugresistant Bacteroides fragilis group on the rise in Europe? Journal of medical microbiology. 2012 December 1, 2012;61(Pt 12):1784-8.10.1099/jmm.0.049825-0
Search in Google Scholar Back to article
24. Katsandri A, Papaparaskevas J, Pantazatou A, Petrikkos GL, Thomopoulos G, Houhoula DP, et al. Two cases of infections due to multidrug-resistant Bacteroides fragilis group strains. Journal of Clinical Microbiology. 2006 September 1, 2006;44(9):3465-7.10.1128/JCM.00316-06
Search in Google Scholar Back to article
25. Urbán E, Horváth Z, Sóki J, Lázár G. First Hungarian case of an infection caused by multidrug-resistant Bacteroides fragilis strain. Anaerobe. 2015;31(0):55-8.10.1016/j.anaerobe.2014.09.01925285854
Search in Google Scholar Back to article
26. Cuchural G. J.; Tally FPJ, N. V.; Cleary, T.; Finegold, S. M.; Hill, G.; Iannini, P.; O’Keefe, P. O.; Pierson, C. Comparative activities od newer β-lactam agents against members of the Bacteroides fragilis group. Antimicrobial Agents and Chemotherapy. 1990;34(3):479-80.10.1128/AAC.34.3.4791716202334161
Open DOI Search in Google Scholar Back to article
27. Snydman DR, Jacobus NV, McDermott LA. Evaluation of the in vitro activities of doripenem, a new broad spectrum carbapenem, against recent clinical anaerobic isolates with emphasis on the Bacteroides fragilis group. Antimicrobial Agents and Chemotherapy. 2008(Journal Article).10.1128/AAC.00696-08259288518838581
Search in Google Scholar Back to article
28. Marina M, Ivanova M, Kantardjiev T. Antimicrobial susceptibility of anaerobic bacteria in Bulgaria. Anaerobe. 2009;15(4):127-32.10.1016/j.anaerobe.2009.03.00219292999
Search in Google Scholar Back to article
29. Nagy E, Szőke I, Gacs M, Csiszár K. Antibiotic susceptibility of Bacteroides fragilis group strains in Hungary. Anaerobe. 1995 1995/10/01;1(5):269-74.10.1006/anae.1995.102616887535
Search in Google Scholar Back to article
30. Papaparaskevas J, Pantazatou A, Katsandri A, Legakis NJ, Avlamis A. Multicentre survey of the in-vitro activity of seven antimicrobial agents, including ertapenem, against recently isolated Gram-negative anaerobic bacteria in Greece. Clinical Microbiology and Infection. 2005;11(10):820-4.10.1111/j.1469-0691.2005.01233.x16153256
Search in Google Scholar Back to article
31. Papaparaskevas J, Pantazatou A, Katsandri A, Houhoula DP, Legakis NJ, Tsakris A, et al. Moxifloxacin resistance is prevalent among Bacteroides and Prevotella species in Greece. Journal of Antimicrobial Chemotherapy. 2008;62(1):137-41.10.1016/j.ijantimicag.2007.10.003
Open DOI Search in Google Scholar Back to article
32. Grisold AJ, Wendelin I, Presterl E, Raggam RB, Masoud L, Badura A, et al. In vitro activity of ten antibiotics, including tigecycline, against Bacteroides species in Austria. European Journal of Clinical Microbiology & Infectious Diseases. [journal article]. 2007;26(7):525-7.10.1007/s10096-007-0318-017562088
Open DOI Search in Google Scholar Back to article
33. Novak A, Rubic Z, Dogas V, Goic-Barisic I, Radic M, Tonkic M. Antimicrobial susceptibility of clinically isolated anaerobic bacteria in a University Hospital Centre Split, Croatia in 2013. Anaerobe. 2015;31:31-6.10.1016/j.anaerobe.2014.10.01025479237
Search in Google Scholar Back to article
34. Székely E, Eitel Z, Molnár S, Szász IÉ, Bilca D, Sóki J. Analysis of Romanian Bacteroides isolates for antibiotic resistance levels and the corresponding antibiotic resistance genes. Anaerobe. 2015;31:11-4.10.1016/j.anaerobe.2014.09.00125218409
Search in Google Scholar Back to article
35. Kierzkowska M, Majewska A, Sawicka-Grzelak A, Mlynarczyk A, Chmura A, Kwiatkowski A, et al. Antibiotic resistance profiles of strictly anaerobic Gram-negative Bacteroides spp. and Parabacteroides spp. bacilli isolated from infected inpatients on surgical wards. Journal of Global Antimicrobial Resistance. 2016;7:128-9.10.1016/j.jgar.2016.09.00127770692
Search in Google Scholar Back to article
36. Jeverica S, Kolenc U, Mueller-Premru M, Papst L. Evaluation of the routine antimicrobial susceptibility testing results of clinically significant anaerobic bacteria in a Slovenian tertiary-care hospital in 2015. Anaerobe. 2017;47:64-9.10.1016/j.anaerobe.2017.04.00728433670
Search in Google Scholar Back to article

The clinically important anaerobic, human pathogenic Bacteroides species and their antibiotic resistance levels in Central and Southeast Europe

Abstract

Paradigm

My account