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Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies Cover

Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies

Materials Science-Poland
Volume 43 (2025): Issue 2 (June 2025)
By: Huanli Hu and  Xueyang Zheng  
Open Access
|Jun 2025

Figures & Tables

Figure 1

SEM images of nicaraven-loaded and nicaraven-free gelatin nanofibers.
SEM images of nicaraven-loaded and nicaraven-free gelatin nanofibers.

Figure 2

SEM images of NICGELCOL and GELCOL sponges.
SEM images of NICGELCOL and GELCOL sponges.

Figure 3

MTT assay with L929 cells cultured on NICGELCOL and GELCOL scaffolds during 5 days of culture on the scaffolds.
MTT assay with L929 cells cultured on NICGELCOL and GELCOL scaffolds during 5 days of culture on the scaffolds.

Figure 4

Swelling properties of NICGELCOL and GELCOL sponges incubated in PBS for 24 h.
Swelling properties of NICGELCOL and GELCOL sponges incubated in PBS for 24 h.

Figure 5

MTT assay with L929 cells cultured with 1% H2O2 and NICGELCOL and GELCOL sponges. * shows p-value <0.05.
MTT assay with L929 cells cultured with 1% H2O2 and NICGELCOL and GELCOL sponges. * shows p-value <0.05.

Figure 6

Radical scavenging activity of NICGELCOL and GELCOL sponges compared with ascorbic acid as the control group.
Radical scavenging activity of NICGELCOL and GELCOL sponges compared with ascorbic acid as the control group.

Figure 7

In vitro wound closure with L929 cells cultured with NICGELCOL and GELCOL sponges on days 1 and 2. * shows p-value <0.05.
In vitro wound closure with L929 cells cultured with NICGELCOL and GELCOL sponges on days 1 and 2. * shows p-value <0.05.

Figure 8

In vivo wound closure assay with NICGELCOL and GELCOL sponges in diabetic rats on days 7 and 14 after wounding. * shows p-value <0.05.
In vivo wound closure assay with NICGELCOL and GELCOL sponges in diabetic rats on days 7 and 14 after wounding. * shows p-value <0.05.

Figure 9

Histopathological studies in diabetic wounds treated with NICGELCOL and GELCOL sponges and histomorphometric analysis. * shows p-value <0.05.
Histopathological studies in diabetic wounds treated with NICGELCOL and GELCOL sponges and histomorphometric analysis. * shows p-value <0.05.

Figure 10

ELISA results demonstrating the tissue concentrations of IL6 and TNF-α in wound tissues treated with NICGELCOL and GELCOL sponges. * shows p-value <0.05.
ELISA results demonstrating the tissue concentrations of IL6 and TNF-α in wound tissues treated with NICGELCOL and GELCOL sponges. * shows p-value <0.05.
DOI: https://doi.org/10.2478/msp-2025-0006 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
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Language: English
Page range: 40 - 51
Submitted on: Apr 18, 2024
Accepted on: Feb 10, 2025
Published on: Jun 30, 2025
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Nanocomposite,
Diabetic wound,
Nicaraven,
Drug delivery
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2025 Huanli Hu, Xueyang Zheng, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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