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Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies Cover

Freeze-dried collagen nanocomposite sponges loaded with nicaraven-incorporated gelatin nanofibers for excisional diabetic wound healing: In vitro and in vivo studies

Materials Science-Poland
Volume 43 (2025): Issue 2 (June 2025)
By: Huanli Hu and  Xueyang Zheng  
Open Access
|Jun 2025

Figures & Tables

Figure 1

SEM images of nicaraven-loaded and nicaraven-free gelatin nanofibers.

Figure 2

SEM images of NICGELCOL and GELCOL sponges.

Figure 3

MTT assay with L929 cells cultured on NICGELCOL and GELCOL scaffolds during 5 days of culture on the scaffolds.

Figure 4

Swelling properties of NICGELCOL and GELCOL sponges incubated in PBS for 24 h.

Figure 5

MTT assay with L929 cells cultured with 1% H2O2 and NICGELCOL and GELCOL sponges. * shows p-value <0.05.

Figure 6

Radical scavenging activity of NICGELCOL and GELCOL sponges compared with ascorbic acid as the control group.

Figure 7

In vitro wound closure with L929 cells cultured with NICGELCOL and GELCOL sponges on days 1 and 2. * shows p-value <0.05.

Figure 8

In vivo wound closure assay with NICGELCOL and GELCOL sponges in diabetic rats on days 7 and 14 after wounding. * shows p-value <0.05.

Figure 9

Histopathological studies in diabetic wounds treated with NICGELCOL and GELCOL sponges and histomorphometric analysis. * shows p-value <0.05.

Figure 10

ELISA results demonstrating the tissue concentrations of IL6 and TNF-α in wound tissues treated with NICGELCOL and GELCOL sponges. * shows p-value <0.05.
DOI: https://doi.org/10.2478/msp-2025-0006 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
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Language: English
Page range: 40 - 51
Submitted on: Apr 18, 2024
|
Accepted on: Feb 10, 2025
|
Published on: Jun 30, 2025
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Nanocomposite,
Diabetic wound,
Nicaraven,
Drug delivery
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2025 Huanli Hu, Xueyang Zheng, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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