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Evaluation of regular treadmill exercise plan combined with electrospun scaffolds loaded with green tea extract and bone marrow-derived mesenchymal stem cells for spinal cord injury repair in a rat model Cover

Evaluation of regular treadmill exercise plan combined with electrospun scaffolds loaded with green tea extract and bone marrow-derived mesenchymal stem cells for spinal cord injury repair in a rat model

Materials Science-Poland
Volume 42 (2024): Issue 4 (December 2024)
By: Jianjun Wang,  Tao Zhang,  Yingqi Jiang,  Wei Han,  Shimeng Huang,  Jihong Zhao and  Xiru Du  
Open Access
|Dec 2024

Figures & Tables

Figure 1

MTT assay with PC-12 cultured on GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.
MTT assay with PC-12 cultured on GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.

Figure 2

MTT assay under 1% H2O2 with PC-12 cells cultured with GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.
MTT assay under 1% H2O2 with PC-12 cells cultured with GTEPCLGEL and PCLGEL scaffolds. * shows p-value <0.05.

Figure 3

DPPH assay with GTEPCLGEL and PCLGEL scaffolds compared with ascorbic acid as the control group. * shows p-value <0.05.
DPPH assay with GTEPCLGEL and PCLGEL scaffolds compared with ascorbic acid as the control group. * shows p-value <0.05.

Figure 4

Stress–strain curve for GTEPCLGEL and PCLGEL scaffolds.
Stress–strain curve for GTEPCLGEL and PCLGEL scaffolds.

Figure 5

Hemolysis activity of GTEPCLGEL and PCLGEL scaffolds compared with normal saline and triton x-100 as the negative and positive control groups, respectively. * shows p-value <0.05.
Hemolysis activity of GTEPCLGEL and PCLGEL scaffolds compared with normal saline and triton x-100 as the negative and positive control groups, respectively. * shows p-value <0.05.

Figure 6

Anti-inflammatory assay with GTEPCLGEL and PCLGEL scaffolds compared with the macrophage cells cultured on the tissue culture plate as the control group. * shows p-value <0.05.
Anti-inflammatory assay with GTEPCLGEL and PCLGEL scaffolds compared with the macrophage cells cultured on the tissue culture plate as the control group. * shows p-value <0.05.

Figure 7

SEM images and size distribution of (a) GTEPCLGEL and (b) PCLGEL scaffolds.
SEM images and size distribution of (a) GTEPCLGEL and (b) PCLGEL scaffolds.

Figure 8

H&E staining images of spinal cord tissues in animals treated with (a) GTEPCLGELBM-MSCsPH, (b) GTEPCLGELBM-MSCs, (c) PCLGELPH, (d) PCLGEL, and (e) negative control. Arrows indicate vacuolation, asterisks denote edema, and axonal disintegration is indicated by arrowheads.
H&E staining images of spinal cord tissues in animals treated with (a) GTEPCLGELBM-MSCsPH, (b) GTEPCLGELBM-MSCs, (c) PCLGELPH, (d) PCLGEL, and (e) negative control. Arrows indicate vacuolation, asterisks denote edema, and axonal disintegration is indicated by arrowheads.

Figure 9

BBB scores in rats treated with different strategies on weeks 2, 4, and 8 after surgery. * shows p-value <0.05.
BBB scores in rats treated with different strategies on weeks 2, 4, and 8 after surgery. * shows p-value <0.05.

Figure 10

Hotplate latency test results in animals treated with different strategies, * shows p-value <0.05.
Hotplate latency test results in animals treated with different strategies, * shows p-value <0.05.

Figure 11

Tissue concentrations of BDNF, NGF, TNF-α, and IL-6 in spinal cord tissues treated with different strategies. * shows p-value <0.05.
Tissue concentrations of BDNF, NGF, TNF-α, and IL-6 in spinal cord tissues treated with different strategies. * shows p-value <0.05.
DOI: https://doi.org/10.2478/msp-2024-0038 | Journal eISSN: 2083-134X | Journal ISSN: 2083-1331
Journal RSS Feed
Language: English
Page range: 79 - 91
Submitted on: Apr 29, 2024
|
Accepted on: Oct 22, 2024
|
Published on: Dec 31, 2024
Published by: Wroclaw University of Science and Technology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Spinal cord injury,
Sport medicine,
Drug delivery
Related subjects:
Materials sciences,
Materials sciences, other,
Nanomaterials,
Functional and smart materials,
Materials characterization and properties

© 2024 Jianjun Wang, Tao Zhang, Yingqi Jiang, Wei Han, Shimeng Huang, Jihong Zhao, Xiru Du, published by Wroclaw University of Science and Technology
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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