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Pet Owners’ Knowledge, Attitudes, and Practices Regarding Antimicrobial Use and Antimicrobial Resistance in Companion Animals in North Macedonia Cover

Pet Owners’ Knowledge, Attitudes, and Practices Regarding Antimicrobial Use and Antimicrobial Resistance in Companion Animals in North Macedonia

Open Access
|Oct 2026

References

  1. World Health Organization (2025). Global antibiotic resistance surveillance report 2025: WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS). Geneva: World Health Organization[A1.1] https://doi.org/10.2471/B09585
  2. Mader, R., Demay, C., Jouvin-Marche, E., Ploy, M.C., Barraud, O., Bernard, S., et al. (2022). Defining the scope of the European Antimicrobial Resistance Surveillance network in veterinar y medicine (EARS-Vet): a bottom-up and One Health approach. J Antimicrob Chemother. 77(3): 816-826.
  3. European Medicines Agency (2025). European sales and use of antimicrobials for veterinary medicine (ESUAvet): annual surveillance report for 2023. Amsterdam: European Medicines Agency[A2.1]
  4. Zhao, R., Hao, J., Yang, J., Tong, C., Xie, L., Xiao, D., Zeng, Z., Xiong, W. (2022). The co-occurrence of antibiotic resistance genes between dogs and their owners in families. Imeta. 1(2): e21. https://doi.org/10.1002/imt2.21 PMid:38868570
  5. Kovačević, Z., Gračner, G.G., Tomanić, D., Vlahović, K., Šarić, L., Novaković, D., et al. (2025). Compounding and use of human medicinal products in small animal practice: what are the perspectives of veterinarians?-A pilot study. Vet Sci. 12(9): 914. https://doi.org/10.3390/vetsci12090914 PMid:41012840 PMCid:PMC12474484
  6. Marco-Fuertes, A., Marin, C., Lorenzo-Rebenaque, L., Vega, S., Montoro-Dasi, L. (2022). Antimicrobial resistance in companion animals: a new challenge for the One Health approach in the European Union. Vet Sci. 9(5): 208. https://doi.org/10.3390/vetsci9050208 PMid:35622736 PMCid:PMC9146952
  7. European Medicines Agency (2019). Categorisation of antibiotics in the European Union. Amsterdam: European Medicines Agency[A3.1]
  8. Caneschi, A., Bardhi, A., Barbarossa, A., Zaghini, A. (2023). The use of antibiotics and antimicrobial resistance in veterinar y medicine, a complex phenomenon: a nar rative review. Antibiotics (Basel). 12(3): 487. https://doi.org/10.3390/antibiotics12030487 PMid:36978354 PMCid:PMC10044628
  9. Hardefeldt, L.Y., Holloway, S., Trott, D.J., Shipstone, M., Barrs, V.R., Malik, R., et al. (2017). Antimicrobial prescribing in dogs and cats in Australia: results of the Australasian infectious disease advisory panel survey. J Vet Intern Med. 31(4): 1100-1107. https://doi.org/10.1111/jvim.14733 PMid:28514013 PMCid:PMC5508328
  10. Shikoska, I., Cvetkovikj, A., Nikolovski, M., Cvetkovikj, I. (2024). Understanding antimicrobial prescription practices: Insights from small animal veterinarians in North Macedonia. Mac Vet Rev. 47(2): 103-114. https://doi.org/10.2478/macvetrev-2024-0020
  11. Monteiro, H.I.G., Silva, V., de Sousa, T., Calouro, R., Saraiva, S., Igrejas, G., Poeta, P. (2025). Antimicrobial resistance in European companion animals practice: a One Health approach. Animals. 15(12): 1708. https://doi.org/10.3390/ani15121708 PMid:40564260 PMCid:PMC12189186
  12. Grönthal, T., Österblad, M., Eklund, M., Jalava, J., Nykäsenoja, S., Pekkanen, K., et al. (2018). Sharing more than friendship - transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015. Euro Surveill. 23(27): 1700497. https://doi.org/10.2807/1560-7917.ES.2018.23.27.1700497 PMid:29991384 PMCid:PMC6152158
  13. Dickson, A., Smith, M., Smith, F., Park, J., King, C., Currie, K., et al. (2019). Understanding the relationship between pet owners and their companion animals as a key context for antimicrobial resistance-related behaviours: an interpretative phenomenological analysis. Health Psychol Behav Med. 7(1): 45-61. https://doi.org/10.1080/21642850.2019.1577738 PMid:34040838 PMCid:PMC8114347
  14. Hopman, N.E.M., Hulscher, M.E.J.L., Graveland, H., Speksnijder, D.C., Wagenaar, J.A., Broens, E.M. (2018). Factors influencing antimicrobial prescribing by Dutch companion animal veterinarians: A qualitative study. Prev Vet Med. 158, 106-113. https://doi.org/10.1016/j.prevetmed.2018.07.013 PMid:30220383
  15. Smith, M., King, C., Davis, M., Dickson, A., Park, J., Smith, F., et al. (2018). Pet owner and vet interactions: Exploring the drivers of AMR. Antimicrob Resist Infect Control. 7, 46. https://doi.org/10.1186/s13756-018-0341-1 PMid:29619213 PMCid:PMC5879597
  16. Aithal, S., Guo, H., Teo, B.H., Chua, T., Hildon, Z.J.-L., Chow, A. (2025). Pet owners’ knowledge of antibiotic use and antimicrobial resistance and their antibiotic practices: comparison between contexts of self and pet. Antibiotics (Basel). 14(2): 158. https://doi.org/10.3390/antibiotics14020158 PMid:40001402 PMCid:PMC11851957
  17. Scarborough, R.O., Sri, A.E., Browning, G.F., Hardefeldt, L.Y., Bailey, K.E. (2023). ‘Brave enough’: a qualitative study of veterinary decisions to withhold or delay antimicrobial treatment in pets. Antibiotics (Basel). 12(3): 540. https://doi.org/10.3390/antibiotics12030540 PMid:36978407 PMCid:PMC10044613
  18. Dias, M.C., Alpizar-Jara, R., Lavrador, C., Marques, C., Broens, E.M., Duarte, E.L. (2024). Companion animal owners’ knowledge, attitudes and perceptions regarding antibiotic use in Portugal. Antibiotics. 13(6): 533. https://doi.org/10.3390/antibiotics13060533 PMid:38927199 PMCid:PMC11201214
  19. Frey, E., Kedrowicz, A., Hedgpeth, M.W. (2022). Exploring companion animal caretakers’ attitudes, perceptions and behavioural drivers of antimicrobial use within the social context of veterinary care. J Small Anim Pract. 63(12): 873-881. https://doi.org/10.1111/jsap.13549 PMid:36084956 PMCid:PMC10086989
  20. Arnecke, A.L., Schwarz, S., Lübke-Becker, A., Jensen, K.C., Bahramsoltani, M. (2024). A Survey on companion animal owners’ perception of veterinarians’ communication about zoonoses and antimicrobial resistance in Germany. Animals (Basel). 14(22): 3346. https://doi.org/10.3390/ani14223346 PMid:39595398 PMCid:PMC11590884
  21. Scarborough, R., Hardefeldt, L., Browning, G., Bailey, K. (2021). Pet owners and antibiotics: knowledge, opinions, expectations, and communication preferences. Antibiotics (Basel). 10(11): 1326. https://doi.org/10.3390/antibiotics10111326 PMid:34827264 PMCid:PMC8615269
  22. Redding, L.E., Cole, S.D. (2019). Pet owners’ knowledge of and attitudes toward the judicious use of antimicrobials for companion animals. J Am Vet Med Assoc. 254(5): 626-635. https://doi.org/10.2460/javma.254.5.626 PMid:30779623
  23. Candellone, A., Badino, P., Girolami, F., Ala, U., Mina, F., Odore, R. (2023). Dog owners’ attitude toward veterinary antibiotic use and antibiotic resistance with a focus on canine diar rhea management. Animals (Basel). 13(6): 1061. https://doi.org/10.3390/ani13061061 PMid:36978602 PMCid:PMC10044205
  24. Stallwood, J., Shirlow, A., Hibbert, A. (2020). A UK-based survey of cat owners’ perceptions and experiences of antibiotic usage. J Feline Med Surg. 22(2): 69-76. https://doi.org/10.1177/1098612X19826353 PMid:30720397 PMCid:PMC10814557
  25. Wang, X., Lin, L., Xuan, Z., Li, L., Zhou, X. (2018). Keeping antibiotics at home promotes self-medication with antibiotics among Chinese university students. Int J Environ Res Public Health. 15(4): 687. https://doi.org/10.3390/ijerph15040687 PMid:29621165 PMCid:PMC5923729
  26. Allerton, F., Prior, C., Bağcıgil, A.F., Broens, E.M., Callens, B., Damborg, P., et al. (2021). Overview and evaluation of existing guidelines for rational antimicrobial use in small-animal veterinary practice in Europe. Antibiotics (Basel). 10(4): 409. https://doi.org/10.3390/antibiotics10040409 PMid:33918617 PMCid:PMC8069046
  27. Galarce, N., Dumont-Viollaz, A., Longa, J., del Río, L.C., Núñez, A., Guzmán-Marín, B., Thomson, P. (2025). Perceptions of antimicrobial use and resistance among pet owners in Chile: A cross-sectional One Health survey. Vet World. 18(8): 2450-2459. https://doi.org/10.14202/vetworld.2025.2450-2459 PMid:41064845 PMCid:PMC12501537
  28. Wright, E., Jessen, L.R., Tompson, A., Rutland, C., Singleton, D., Battersby, I., et al. (2024). Influencing attitudes towards antimicrobial use and resistance in companion animals-the impact on pet owners of a short animation in a randomized controlled trial. JAC Antimicrob Resist. 6 (3): dlae065. https://doi.org/10.1093/jacamr/dlae065 PMid:38716404 PMCid:PMC11073752
  29. Tomanic, D., Stojanovic, D., Belić, B., Davidov, I., Novakov, N., Radinovic, M., et al. (2021). Off label use of human approved drugs in treatment of dogs in the Republic of Serbia. Pol J Vet Sci. 24(3): 399-407. https://doi.org/10.24425/pjvs.2021.138731 PMid:34730304
  30. Shikoska, I., Duvnjak, S., Koritnik, T., Chapkunovska, B., Vlahov, J., Ratkova Manovska, M., Cvetkovikj, A., Cvetkovikj, I. (2025). Extended-spectr um β-Lactamase-/AmpC-Producing Escherichia coli and associated risk factors in shelter dogs: a baseline study in North Macedonia. Microbiol Res. 16(9): 206. https://doi.org/10.3390/microbiolres16090206
  31. Shikoska, I., Hristovska, Z.P., Matevski, I., Pavlova, M.J., Manovska, M.R., Cvetkovikj, A., Cvetkovikj, I. (2025). Phenotypic and molecular characterization of antimicrobial resistance in canine Staphylococci from North Macedonia. Mac Vet Rev. 48 (2): 159-172. https://doi.org/10.2478/macvetrev-2025-0022
  32. Stein, M.R., Weese, J.S., Stull, J.W., McClure, J.T., Evason, M. (2022). Knowledge, attitudes and influencers of cat owners in North America around antimicrobials and antimicrobial stewardship. J Feline Med Surg. 24(6): e90-e97. https://doi.org/10.1177/1098612X221090456
  33. Chadborn, T., Williams, S., Jorgensen, T., Price, C., Buckel, A., Altieri, E. (2023). An approach for embedding behavioural science in antimicrobial resistance One Health research. J Infect Public Health. 16 (Suppl 1): 134-140. https://doi.org/10.1016/j.jiph.2023.11.001 PMid:37973498
Language: English
Submitted on: Mar 12, 2026
Accepted on: Jun 23, 2026
Published on: Oct 6, 2026
Published by: Ss. Cyril and Methodius University in Skopje
In partnership with: Paradigm Publishing Services

© 2026 Ivana Shikoska, Jane Vlahov, Boris Dimitrievski, Bojana Chapkunovska, Ljubica Rashikj, Mirko Prodanov, Martin Nikolovski, Elena Atanaskova Petrov, Aleksandar Cvetkovikj, Iskra Cvetkovikj, published by Ss. Cyril and Methodius University in Skopje
This work is licensed under the Creative Commons Attribution 4.0 License.