Mammary Adenocarcinoma with Widespread Metastasis in a Lion (Panthera Leo)

Gjurovski, Ivica; Dovenska, Monika; Kunovska, Slavica Kostadinova; Milosevski, Jordanco; Trajkov, Vesna Levajkovic; Ristoski, Trpe

doi:10.2478/macvetrev-2019-0019

Abstract

A 15 year old female African lion (Panthera leo) was necropsied after its sudden death. The necropsy showed a mammary gland lesion measuring 10 cm in diameter and numerous white nodules with variable size in the liver, spleen, uterus, lungs and the heart. The histopathological examination showed that the neoplastic formation in the mammary region was a simple tubular carcinoma with metastases on the other organs. Upon immunohistochemical examination, the neoplastic cells expressed cytokeratins while the stroma of the tumour expressed vimentin. The proliferation index Ki-67 was moderate. Based on the macroscopic, histopathological and immunohistochemical findings, the neoplasia was diagnosed as a simple tubular mammary carcinoma.

References

1. Vail, D. M., Mac Ewen, E.G. (2000). Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest. 18(8): 781-792. https://doi.org/10.3109/07357900009012210 PMid:1110744810.3109/0735790000901221011107448
Search in Google Scholar Back to article
2. Misdorp, W. (2002). Tumors of the mammary gland. In: Meuten DJ. (Ed.), Tumors in domestic animals (pp. 575-606). 4th ed. Ames, USA: Iowa State Press. https://doi.org/10.1002/9780470376928.ch1210.1002/9780470376928.ch12
Open DOI Search in Google Scholar Back to article
3. Schmidt, R. E., Langham, R. F. (1967). A survey of feline neoplasms. J Am Vet Med Assoc. 151, 1325-1328.
Search in Google Scholar Back to article
4. Hayden, D. W., Nielsen, S. W. (1971). Feline mammary tumors. J Small Anim Pract. 12, 687-698. https://doi.org/10.1111/j.1748-5827.1971.tb06197.x PMid:433537710.1111/j.1748-5827.1971.tb06197.xPMid:4335377
Open DOI Search in Google Scholar Back to article
5. Weijer, K., Head, K. W., Misdorp, W., et al. (1972). Feline malignant mammary tumors. I. Morphology and biology: some comparisons with human and canine mammary carcinomas. J Natl Cancer Inst. 49, 1697-1704. https://doi.org/10.1093/jnci/49.6.1697 PMid:434602010.1093/jnci/49.6.1697PMid:4346020
Open DOI Search in Google Scholar Back to article
6. Ryan, A. S., Linden, E. C., Edward, C. R., Kelly H., Darin C., Michael, M. G. (2016). Clinicopathologic features of mammary masses in captive lions (Panthera Leo). Journal of Zoo and Wildlife Medicine 47(1): 127-131. https://doi.org/10.1638/2015-0087.1 PMid:2701027310.1638/2015-0087.1PMid:27010273
Open DOI Search in Google Scholar Back to article
7. Gilette, D. M., Acland, H. M., Klein, L. (1991). Ductular mammary carcinoma in a lioness. J Am Vet Med Assoc. 173, 1099-1102.
Search in Google Scholar Back to article
8. Misdorp, W., Else, R. W., Hellmen, E., et al. (1999). Histological classification of mammary tumors of the dog and the cat. 2nd ed. Washington, USA: Armed Forces Institute of Pathology 3-29.
Search in Google Scholar Back to article
9. Misdorp, W., Cotchin, E., Hampe, J. F., et al. (1971). Canine malignant mammary tumors: I. Sarcomas. Vet Pathol. 8(2): 99-117. https://doi.org/10.1177/030098587100800202 PMid:436743210.1177/030098587100800202PMid:4367432
Open DOI Search in Google Scholar Back to article
10. Fox, D. B., Cook, J. L., Kreeger, J. M., Beissenherz, M., Henry, C. J. (2002). Canine synovial sarcoma: a retrospective assessment of described prognostic criteria in 16 cases (1994-1999). J Am Anim Hosp Assoc. 38, 347-355. https://doi.org/10.5326/0380347 PMid:1211868810.5326/038034712118688
Search in Google Scholar Back to article
11. Niveditha, S. R, Bajaj, P. (2003). Vimentin expression in breast carcinomas. Indian J Pathol Microbiol. 46, 579-584.
Search in Google Scholar Back to article
12. Hemalatha, A., Suresh, T. N., Harendra, K. M. L. (2013). Expression of vimentin in breast carcinoma, its correlation with Ki-67 and other histopathological parameters. Indian J Cancer. 50, 189-194. https://doi.org/10.4103/0019-509X.118724 PMid:2406145710.4103/0019-509X.118724PMid:24061457
Open DOI Search in Google Scholar Back to article
13. Lian T. L., Guan, J., Qian, C., Jun, N. Z. (2015). Ki-67 is a promising molecular target in the diagnosis of cancer. Mol Med Rep.11, 1566-1572. https://doi.org/10.3892/mmr.2014.2914 PMid:2538467610.3892/mmr.2014.2914PMid:25384676
Open DOI Search in Google Scholar Back to article
14. Cagnini, D. Q., Salgado, B. S., Linardi, J. L., Grandi, F., Rocha, R. M., Rocha, N. S., Teixeira, C. R., Del Piero, F., Sequeira, J. L. (2012). Ocular melanoma and mammary mucinous carcinoma in an African lion. BMC Veterinary Research 8, 176. https://doi.org/10.1186/1746-6148-8-176 PMid:23009723 PMCid:PMC351731910.1186/1746-6148-8-176351731923009723
Search in Google Scholar Back to article
15. Sonmez, G., Aytug, N., Akkoc, A., Cihan, H., Alasonyalilar, A. (2018). Intestinal adenocarcinoma with diffuse peritoneal carcinomatosis in a lion (Panthera leo). Eur J Wildl Res. 54, 385-389. https://doi.org/10.1007/s10344-007-0151-x10.1007/s10344-007-0151-x
Open DOI Search in Google Scholar Back to article
16. Riccardi, E., Greco, V., Verganti, S., Finazzi, M. (2007). Immunohistochemical diagnosis of canine ovarian epithelial and granulosa cell tumors. J Vet Diagn Invest. 19, 431-435. https://doi.org/10.1177/104063870701900418 PMid:1760935810.1177/104063870701900418PMid:17609358
Open DOI Search in Google Scholar Back to article
17. Toniti, P., Sirivisoot, S., Jandee, P., Srimontri, P., Puchadapirom, P., Doungchawee, G., Kasorndorkbua, C. (2010). AE1/AE3, Vimentin and p63 Immunolocalization in canine mammary gland tumours: roles in differentiation between luminal epithelial and myoepithelial lineages. Asian Pac. J. Cancer Prev. 11, 227-230.
Search in Google Scholar Back to article
18. Aydogan, A., Metin, N. (2013). Detection of cell origin by immunohistochemistry in canine mammary tumours. Revue Méd. Vét. 164, 7, 395-399.
Search in Google Scholar Back to article
19. Caliari, D., Zappulli, V., Rasotto, R., Cardazzo, B., Frassineti, F., Goldschmidt, M. H., Castagnaro, M. (2014). Triple-negative vimentin-positive heterogeneous feline mammary carcinomas as a potential comparative model for breast cancer. BMC Vet Res. 10, 185. https://doi.org/10.1186/s12917-014-0185-8 PMid:25249140 PMCid:PMC418058410.1186/s12917-014-0185-8418058425249140
Search in Google Scholar Back to article
20. Karabolovski, N., Gudan Kurilj, A., Severin, K., Hohsteter, M., Sostaric Zuckermann, I.-C., Medveny, L., Artuković, B., Grabarevic, Z. (2016). Immunohistochemical study of epithelialmesenchymal transition in feline mammary tumours. Journal of Comparative Pathology 154(1): 114. https://doi.org/10.1016/j.jcpa.2015.10.14510.1016/j.jcpa.2015.10.145
Open DOI Search in Google Scholar Back to article

Mammary Adenocarcinoma with Widespread Metastasis in a Lion (Panthera Leo)

Abstract

Paradigm

My account