Acute Phase Proteins – As Indicators of Claw Diseases in Dairy Cattle

Ilievska, Ksenija; Atanasov, Branko; Dovenski, Toni; Smolac, Ozren; Stojanov, Boris; Trojachanec, Plamen

doi:10.2478/macvetrev-2019-0011

Abstract

The serum concentration of certain acute phase proteins significantly increases during various pathological conditions in cattle. The aim of this study was to determine the influence of claw disorders etiology on the concentrations of two major acute phase proteins in dairy cattle: haptoglobin (Hp) and serum amyloid protein A (SAA). Fifty dairy cows with claw pathology were included. Fourteen clinically healthy heifers served as controls. The animals were subdivided in 5 groups according to the pathological findings on their claws: 1. Heel horn erosion (HE), 2. Acute laminitis (AL), 3. Sole ulcer (SU), 4. Digital dermatitis (DD) and 5. White line separation (WLS). Hp and SAA concentrations were measured in serum samples using commercial ELISA kits. Higher concentrations of both Hp and SAA were found in the AL and SU groups (p<0.01) compared to the HE, DD and WLS and control groups. Dairy cows in the DD group had higher (p<0.05) Hp and SAA concentrations than the HE and WLS groups and the controls. The serum values between the HE, WLS and the control group did not differ significantly. The presented results indicate that the claw diseases are associated with a systemic acute phase response. Hp and SAA could be used as valuable biomarkers for early detection of claw diseases in dairy cows.

References

1. Whay, H.R., Main, D.C.J., Green, L.E., Webster, A.J.F. (2002). Farmer perception of lameness prevalence. Proc. 12th International Symposium on Lameness in Ruminants, (pp. 355 – 358), Orlando, Florida
Search in Google Scholar Back to article
2. Radeski, M., Janevski, A., Ilieski, V. (2015). Screening of selected indicators of dairy cattle welfare in Macedonia. Mac Vet Rev. 38 (1): 43-51. https://doi.org/10.14432/j.macvetrev.2014.11.03110.14432/j.macvetrev.2014.11.031
Search in Google Scholar Back to article
3. Garbarino, E. (2004). Efect of lameness on ovarian activity in post-partum holstein cows. Thesis, University of Florida, Gainesville, Florida
Search in Google Scholar Back to article
4. Weaver, D.A., Jean, S.G., Steiner, A. (2005). Lameness. In: (2nd. ed.), Bovine surgery and lameness (pp. 198-258). Blackwell Publishing https://doi.org/10.1002/9780470751138.ch710.1002/9780470751138.ch7
Open DOI Search in Google Scholar Back to article
5. Green, L.E., Hedges, V.J., Schukken, Y.H., Blowey, R.W., Packington, A.J. (2002). The impact of clinical lameness on the milk yield of dairy cows. J Dairy Sci. 58, 2250-2256. https://doi.org/10.3168/jds.S0022-0302(02)74304-X10.3168/jds.S0022-0302(02)74304-X
Open DOI Search in Google Scholar Back to article
6. Murray, R.D., Downham D.Y., Clarkson M. J., Faull, W.B., Hughes, J.W., et al. (1996). Epidemiology of lameness in dairy cattle: Description and analysis of foot lesions. Vet Rec. 138, 586–591. https://doi.org/10.1136/vr.138.24.586 PMid:879998510.1136/vr.138.24.586PMid:8799985
Open DOI Search in Google Scholar Back to article
7. Greenough, P. R., Maccallum, F. J., Weaver, A.D. (1981). Lameness in cattle. (2nd ed.), Bristol: John Wright & Sons Ltd. PMCid:PMC327455
Search in Google Scholar Back to article
8. Shearer, J.K., Bray, D.R., Uphrey, J.E., Elliot, J.B. (1996). Factors influencing the incidence of lameness in dairy cattle. Proceedings of the 33rd Annual Florida Dairy Conference. (pp. 40-51), Gainesville, Florida, USA
Search in Google Scholar Back to article
9. Bergsten, C., Hancock, D.D., Gay, J.M., Gay, C.C., Fox, L.K. (1998). Claw diseases: the most common cause of dairy lameness diagnosis, frequencies and risk groups in a University herd. Proceedings of the 31st Annual Convention of the American Association of Bovine Practitioners, 24-26 September, (pp. 188-194), Spokane, Washington, USA10.21423/aabppro19985725
Search in Google Scholar Back to article
10. Dinarello, C.A. (1984). Interleukin-1 and the pathogenesis of the acute-phase response. N Engl J Med. 311, 1413-1418. https://doi.org/10.1056/NEJM198411293112205 PMid:620848510.1056/NEJM198411293112205
Search in Google Scholar Back to article
11. Bauman, H., Gauldie, J. (1994). Thе acute phase response. Immunol Today. 15, 74-80. https://doi.org/10.1016/0167-5699(94)90137-610.1016/0167-5699(94)90137-6
Open DOI Search in Google Scholar Back to article
12. Standyk, A.W., Gauldie, J. (1991). The acute phase protein response during parasitic infection. Parasitol Today. 7, 7-12. https://doi.org/10.1016/0169-4758(91)90021-F10.1016/0169-4758(91)90021-
Open DOI Search in Google Scholar Back to article
13. Eckersall, P.D., Conner, J. G. (1988). Bovine and canine acute phase proteins. Vet Res Commun. 12, 169-178. https://doi.org/10.1007/BF00362798 PMid:246099110.1007/BF00362798PMid:2460991
Open DOI Search in Google Scholar Back to article
14. Murata, H., Shimada, N., Yoshioka, M. (2004). Current research on acute phase proteins in veterinary diagnosis: an overview. Vet J. 168, 24-40. https://doi.org/10.1016/S1090-0233(03)00119-910.1016/S1090-0233(03)00119-9
Open DOI Search in Google Scholar Back to article
15. Gruys, E., Van Edern, M., Alsemgeest, S.P.M., Kalsbeek, H. C., Wensing, T. (1993). Acute phase proteins values in blood of cattle as indicator of animals with pathological processes. Arhiv fur Lebensmittlehygene 44, 107-111.
Search in Google Scholar Back to article
16. Kushner, I. (1982). The phenomenon of acute phase response. Ann NY Acad Sci. 389, 39-48. https://doi.org/10.1111/j.1749-6632.1982.tb22124.x PMid:704658510.1111/j.1749-6632.1982.tb22124.xPMid:7046585
Open DOI Search in Google Scholar Back to article
17. Cho, J.G. (2002). Acute phase proteins in dairy cows with mastitis. Korean J Vet Sci. 25(4): 377-384.
Search in Google Scholar Back to article
18. Hirvonen, J., Pyöräla, S. (1998). Acute-phase response in dairy cows with surgically-treated abdominal disorders. Vet J. 155, 53–61. https://doi.org/10.1016/S1090-0233(98)80036-110.1016/S1090-0233(98)80036-1
Open DOI Search in Google Scholar Back to article
19. Horadagoda, N.U., Knox, K.M.G., Gibbs, H.A., Reid, S.W.J, Horadagoda, A.S.E., et al. (1999). Acute phase proteins in cattle: discrimination between acute and chronic inflammation. Vet Rec. 144(16): 437-441. https://doi.org/10.1136/vr.144.16.437 PMid:1034337510.1136/vr.144.16.437PMid:10343375
Open DOI Search in Google Scholar Back to article
20. Thotova, C., Nagy, O., Seidel, H., Paulikova, I., Kovac, G. (2011). The influence of claw diseases on the concentrations of some acute phase proteins and other variables of the protein profile in heifers. Acta Vet. 61 (2-3): 141-150. https://doi.org/10.2298/AVB1103141T10.2298/AVB1103141
Open DOI Search in Google Scholar Back to article
21. Uchida, E., Katoh, N., Takahashi, K. (1993). Appearance of haptoglobin in serum from cows at parturition. J Vet Med Sci. 55, 893-894. https://doi.org/10.1292/jvms.55.893 PMid:828655610.1292/jvms.55.893PMid:8286556
Open DOI Search in Google Scholar Back to article
22. Hirvonen, J. (2000). Hirvonen’s thesis on acute phase response in dairy cattle.[Internet]. Academic dissertation, Faculty of veterinary medicine, University of Helsinki. https://helda.helsinki.fi/bitstream/handle/1975/55/acutepha.pdf?sequence=2&isAllowed=y
Search in Google Scholar Back to article
23. Conner, J.G., Eckersall, P. D., Wiseman, A., Aitchison, T.C., Douglas, T.A. (1998). Bovine acute phase response following turpentine injection. Res Vet Sci. 44, 82-88. https://doi.org/10.1016/0034-5288(88)90018-510.1016/0034-5288(88)90018-5
Open DOI Search in Google Scholar Back to article
24. Kujala, M. (2010). Laminitis – related lesions and lameness detection in dairy cattle in Finland. [Internet]. Academic dissertation, Faculty of veterinary medicine, University of Helsinki, Finland https://helda.helsinki.fi/bitstream/handle/10138/18997/laminiti.pdf?sequence=2
Search in Google Scholar Back to article
25. Clarkson, M. J., Faull, B., Hughes, J. W., Manson, F.J., Merritt, J.B., Murray, J.E., et al. (1996). Incidence and prevalence of lameness in dairy cattle. Vet Rec. 138(23): 563-567. https://doi.org/10.1136/vr.138.23.563 PMid:879518310.1136/vr.138.23.563PMid:8795183
Open DOI Search in Google Scholar Back to article
26. Manske, T. (2002). Claw lesions and lameness in Swedish dairy cattle: Prevalence, risk factors, effects of claw trimming and consequences for productivity. Academic dissertation, Swedish University of Agricultural Sciences, Skara, Sweeden
Search in Google Scholar Back to article
27. Dembele, I., Špinka, M., Stehulova, I., Pananma, J., Firla, P. (2006). Factors contributing to the incidence and prevalence of lameness on Czech dairy farms. Chez J of Animal Sci. 51(3): 102-109.10.17221/3916-CJAS
Search in Google Scholar Back to article
28. Јawor, P., Steiner, S., Stefaniak, T., Baumgartner, W., Rzasa, A. (2008). Determination of selected acute phase proteins during the treatment of limb diseases in dairy cow. Vet Med Czech. 53(4): 173-183.10.17221/1920-VETMED
Search in Google Scholar Back to article
29. Ettema, J.F., Østergaard, S. (2006). Economic decision making on prevention and control of clinical lameness in Danish dairy herds. Livestock Science 102, 92–106. https://doi.org/10.1016/j.livprodsci.2005.11.02110.1016/j.livprodsci.2005.11.021
Open DOI Search in Google Scholar Back to article
30. Kossaibati, M. A., Esslemont, R. J. (1997). The cost of production diseases in dairy herds in England Vet. J. 154, 41-51.10.1016/S1090-0233(05)80007-3
Search in Google Scholar Back to article
31. Smith, B.I., Kauffold, J., Sherman, L. (2010). Serum haptoglobin concentrations in dairy cattle with lameness due to claw disorders. Vet J. 186, 162-165. https://doi.org/10.1016/j.tvjl.2009.08.012 PMid:1975198310.1016/j.tvjl.2009.08.012PMid:19751983
Open DOI Search in Google Scholar Back to article
32. Nazifi S., Rezakhani, A., Koohimoghadam, M., Ansari-Lari, M., Esmailnezhad, Z. (2008). Evaluation of serum haptoglobin in clinically healthy cattle and cattle with inflammatory disease in Shiraz, a tropical area in southern Iran. Bulg J Vet Med. 11(2): 95-101.
Search in Google Scholar Back to article
33. Kennedy B.W. (1989). Introduction to linear models in animal breeding. University of Guelph. Canada
Search in Google Scholar Back to article

Acute Phase Proteins – As Indicators of Claw Diseases in Dairy Cattle

Abstract

Paradigm

My account