Effect of a herbal preparation including nanoencapsulated thymol, carvacrol and cinnamaldehyde in feed on production parameters in the farrow-to-wean sector

Ahmed S.T., Hwang J.A., Hoon J., Mun H.S., Yang C.J.: Comparison of single and blend acidifiers as alternative to antibiotics on growth performance, fecal microflora, and humoral immunity in weaned piglets. Asian-Australas J Anim Sci 2014, 27, 93, doi: 10.5713/ajas.2013.13411.
Open DOI Search in Google Scholar Back to article
Akram M., Tahir I.M., Shah S.M.A., Mahmood Z., Altaf A., Ahmad K., Naveed M., Daniyal M., Suhaila N., Hima M.: Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytother Res 2018, 32, 811–822, doi: 10.1002/ptr.6024.
Open DOI Search in Google Scholar Back to article
Alhenc-Gelas F., Drueke T.B.: Blockade of SARS-CoV-2 infection by recombinant soluble ACE2. Kidney Int 2020, 97, 1091–1093, doi: 10.1016/j.kint.2020.04.009.
Open DOI Search in Google Scholar Back to article
Astani A., Navid M.H., Schnitzler P.: Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract. Phytother Res 2014, 28, 1547–1552, doi: 10.1002/ptr.5166.
Open DOI Search in Google Scholar Back to article
Bednorz C., Oelgeschläger K., Kinnemann B., Hartmann S., Neumann K., Pieper R., Bethe A., Semmler T., Tedin K., Schierack P., Wieler L.H., Guenther S.: The broader context of antibiotic resistance: zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo. International J Med Microbiol 2013, 303, 396–403, doi: 10.1016/j.ijmm.2013.06.004.
Open DOI Search in Google Scholar Back to article
Bonetti A., Tugnoli B., Piva A., Grilli E.: Towards zero zinc oxide: Feeding strategies to manage post-weaning diarrhea in piglets. Animals 2021, 11, 642, doi: 10.3390/ani11030642.
Open DOI Search in Google Scholar Back to article
Campbell J.M., Crenshaw J.D., Polo J.: The biological stress of early weaned piglets. J Anim Sci Biotechnol 2013, 4, 19, doi: 10.1186/2049-1891-4-19.
Open DOI Search in Google Scholar Back to article
Chen C., Chen L., Mao C., Jin L., Wu S., Zheng Y., Cui Z., Li Z., Zhang Y., Zhu S.Z., Jiang H., Liu X.: Natural extracts for antibacterial applications. Small 2024, 20, 2306553, doi: 10.1002/smll.202306553.
Open DOI Search in Google Scholar Back to article
Chen H., Muhammad I., Zhang Y., Ren Y., Zhang R., Huang X., Diao L., Liu J., Li X., Sun X., Abbas G., Li G.: Antiviral activity against infectious bronchitis virus and bioactive components of Hypericum perforatum L. Front Pharmacol 2019, 10, 470683, doi: 10.3389/fphar.2019.01272.
Open DOI Search in Google Scholar Back to article
De Vrese M., Marteau P.R.: Probiotics and prebiotics: Effects on diarrhea. J Nutr 2007, 137, 803–811, doi: 10.1093/jn/137.3.803S.
Open DOI Search in Google Scholar Back to article
Gadde U., Kim W.H., Oh S.T., Lillehoj H.S.: Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: A review. Anim Health Res Rev 2017, 18, 26–45, doi: 10.1017/S1466252316000207.
Open DOI Search in Google Scholar Back to article
Gonzalez-Pastor R., Carrera-Pacheco S.E., Zúñiga-Miranda J., Rodríguez-Pólit C., Mayorga-Ramos A., Guamán L.P., Barba-Ostria C.B.: Current landscape of methods to evaluate antimicrobial activity of natural extracts. Molecules 2023, 28, 1068, doi: 10.3390/molecules28031068.
Open DOI Search in Google Scholar Back to article
Heo J.M., Opapeju F.O., Pluske J.R., Kim J.C., Hampson D.J., Nyachoti C.M.: Gastrointestinal health and function in weaned pigs: A review of feeding strategies to control post-weaning diarrhoea without using in-feed antimicrobial compounds. J Anim Physiol Anim Nutr 2013, 97, 207–237, doi: 10.1111/j.1439-0396.2012.01284.x.
Open DOI Search in Google Scholar Back to article
Huang Z., Pang D., Liao S., Zou Y., Zhou P., Li E., Weifei W.: Synergistic effects of cinnamaldehyde and cinnamic acid in cinnamon essential oil against S. pullorum. Ind Crop Prod 2021, 162, 113296, doi: 10.1016/j.indcrop.2021.113296.
Open DOI Search in Google Scholar Back to article
Karnjana K., Jewboonchu J., Niyomtham N., Tangngamsakul P., Bunluepuech K., Goodla L., Mordmuang A.: The potency of herbal extracts and its green synthesized nanoparticle formulation as antibacterial agents against Streptococcus mutans associated biofilms. Biotechnol Rep 2023, 37, e00777, doi: 10.1016/j.btre.2022.e00777.
Open DOI Search in Google Scholar Back to article
Lai W.-L., Chuang H.-S., Lee M.-H., Wei C.-L., Lin C.-F., Tsai Y.-C.: Inhibition of herpes simplex virus type 1 by thymol-related monoterpenoids. Planta Med 2012, 78, 1636–1638, doi: 10.1055/s-0032-1315208.
Open DOI Search in Google Scholar Back to article
Li Y., Cao H., Zhang S., Guo P., Zhao J., Zhang D., Zhang S.: Effects of the supplementation of essential oil mixtures on growth performance, nutrient digestibility, immune status and microbial community in weaned piglets. Animals 2023, 13, 3697, doi: 10.3390/ani13233697.
Open DOI Search in Google Scholar Back to article
Lieberman-Blum S.S., Fung H.B., Bandres J.C.: Maraviroc: a CCR5-receptor antagonist for the treatment of HIV-1 infection. Clin Ther 2008, 7, 1228–1250, doi: 10.1016/s0149-2918(08)80048-3.
Open DOI Search in Google Scholar Back to article
Luo Q., Li N., Zheng Z., Chen L., Mu S., Chen L., Liu Z., Yan J., Sun C.: Dietary cinnamaldehyde supplementation improves the growth performance, oxidative stability, immune function, and meat quality in finishing pigs. Livestock Sci 2020, 240, 104221, doi: 10.1016/j.livsci.2020.104221.
Open DOI Search in Google Scholar Back to article
Marangoni A., Foschi C., Micucci M., Nahui Palomino R.A., Toschi T.G., Camarda L., Mandrioli M., De Giorgio M., Aldini R., Corazza I., Chiarini A., Cevenini R., Budriesi R.: In vitro activity of Spirulina platensis water extract against different Candida species isolated from vulvo-vaginal candidiasis cases. PLoS One 2017, 12:e0188567, doi: 10.1371/journal.pone.0188567.
Open DOI Search in Google Scholar Back to article
Mizielińska M., Nawrotek P., Stachurska X., Ordon M., Bartkowiak A.: Packaging covered with antiviral and antibacterial coatings based on ZnO nanoparticles supplemented with geraniol and carvacrol. Int J Mol Sci 2021, 22, 1717, doi: 10.3390/ijms22041717.
Open DOI Search in Google Scholar Back to article
Rassu G., Nieddu M., Bosi P., Trevisi P., Colombo M., Priori D., Manconi P., Giunchedi P., Gavini E., Boatto G.: Encapsulation and modified-release of thymol from oral microparticles as adjuvant or substitute to current medications. Phytomedicine 2014, 21, 1627–1632, doi: 10.1016/j.phymed.2014.07.017.
Open DOI Search in Google Scholar Back to article
Sánchez C., Aznar R., Sánchez G.: The effect of carvacrol on enteric viruses. Int J Food Microbiol 2015, 192, 72–76, doi: 10.1016/j.ijfoodmicro.2014.09.028.
Open DOI Search in Google Scholar Back to article
Tan C., Wei H., Sun H., Ao J., Long G., Jiang S., Peng J.: Effects of dietary supplementation of oregano essential oil to sows on oxidative stress status, lactation feed intake of sows, and piglet performance. Biomed Res Int 2015, 2015, 525218, doi: 10.1155/2015/525218.
Open DOI Search in Google Scholar Back to article
Toker E.B., Yeşilbağ K.: In vitro antiviral activity of Thymbra spicata L. extract on bovine respiratory viruses (BCoV, BPIV-3, BRSV, BVDV and BoHV-1). J Appl Microbiol 2022, 132, 2625–2632, doi: 10.1111/jam.15418.
Open DOI Search in Google Scholar Back to article
Truchado P., Giménez-Bastida J.A., Larrosa M., Castro-Ibáñez I., Espín J.C., Tomás-Barberán F.A., García-Conesa M.T., Allende A.: Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones. J Agric Food Chem 2012, 60, 8885–8894, doi: 10.1021/jf301365a.
Open DOI Search in Google Scholar Back to article
Valdivieso-Ugarte M., Gomez-Llorente C., Plaza-Díaz J., Gil Á.: Antimicrobial, antioxidant, and immunomodulatory properties of essential oils. A Systematic Review. Nutrients 2019, 11, 2786, doi: 10.3390/nu11112786.
Open DOI Search in Google Scholar Back to article
Varel V.H.: Carvacrol and thymol reduce swine waste odor and pathogens: Stability of oils. Curr Microbiol 2002, 44, 38–43, doi: 10.1007/s00284-001-0071-z.
Open DOI Search in Google Scholar Back to article
Varel V.H., Miller D.L.: Eugenol stimulates lactate accumulation yet inhibits volatile fatty acid production and eliminates coliform bacteria in cattle and swine waste. J Appl Microbiol 2004, 97, 1001–1005, doi: 10.1111/j.1365-2672.2004.02386.x.
Open DOI Search in Google Scholar Back to article
Vimalanathan S., Hudson J.: Anti-influenza virus activities of commercial oregano oils and their carriers. J Appl Pharm Sci 2012, 2, 214–218, doi: 10.7325/JAPS.2012.2734.
Open DOI Search in Google Scholar Back to article
Wei H.-K., Xue H.-X., Zhou Z.X., Peng J.: A carvacrol-thymol blend decreased intestinal oxidative stress and influenced selected microbes without changing the messenger RNA levels of tight junction proteins in jejunal mucosa of weaning piglets. Animal 2017, 11, 193–201, doi: 10.1017/S1751731116001397.
Open DOI Search in Google Scholar Back to article
Yang Z., Wang Y., He T., Ziema Bumbie G., Wu L., Sun Z., Sun W., Tang Z.: Effects of dietary Yucca schidigera extract and oral Candida utilis on growth performance and intestinal health of weaned piglets. Front Nutr 2021, 8, 685540, doi: 10.3389/fnut.2021.685540.
Open DOI Search in Google Scholar Back to article
Ye H., Shen S., Xu J., Lin S., Yuan Y., Jones G.S.: Synergistic interactions of cinnamaldehyde in combination with carvacrol against food-borne bacteria. Food Control 2013, 34, 619–623, doi: 10.1016/j.foodcont.2013.05.032.
Open DOI Search in Google Scholar Back to article
Zhao Y., Wei J., Li C., Ahmed A.F., Liu Z., Ma C.: A comprehensive review on mechanism of natural products against Staphylococcus aureus. J Future Foods 2022, 2, 25–33, doi: 10.1016/j.jfutfo.2022.03.014.
Open DOI Search in Google Scholar Back to article

DOI: https://doi.org/10.2478/jvetres-2025-0058 | Journal eISSN: 2450-8608

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Language: English

Submitted on: Apr 23, 2025

Accepted on: Oct 15, 2025

Published on: Oct 21, 2025

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Publication frequency: 4 times per year

Keywords:

biocide,

growth performance,

nutritional intervention,

Related subjects:

Microbiology and virology,

Life sciences, other,

Medicine,

Veterinary medicine

© 2025 Jarosław Wojciechowski, Dominika Siuda, Małgorzata Juszkiewicz, Ruud Schrijver, Javier Banuls Soto, René Bonekamp, Chandra Pareek, Zygmunt Pejsak, Grzegorz Woźniakowski, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution 4.0 License.

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