Results of the in vivo faecal egg count reduction test for pour-on eprinomectin and injectable ivermectin on eight goat farms
| Farm | Eggs per gram | Pour-on eprinomectin | Injectable ivermectin | ||||
|---|---|---|---|---|---|---|---|
| D0 | D14 | FECR% (95% CI lower and upper bounds) | D0 | D14 | FECR% (95% CI lower and upper bounds) | ||
| 1 | Mean ± SD | 725 ± 861.01 | 20.00 ± 33.16 | 96.60 (90, 99) | 470.00 ± 2 61.91 | 30.00 ± 45.82 | 93.60 (84, 98) |
| Min-max | 150–3,100 | 0–100 | 150–1,000 | 0–150 | |||
| 2 | Mean ± SD | 262.50 ± 143.06 | 125.00 ± 75.00 | 59.20 (20, 86) | 710.00 ± 339.70 | 130.00 ± 143.52 | 80.80 (47, 95) |
| Min-max | 150–500 | 0–200 | 150–1,100 | 0–350 | |||
| 3 | Mean ± SD | 2,810.00 ± 1,370.36 | 485.00 ± 597.93 | 87.10 (77, 93) | 2,261.11 ± 2,142.65 | 288.88 ± 334.81 | 89.20 (80, 95) |
| Min-max | 1400–5,300 | 0–2,000 | 800–8,150 | 0–1000 | |||
| 4 | Mean ± SD | 1,495.00 ± 720.57 | 100.00 ± 94.86 | 93.50 (87, 97) | 1,325.00 ± 835.16 | 75.00 ± 93.54 | 94.70 (87, 98) |
| Min-max | 250–2,550 | 0–300 | 350–2,950 | 0–250 | |||
| 5 | Mean ± SD | 970.00 ± 772.39 | 430.00 ± 448.99 | 63.50 (36, 81) | 545.00 ± 396.51 | 40.00 ± 76.81 | 92.30 (85, 96) |
| Min-max | 150–2,450 | 0–1,300 | 150–1,400 | 0–250 | |||
| 6 | Mean ± SD | 1,170.00 ± 506.55 | 430.00 ± 289.13 | 65.40 (39, 84) | 1,155.55 ± 981.33 | 116.66 ± 97.18 | 88.00 (73, 94) |
| Min-max | 250–2,150 | 0–750 | 200–3,550 | 0–350 | |||
| 7 | Mean ± SD | 1,711.11 ± 1,023.27 | 694.44 ± 381.84 | 51.00 (27, 69) | N/A | N/A | N/A |
| Min-max | 350–3,350 | 0–1,300 | |||||
| 8 | Mean ± SD | 612.50 ± 544.14 | 150.00 ± 141.42 | 69.40 (37, 91) | N/A | N/A | N/A |
| Min-max | 200–1,950 | 0–400 | |||||
The proportions of the gastrointestinal nematode third-stage larvae by species before and after treatment with pour-on eprinomectin and injectable ivermectin for the eight goat farms
| Farm | D0 (%) | D14 (%) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Eprinomectin | Ivermectin | |||||||||||
| HC | TEL | TR | OE/CHAB | HC | TEL | TR | OE/CHAB | HC | TEL | TR | OE/CHAB | |
| 1 | 25 | 55 | 15 | 5 | 100 | - | - | - | 100 | - | - | - |
| 2 | 42 | 45 | 9 | 4 | 97 | 3 | - | - | 100 | - | - | - |
| 3 | 13 | 65 | 8 | 14 | 100 | - | - | - | 100 | - | - | - |
| 4 | 28 | 53 | 7 | 12 | 100 | - | - | - | 100 | - | - | - |
| 5 | 68 | 21 | 11 | - | 100 | - | - | - | 100 | - | - | - |
| 6 | 36 | 49 | 12 | 3 | 100 | - | - | - | 100 | - | - | - |
| 7 | 31 | 59 | 8 | 2 | 95 | 5 | - | - | 100 | - | - | - |
| 8 | 56 | 37 | 5 | 2 | 100 | - | - | - | 100 | - | - | - |
The mean numbers of infective third-stage larvae at ivermectin concentrations equal to or higher than the minimum inhibitory concentration of 21_6 ng/mL for the eight goat farms
| Farm | Mean number of L3 larvae ± SD at concentrations ≥21.6 ng/mL |
|---|---|
| 1 | 3.50 ± 4.79 |
| 2 | 24.12 ± 4.42 |
| 3 | 22.75 ± 7.17 |
| 4 | 4.00 ± 1.87 |
| 5 | 5.75 ± 1.47 |
| 6 | 23.00 ± 11.92 |
| 7 | 5.25 ± 1.08 |
| 8 | 8.12 ± 2.84 |
Interpretation of World Association for the Advancement of Veterinary Parasitology guidelines for faecal egg count reduction test results
| Efficacy | Results |
|---|---|
| Reduced | FECR% < 95% confidence interval and <90% |
| Doubtful | Either FECR% < 95% or lower limit of the 95% confidence interval or <90% |
| Normal | FECR% ≥ 95% and lower limit of the 95% confidence interval and ≥ 90% |