Fig. 1.
Role of kisspeptin-10 (KiSS-10), neurokinin B (NKB) and dynorphin (Dyn) A in the endocrine regulation of puberty, based on Navarro (20) and Pinilla et al. (24) ARC – arcuate nucleus; KNDy – kisspeptin, neurokinin B and dynorphin; GPR54 – G protein-related membrane receptor 54; NK3R – neurokinin 3 receptor; KOR – kappa opioid receptor; GnRH – gonadotropin-releasing hormone; LH – luteinising hormone; FSH – follicle-stimulating hormone; + – positive action; − – negative action; ? – unknown action
Fig. 2.
Influence of kisspeptin-10 (10−11–10−7 M) on luteinising hormone (LH) secretion from ovine pituitary cells in vitro a, b, c – mean values obtained at a specific incubation time marked with different letters differ statistically significantly (P-value ≤ 0.05)
Fig. 3.
Influence of kisspeptin-10 (10−11–10−7 M) on follicle-stimulating hormone (FSH) secretion from ovine pituitary cells in vitro a, b – mean values obtained at a specific incubation time marked with different letters differ statistically significantly (P-value ≤ 0.05)
Fig. 4.
Influence of neurokinin B (10−11–10−7 M) on luteinising hormone (LH) secretion from ovine pituitary cells in vitro a, b – mean values obtained at a specific incubation time marked with different letters differ statistically significantly (P-value ≤ 0.05)
Fig. 5.
Influence of neurokinin B (10−11–10−7 M) on follicle-stimulating hormone (FSH) secretion from ovine pituitary cells in vitro a, b – mean values obtained at a specific incubation time marked with different letters differ statistically significantly (P-value ≤ 0.05)
Fig. 6.
Influence of dynorphin A (10−11–10−7 M) on luteinising hormone (LH) secretion from ovine pituitary cells in vitro a, b – mean values obtained at a specific incubation time marked with different letters differ statistically significantly (P-value ≤ 0.05)
Fig. 7.
Influence of dynorphin A (10−11–10−7 M) on follicle-stimulating hormone (FSH) secretion from ovine pituitary cells in vitro a, b, c – mean values obtained at a specific incubation time marked with different letters differ statistically significantly (P-value ≤ 0.05)