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The diagnostic value of selected immune parameters in peripheral blood of dogs with malignant mammary tumours – a preliminary study Cover

The diagnostic value of selected immune parameters in peripheral blood of dogs with malignant mammary tumours – a preliminary study

Journal of Veterinary Research
Volume 68 (2024): Issue 2 (June 2024)
By: Urszula Lisiecka,  Piotr Brodzki,  Anna Śmiech,  Katarzyna Michalak,  Stanisław Winiarczyk,  Beata Żylińska and  Łukasz Adaszek  
Open Access
|Jun 2024
Figures & tables

Figures & Tables

Fig. 1.

Frequencies of CD3+ T lymphocytes (A) and CD21+ B lymphocytes (B), and the CD3+/CD21+ lymphocyte ratio (C) in blood from canine mammary tumour patients and healthy controls. Mean and median percentages of cells in the control group (H), in the group without metastases (WM), and in the group with metastases (M). Boxes cover the 25th–75th percentiles and the median is shown as a line across the box * – statistically significant difference (P-value < 0.05) between group WM and group M; X – statistically significant difference (P-value < 0.05) between groups WM or M and group H

Fig. 2.

Frequencies of CD4+ T helper lymphocytes (A) and CD8+ cytotoxic T lymphocytes (B), and the CD4+/CD8+ lymphocyte ratio (C) in blood from canine mammary tumour patients and healthy controls. Mean and median percentages of cells in the control group (H), in the group without metastases (WM), and in the group with metastases (M). Boxes cover the 25th–75th percentiles and the median is shown as a line across the box * – statistically significant difference (P-value < 0.05) between group WM and group M; X – statistically significant difference (P-value < 0.05) between groups WM or M and group H

Descriptive statistics of variables (full sample set n = 30)

VariableHealth statusMeanMedianSDSEMinimumMaximumANOVA P-valueTukey pairsTukey P-values
% CD3+without metastasis66.669.38.92.852.780.60.0003H vs MWM vs M0.0010.0011
metastasis46.146.414.74.722.368.9
healthy66.767.19.32.952.585.1
% CD21+without metastasis8.58.62.50.85.211.90.0018H vs M WM vs M0.01390.0021
metastasis20.117.910.43.38.438.2
healthy10.910.94.91.64.621.4
% CD4+without metastasis35.534.99.53.022.650.40.0002H vs WMWM vs M 0.00020.0061
metastasis23.225.98.32.610.334.6
healthy40.442.36.22.031.452.0
% CD8+without metastasis20.719.48.02.59.535.4No statistically significant difference
metastasis19.320.39.02.84.536.4
healthy18.418.32.30.715.121.9
CD3+/CD21+ratiowithout metastasis8.58.62.80.94.413.30.0028H vs MWM vs M0.01250.0041
metastasis3.02.72.10.70.68.1
healthy7.86.54.91.52.818.0
CD4+/CD8+ ratiowithout metastasis1.91.90.90.30.83.30.0348H vs M0.03291
metastasis1.41.30.50.20.62.3
healthy1.22.20.70.21.43.4

Characteristics of canine patients enrolled in the study

CharacteristicsNumber of patients with different stages of tumour
Without metastases (N0M0)With metastases (N1, N0M1 or N1M1)
G1 complex carcinoma20
G2 complex carcinoma22
G1 tubular carcinoma32
G2 tubular carcinoma23
osteosarcoma13
DOI: https://doi.org/10.2478/jvetres-2024-0035 | Journal eISSN: 2450-8608
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Language: English
Page range: 271 - 278
Submitted on: Mar 28, 2024
Accepted on: Jun 13, 2024
Published on: Jun 20, 2024
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
canine mammary tumours,
flow cytometry,
immunophenotyping,
lymphocyte subsets,
metastasis biomarkers
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2024 Urszula Lisiecka, Piotr Brodzki, Anna Śmiech, Katarzyna Michalak, Stanisław Winiarczyk, Beata Żylińska, Łukasz Adaszek, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 68 (2024): Issue 2 (June 2024)
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