Antibody response to 1.0 and 0.5 mL doses of an inactivated bacterial vaccine against bovine respiratory disease in young Holstein calves: a field trial Cover

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Antibody response to 1.0 and 0.5 mL doses of an inactivated bacterial vaccine against bovine respiratory disease in young Holstein calves: a field trial

Journal of Veterinary Research

Volume 67 (2023): Issue 3 (September 2023)

By: Kazusa Mori, Toshihide Kato, Keigo Kosenda, Osamu Yokota and Hiromichi Ohtsuka

Open Access

|Sep 2023

Figures & Tables

Antibody responses in young Holstein calves vaccinated with a dose of 1.0 mL or 0.5 mL of an inactivated bacterial vaccine against bovine respiratory disease PV-Control - primary-vaccination control; NV-Control - no-vaccination control; arrows – vaccination times; **, * – significant increase compared to titre at one week of age (P < 0.01, P < 0.05); †† – significant decrease compared to titre at one week of age (P < 0.01); A-B, X-Y, a-b, x-y, α-β, χ-ψ – differences in final antibody titres (P < 0.01, P < 0.01, P < 0.05, P < 0.05, P < 0.10, and P < 0.10, respectively)

Standardised regression coefficients from the logistic regression for seropositivity Primary – primary vaccination; Booster – booster vaccination; * – P < 0.05

Body mass index (BMI) values for the experimental and control groups of young Holstein calves and null hypothesis validity of the values

Group	BMI	P-value
Group	BMI	1.0 + 1.0	0.5 + 1.0	0.5 + 0.5	PV-Control	NV-Control
1.0 + 1.0	64.9 ± 0.8	1	0.898	1.000	0.731	0.715
0.5 + 1.0	64.0 ± 0.9	0.898	1	0.975	0.568	0.534
0.5 + 0.5	64.6 ± 0.8	1.000	0.975	1	0.731	0.584
PV-Control	66.8 ± 1.5	0.731	0.568	0.731	1	0.999
NV-Control	66.8 ± 1.7	0.715	0.534	0.584	0.999	1

The number of calves with high and low maternal antibody levels and with positive and negative vaccine responses to (a) H_ somni, (b) P_ multocida and (c) M_ haemolytica

(a)	One week of age			Seven weeks of age
H. somni	High MAL	Low MAL	P-value	Positive	Negative	P-value
1.0 + 1.0	0	14	−	11	3	0.005^**
0.5 + 1.0	0	14	−	12	2	0.000^**
0.5 + 0.5	0	14	−	5	9	0.556
PV-Control	0	12	−	1	11	0.008^**
NV-Control	0	12	−	0	12	0.000^**
P-value		1.000			0.000^**
(b)	One week of age			Seven weeks of age
P. multocida	High MAL	Low MAL	P-value	Positive	Negative	P-value
1.0 + 1.0	9	5	−	14	0	0.015^*
0.5 + 1.0	4	10	−	14	0	0.015^*
0.5 + 0.5	6	8	−	13	1	0.159
PV-Control	7	5	−	5	7	0.006^**
NV-Control	6	6	−	4	8	0.000^**
P-value		0.402			0.000^**
(c)	One week of age			Seven weeks of age
M. haemolytica	High MAL	Low MAL	P-value	Positive	Negative	P-value
1.0 + 1.0	9	5	−	2	12	−
0.5 + 1.0	6	8	−	3	11	−
0.5 + 0.5	12	2	−	2	12	−
PV-Control	5	7	−	0	12	−
NV-Control	6	6	−	0	12	−
P-value		0.104			0.275

Dosages of the vaccine and sample size

Group	Dose at one week of age	Dose at four weeks of age	Sample size
1.0 + 1.0	1.0 mL	1.0 mL	n = 14
0.5 + 1.0	0.5 mL	1.0 mL	n = 14
0.5 + 0.5	0.5 mL	0.5 mL	n = 14
PV-Control	Not vaccinated	1.0 mL	n = 12
NV-Control	Not vaccinated	Not vaccinated	n = 12

DOI: https://doi.org/10.2478/jvetres-2023-0037 | Journal eISSN: 2450-8608

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Language: English

Page range: 315 - 321

Submitted on: Jan 31, 2023

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Accepted on: Jun 19, 2023

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Published on: Sep 20, 2023

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

bovine respiratory disease,

early vaccination,

Related subjects:

Molecular biology,

Microbiology and virology,

Life sciences, other,

Veterinary medicine

© 2023 Kazusa Mori, Toshihide Kato, Keigo Kosenda, Osamu Yokota, Hiromichi Ohtsuka, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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