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Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility ex vivo Cover

Diclofenac and dexamethasone modulate the effect of cannabidiol on the rat colon motility ex vivo

Journal of Veterinary Research
Volume 67 (2023): Issue 2 (June 2023)
By: Magdalena Chłopecka,  Łukasz Kiraga,  Kijan Crowley,  Michał Jank,  Urszula Latek,  Marta Mendel and  Wojciech Karlik  
Open Access
|Jun 2023

Figures & Tables

Fig. 1.

Example recording of a rat distal colon strip’s reactivity to acetylcholine (ACh) in the presence of modified Krebs–Henseleit solution (control reaction) and cannabidiol (CBD). F – flushing
Example recording of a rat distal colon strip’s reactivity to acetylcholine (ACh) in the presence of modified Krebs–Henseleit solution (control reaction) and cannabidiol (CBD). F – flushing

Fig. 2.

Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), diclofenac (DCF) and DCF with cannabidiol (CBD). F – flushing
Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), diclofenac (DCF) and DCF with cannabidiol (CBD). F – flushing

Fig. 3.

Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), dexamethasone (DEX) and DEX with cannabidiol (CBD). F – flushing
Example recording of a rat distal colon strip’s reactivity to acetylcholine (Ach) in the presence of modified Krebs–Hanseleit solution (control reaction), dexamethasone (DEX) and DEX with cannabidiol (CBD). F – flushing

Fig. 4.

Comparison of the effects of tested substances on rat colon contractility relative to control acetylcholine administration; (a) Cannabidiol (CBD), diclofenac (DCF) and dexamethasone (DEX) administered alone; (b) CBD, DCF and DEX administered in combinations. Data are expressed as the mean of independent experiments; n = 5, ± standard deviation. Asterisks indicate a statistically significant difference at the level of P ≤ 0.05 (*), P<0.01 (**), P ≤ 0.001 (***) or P ≤ 0.0001 (****)
Comparison of the effects of tested substances on rat colon contractility relative to control acetylcholine administration; (a) Cannabidiol (CBD), diclofenac (DCF) and dexamethasone (DEX) administered alone; (b) CBD, DCF and DEX administered in combinations. Data are expressed as the mean of independent experiments; n = 5, ± standard deviation. Asterisks indicate a statistically significant difference at the level of P ≤ 0.05 (*), P<0.01 (**), P ≤ 0.001 (***) or P ≤ 0.0001 (****)
DOI: https://doi.org/10.2478/jvetres-2023-0029 | Journal eISSN: 2450-8608
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Language: English
Page range: 289 - 295
Submitted on: Dec 14, 2022
Accepted on: May 12, 2023
Published on: Jun 16, 2023
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
cannabidiol,
additive synergism,
intestinal motility,
isolated rat colon strips
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2023 Magdalena Chłopecka, Łukasz Kiraga, Kijan Crowley, Michał Jank, Urszula Latek, Marta Mendel, Wojciech Karlik, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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