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Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status Cover

Field trial of antibody response to inactivated bacterial vaccine in young Holstein calves: influence of animal health status

Journal of Veterinary Research
Volume 66 (2022): Issue 1 (March 2022)
By: Kazusa Mori,  Konosuke Otomaru,  Toshihide Kato,  Osamu Yokota and  Hiromichi Ohtsuka  
Open Access
|Mar 2022

Figures & Tables

Fig. 1

BMI of the positive and negative group calves at the primary and booster immunisation in the first experiment. * – P < 0.05; ** – P < 0.01; # – P = 0.062
BMI of the positive and negative group calves at the primary and booster immunisation in the first experiment. * – P < 0.05; ** – P < 0.01; # – P = 0.062

Fig. 2

Relationship between body mass index at primary immunisation and maternal antibody titre against Histophilus somni at primary immunisation; post-immunisation titre and maternal antibody titre at primary immunisation against H. somni; post-immunisation titre against H. somni and body mass index at primary immunisation; and post-immunisation titre against H. somni and body mass index at booster vaccination in the first experiment (1) and between maternal antibody titre and serum total protein or gamma globulin at the primary immunisation in the second experiment (2). ** – P < 0.01; # – P < 0.10
Relationship between body mass index at primary immunisation and maternal antibody titre against Histophilus somni at primary immunisation; post-immunisation titre and maternal antibody titre at primary immunisation against H. somni; post-immunisation titre against H. somni and body mass index at primary immunisation; and post-immunisation titre against H. somni and body mass index at booster vaccination in the first experiment (1) and between maternal antibody titre and serum total protein or gamma globulin at the primary immunisation in the second experiment (2). ** – P < 0.01; # – P < 0.10

The number of positive and negative calves following immunisation (a) in each experiment and (b) for each MAL in the first experiment

(a)ExperimentAntibody titreBMINutritional statusOxidative stressPositiveNegative
First✓✓ 7730
H. somniSecond✓✓✓ 4125
Third✓✓✓✓2522
First✓✓ 1016
P. multocidaSecond✓✓✓ 615
Third✓✓✓✓425
First✓✓ 3770
M. haemolyticaSecond✓✓✓ 858
Third✓✓✓✓839
(b) MALPositiveNegative P value
5038 4
10045 1
P. multocida 20015 1 -
4003 0
503 16 0.058
1009 28 0.105
M. haemolytica** 20012 19 0.566
40011 7 0.009**
8002 0 0.050*

Pearson’s correlation analysis

First experiment Maternal antibody titre
Body mass index
Post-immunisation titre
H.P.M.AtAtH.P.M.
somnimultocidahaemolyticaprimaryboostersomnimultocidahaemolytica
Maternal antibody titreH. somni-
P. multocida0.530**-
M. haemolytica0.438**0.492**-
At primary0.1820.0480.198*-
Body mass indexAt booster0.362**0.298**0.208*0.446**-
H. somni0.1320.1520.1420.316**0.383**-
Post-immunisationP. multocida−0.0330.1320.0850.370**0.347**0.452**-
titreM. haemolytica0.0610.227*0.264**0.389**0.278**0.357**0.510**-

The nutritional status in the second experiment (a) and oxidative stress marker values in the third experiment (b)

(a) H. somni
P. multocida
M.haemolytica
PositiveNegativePositiveNegativePositiveNegative
Total cholesterolP93.6 ± 5.398.5 ± 5.196.1 ± 4.088.2 ± 13.479.3 ± 8.397.7 ± 4.1
(mg/dL)B118.3 ± 5.2118.6 ± 4.6118.7 ± 3.8114.4 ± 12.8113.8 ± 10.0119.0 ± 3.9
Blood urea nitrogenP12.1 ± 0.710.9 ± 0.411.7 ± 0.510.4 ± 0.613.3 ± 2.311.4 ± 0.5
(mg/dL)B9.3 ± 0.310.4 ± 0.49.6 ± 0.211.4 ± 0.49.3 ± 0.69.8 ± 0.2
Total proteinP5.8 ± 0.1*5.6 ± 0.15.7 ± 0.15.5 ± 0.26.0 ± 0.25.7 ± 0.1
(g/dL)B6.0 ± 0.15.9 ± 0.16.0 ± 0.06.1 ± 0.26.0 ± 0.16.0 ± 0.0
Albumin/globulinP1.04 ± 0.031.08 ± 0.041.05 ± 0.031.11 ± 0.100.91 ± 0.08*1.08 ± 0.02
ratioB1.15 ± 0.031.17 ± 0.031.16 ± 0.021.14 ± 0.081.07 ± 0.031.17 ± 0.02
AlbuminP2.90 ± 0.042.87 ± 0.052.89 ± 0.032.87 ± 0.102.76 ± 0.082.91 ± 0.04
(g/dL)B3.19 ± 0.033.16 ± 0.043.18 ± 0.033.25 ± 0.093.11 ± 0.063.19 ± 0.03
Alpha globulinP1.06 ± 0.021.07 ± 0.031.06 ± 0.021.11 ± 0.071.15 ± 0.081.06 ± 0.02
(g/dL)B0.97 ± 0.020.99 ± 0.020.97 ± 0.021.04 ± 0.050.99 ± 0.030.97 ± 0.02
Beta globulinP1.00 ± 0.030.99 ± 0.031.00 ± 0.020.91 ± 0.061.05 ± 0.070.99 ± 0.02
(g/dL)B1.01 ± 0.021.01 ± 0.021.01 ± 0.011.04 ± 0.051.01 ± 0.051.01 ± 0.01
Gamma globulinP0.81 ± 0.05*0.65 ± 0.060.76 ± 0.040.63 ± 0.120.98 ± 0.15*0.72 ± 0.04
(g/dL)B0.83 ± 0.03*0.75 ± 0.040.80 ± 0.030.79 ± 0.070.92 ± 0.090.78 ± 0.03
DOI: https://doi.org/10.2478/jvetres-2022-0003 | Journal eISSN: 2450-8608
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Language: English
Page range: 109 - 116
Submitted on: Jul 4, 2021
Accepted on: Jan 11, 2022
Published on: Mar 25, 2022
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
early vaccination,
bovine respiratory disease,
maternal antibody,
nutritional status,
oxidative stress
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2022 Kazusa Mori, Konosuke Otomaru, Toshihide Kato, Osamu Yokota, Hiromichi Ohtsuka, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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