| 1 | After three weeks of | Thirteen months | Moderate liver | Lymphoplasmacytic periportal | Negative |
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| treatment, cessation of | after treatment | enlargement and | hepatitis with proliferating bile |
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| crepitant rale at rest, | completion, placed | yellowing, grey foci up | ductules, cholestasis; chronic |
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| occurrence of vocalisations; | in a cage with | to 1 mm on the liver | enteritis; |
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| after two months, cessation | a female, which laid | surface, | focal myocarditis and fibrosis; |
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| of signs of stress-induced | normal eggs. | cholecystolithiasis, | membranoproliferative |
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| dyspnoea. | Fifteen months after | renal oedema, right |
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| During treatment, two | treatment | ventricle dilation, | glomerulopathy, bile droplets in |
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| periods of watery diarrhoea: | completion, | inactive testes. | tubular epithelial cells; |
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| at the beginning | dwelling on the |
| splenic lymphoid depletion; |
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| of treatment and one month | bottom of the cage, |
| neuronal damage and gliosis. |
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| after treatment initiation. | hypothermia, |
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| Bird showing susceptibility | polyuria, |
| ZN-negative |
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| to stress. | polydypsia, |
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| anorexia. |
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| 2 | One month before treatment | One month after | Moderately good | Hepatic lipidosis; chronic enteritis; | Negative |
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| completion, neurological | treatment | nutrition status, loss of | fat droplets in renal epithelial cells; |
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| signs occurred. The signs | completion, after 10 | forebrain and | splenic lymphoid depletion; |
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| receded following | days of supportive | hydrocephalus, liver | neuronal damage, gliosis, focal |
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| supportive treatment. | treatment, | yellowing and slight | vacuolation of neuropil and |
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| neurological signs | enlargement, slight | oedema. |
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| returned. The | kidney and spleen |
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| canary was | oedema, inactive testes. | ZN-negative |
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| euthanised. |
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| 3 | Complete cessation of | Prolonged periods | Moderately good | Multifocal to coalescing hepatic | Positive |
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| dyspnoea after 26 days of | of moulting. | nutrition status, | granulomas; |
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| treatment. | Periodic post- | significant hepato- and | intestinal crypt loss, fibrosis of the |
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| exercise dyspnoea. | splenomegaly, paleness | lamina propria, and focal |
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| Fourteen months | of the liver and spleen, | granulomatous enteritis; |
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| after treatment, | inactive testes. |
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| moderately |
| mesangioproliferative |
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| numerous AFB in |
| glomerulopathy, necrotic tubular |
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| faeces, significant |
| epithelial cells, lymphoid follicle |
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| liver enlargement. |
| formation in the interstitial tissue; |
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| splenic coalescing granulomas; |
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| a few mononuclear cells aggregated |
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| closely to the leptomeninges, |
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| gliosis and neuronal damage. |
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| ZN-positive (liver, pancreas, |
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| intestine, kidney, spleen and lungs). |
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| 4 | Good health throughout the | Prolonged periods | Not tested | Not tested | Not tested |
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| treatment period. | of moulting. |
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| 5 | Found dead after two weeks | N/a | N/a | Fungal pneumonia; | Positive |
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| of treatment. |
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| neuronal damage and gliosis. |
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| A mistake in the procedure of |
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| fixing the remaining tissues |
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| prevented their histopathological |
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| evaluation. |
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| ZN-positive (liver, spleen and lungs |
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| in cytology). |
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| 6 | Good condition throughout | - | Good nutrition status | Hepatic lipidosis, proliferation of | Positive |
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| the treatment period with |
| and musculature, | bile ducts, cholestasis fibrinoid |
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| beak hyperplasia requiring |
| moderate spleen | necrosis of vascular walls; chronic |
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| correction. Four months |
| enlargement, active | enteritis; |
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| after treatment initiation, the |
| testes. | splenic lymphoid depletion, |
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| bird died owing to |
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| vascular fibrinoid necrosis; |
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| haemorrhage after blood |
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| membranoproliferative |
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| sampling from the external |
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| glomerulopathy, |
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| jugular vein. |
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| bile droplets in tubular epithelial |
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| cells; |
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| neuronal damage and gliosis. |
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| ZN negative |
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