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Tk-deleted pseudorabies virus retains high pathogenicity in rats Cover

Tk-deleted pseudorabies virus retains high pathogenicity in rats

Journal of Veterinary Research
Volume 65 (2021): Issue 4 (December 2021)
By:
Open Access
|Oct 2021

Figures & Tables

Fig. 1

The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group) A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247; C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012
The survival rate of the rats infected with PRV JS-2012 or SuHV-1 ΔTK:247. The percentage of surviving rats is presented as a Kaplan-Meier plot (n = 6 per group) A - rats intranasally inoculated with the tk-deleted PRV strain, SuHV-1 ΔTK:247; B - rats intramuscularly inoculated with SuHV-1 ΔTK:247; C - rats intranasally inoculated with the wild-type PRV strain, JS-2012; D - rats intramuscularly inoculated with JS-2012

Fig. 2

The viral loads in different tissues of rats infected with PRV JS-2012 or SuHV-1ΔTK:247, respectively. The rats in each group (n = 6 per group) were infected with JS-2012 and SuHV-1 ΔTK:247 at different doses via intranasal or intramuscular inoculation. Ten tissues were collected from dead and surviving rats, and subjected to viral load analysis. Viral copies were determined by qPCR. Data are presented as the mean ± SD from six rats per group. *** - P < 0.001 versus other tissues of rats infected with 105 TCID50 PRV; ### - P < 0.001 and ## - P < 0.01 versus the same tissues of rats infected with other doses of PRV
The viral loads in different tissues of rats infected with PRV JS-2012 or SuHV-1ΔTK:247, respectively. The rats in each group (n = 6 per group) were infected with JS-2012 and SuHV-1 ΔTK:247 at different doses via intranasal or intramuscular inoculation. Ten tissues were collected from dead and surviving rats, and subjected to viral load analysis. Viral copies were determined by qPCR. Data are presented as the mean ± SD from six rats per group. *** - P < 0.001 versus other tissues of rats infected with 105 TCID50 PRV; ### - P < 0.001 and ## - P < 0.01 versus the same tissues of rats infected with other doses of PRV
DOI: https://doi.org/10.2478/jvetres-2021-0056 | Journal eISSN: 2450-8608
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Language: English
Page range: 401 - 405
Submitted on: Apr 2, 2021
Accepted on: Oct 12, 2021
Published on: Oct 26, 2021
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
pseudorabies virus,
thymidine kinase,
rat
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2021 Lirong Zhang, Keyue Ruan, Guoju Sang, Zhaoyang Xu, Wu Tong, Hai Yu, Tongling Shan, Fei Gao, Liwei Li, Ning Kong, Guangzhi Tong, Hao Zheng, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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