Spontaneous alteration of blood pH by a bicarbonate buffer system during experimental hypercalcaemia in cows Cover

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Spontaneous alteration of blood pH by a bicarbonate buffer system during experimental hypercalcaemia in cows

Journal of Veterinary Research

Volume 65 (2021): Issue 4 (December 2021)

By: Younghye Ro, Woojae Choi, Leegon Hong, Eunkyung Kim, Eunhui Choe and Danil Kim

Open Access

|Oct 2021

Figures & Tables

Changes in plasma mineral concentrations, urinary mineral excretions, and blood gas parameters in the control group (CON) and induced hypercalcaemic group (HYC)A – Ca concentration in plasma; B – Ca excretion through urine (Ca/creatine (crea)); C – Mg concentration in plasma; D – Mg excretion through urine (Mg/crea); E – blood pH; F – bicarbonate (HCO3−); G – partial pressure of carbon dioxide (pCO2); H – ionised Ca. Data are expressed as means ± standard deviation. * – significant difference compared to 0h (P < 0.05); ** – significant difference compared to 0 h (P < 0.001); a – significant difference compared to CON (P < 0.05); b – significant difference compared to CON (P < 0.001)

Results of Pearson correlation analysis of Ca concentration with pH in the induced hypercalcaemic group

		Test (n)	iCa	Ca/crea	pH	HCO₃⁻	pCO₂
Ca	r value		0.933	0.846	0.688	0.672	0.206

	(P value)	45	(<0.001)^**	(<0.001)^**	(<0.001)^**	(<0.001)^**	(0.174)

iCa	r value	45		0.860	0.542	0.549	0.194

	(P value)			(<0.001)^**	(<0.001)^**	(<0.001)^**	(0.201)

Ca/crea	r value				0.511	0.486	0.125

	(P value)	45			(<0.001)^**	(<0.001)^**	(0.412)

pH	r value	45				0.820	0.041

	(P value)					(<0.001)^**	(0.788)

HCO₃^-	r value						0.603

	(P value)	45					(<0.001)^**

Results of Pearson correlation analysis of parameters in blood analyses in all individuals

		Test (n)	Mg	Ca/crea	Mg/crea	iCa	pH	HCO₃⁻	pCO₂
Ca	r value		0.599	0.825	0.698	0.917	0.466	0.490	0.220
Ca
	(P value)	90	(<0.001)^**	(<0.001)^**	(<0.001)^**	(<0.001)^**	(<0.001)^**	(<0.001)^**	(0.037)^*

Mg	r value			0.381	0.438	0.410	0.340	0.262	0.004
Mg
	(P value)	90		(<0.001)^**	(<0.001)^**	(<0.001)^**	(0.001)^*	(0.013)^*	(0.971)

Ca/crea	r value				0.891	0.857	0.370	0.382	0.161
Ca/crea
	(P value)	90			(<0.001)^**	(<0.001)^**	(<0.001)^**	(<0.001)^**	(0.131)

Mg/crea	r value					0.712	0.345	0.380	0.181
Mg/crea
	(P value)	90				(<0.001)^**	(<0.001)^**	(<0.001)^**	(0.088)

iCa	r value						0.309	0.348	0.175
iCa
	(P value)	90					(0.003)^*	(<0.001)^**	(0.098)

pH	r value							0.781	0.085
pH
	(P value)	90						(<0.001)^**	(0.424)

⁻ HCO₃	r value								0.687
⁻ HCO₃
	(P value)	90							(<0.001)^**

DOI: https://doi.org/10.2478/jvetres-2021-0053 | Journal eISSN: 2450-8608

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Language: English

Page range: 539 - 543

Submitted on: Mar 17, 2021

Accepted on: Sep 23, 2021

Published on: Oct 1, 2021

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

hypercalcaemia,

bicarbonate buffer system

Related subjects:

Molecular biology,

Microbiology and virology,

Life sciences, other,

Veterinary medicine

© 2021 Younghye Ro, Woojae Choi, Leegon Hong, Eunkyung Kim, Eunhui Choe, Danil Kim, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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