Fig 1
Changes in plasma mineral concentrations, urinary mineral excretions, and blood gas parameters in the control group (CON) and induced hypercalcaemic group (HYC)
A – Ca concentration in plasma; B – Ca excretion through urine (Ca/creatine (crea)); C – Mg concentration in plasma; D – Mg excretion through urine (Mg/crea); E – blood pH; F – bicarbonate (HCO3−); G – partial pressure of carbon dioxide (pCO2); H – ionised Ca. Data are expressed as means ± standard deviation. * – significant difference compared to 0h (P < 0.05); ** – significant difference compared to 0 h (P < 0.001); a – significant difference compared to CON (P < 0.05); b – significant difference compared to CON (P < 0.001)
Table 1
Results of Pearson correlation analysis of parameters in blood analyses in all individuals
| Test (n) | Mg | Ca/crea | Mg/crea | iCa | pH | HCO3− | pCO2 | ||
|---|---|---|---|---|---|---|---|---|---|
| Ca | r value | 0.599 | 0.825 | 0.698 | 0.917 | 0.466 | 0.490 | 0.220 | |
| (P value) | 90 | (<0.001)** | (<0.001)** | (<0.001)** | (<0.001)** | (<0.001)** | (<0.001)** | (0.037)* | |
| Mg | r value | 0.381 | 0.438 | 0.410 | 0.340 | 0.262 | 0.004 | ||
| (P value) | 90 | (<0.001)** | (<0.001)** | (<0.001)** | (0.001)* | (0.013)* | (0.971) | ||
| Ca/crea | r value | 0.891 | 0.857 | 0.370 | 0.382 | 0.161 | |||
| (P value) | 90 | (<0.001)** | (<0.001)** | (<0.001)** | (<0.001)** | (0.131) | |||
| Mg/crea | r value | 0.712 | 0.345 | 0.380 | 0.181 | ||||
| (P value) | 90 | (<0.001)** | (<0.001)** | (<0.001)** | (0.088) | ||||
| iCa | r value | 0.309 | 0.348 | 0.175 | |||||
| (P value) | 90 | (0.003)* | (<0.001)** | (0.098) | |||||
| pH | r value | 0.781 | 0.085 | ||||||
| (P value) | 90 | (<0.001)** | (0.424) | ||||||
| − HCO3 | r value | 0.687 | |||||||
| (P value) | 90 | (<0.001)** |
[i] r – Pearson’s correlation coefficient values; * – significant difference between the hypercalcaemic group and the control group at P < 0.05; ** – significant difference between the hypercalcaemic group and the control group at P < 0.001; Ca/crea – calcium/creatinine in urine; Mg/crea – magnesium/creatinine in urine; iCa – ionised calcium; HCO3− – bicarbonate; pCO2, – partial pressure of carbon dioxide
Table 2
Results of Pearson correlation analysis of Ca concentration with pH in the induced hypercalcaemic group
| Test (n) | iCa | Ca/crea | pH | HCO3− | pCO2 | ||
|---|---|---|---|---|---|---|---|
| Ca | r value | 0.933 | 0.846 | 0.688 | 0.672 | 0.206 | |
| (P value) | 45 | (<0.001)** | (<0.001)** | (<0.001)** | (<0.001)** | (0.174) | |
| iCa | r value | 45 | 0.860 | 0.542 | 0.549 | 0.194 | |
| (P value) | (<0.001)** | (<0.001)** | (<0.001)** | (0.201) | |||
| Ca/crea | r value | 0.511 | 0.486 | 0.125 | |||
| (P value) | 45 | (<0.001)** | (<0.001)** | (0.412) | |||
| pH | r value | 45 | 0.820 | 0.041 | |||
| (P value) | (<0.001)** | (0.788) | |||||
| HCO3- | r value | 0.603 | |||||
| (P value) | 45 | (<0.001)** |
[i] r – Pearson’s correlation coefficient values; * – significant difference between the hypercalcaemic group and the control group at P < 0.05; ** – significant difference between the hypercalcaemic group and the control group at P < 0.001; Ca/crea – calcium/creatinine in urine; iCa – ionised calcium; HCO3− – bicarbonate; pCO2 – partial pressure of carbon dioxide