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Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway Cover

Porcine epidemic diarrhoea virus induces cell-cycle arrest through the DNA damage-signalling pathway

Journal of Veterinary Research
Volume 64 (2020): Issue 1 (March 2020)
By: Yi-Ran Luo,  Shu-Ting Zhou,  Liang Yang,  Yuan-Ping Liu,  Sheng-Yao Jiang,  Yeliboli Dawuli,  Yi-Xuan Hou,  Tian-Xing Zhou and  Zhi-Biao Yang  
Open Access
|Mar 2020

Figures & Tables

Fig. 1

A – analysis workflow for flow cytometry data; B – changes in cell cycle of Vero cells infected with PEDV between 0 h and 32 h after infection
A – analysis workflow for flow cytometry data; B – changes in cell cycle of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 2

changes in proportion of cells in the G1/G0 phase of Vero cells infected with PEDV between 0 h and 32 h after infection
changes in proportion of cells in the G1/G0 phase of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 3

Changes in proportion of cells in the S phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Changes in proportion of cells in the S phase of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 4

Changes in proportion of cells in the G2/M phase of Vero cells infected with PEDV between 0 h and 32 h after infection
Changes in proportion of cells in the G2/M phase of Vero cells infected with PEDV between 0 h and 32 h after infection

Fig. 5

Changes over time in Cyclin B1, D1, and E1 in Vero cells infected with PEDV (M – control; I – PEDV infected cells)
Changes over time in Cyclin B1, D1, and E1 in Vero cells infected with PEDV (M – control; I – PEDV infected cells)

Fig. 6

Changes over time in Chk.2, H2A.X, p53, and PEDV-N in Vero cells infected with PEDV (M – control, I – PEDV infected cells)
Changes over time in Chk.2, H2A.X, p53, and PEDV-N in Vero cells infected with PEDV (M – control, I – PEDV infected cells)

Fig. 7

Cell cycle data of control or PEDV-infected Vero cells treated by DMSO, ATM inhibitor, or/ and Chk.2 inhibitor
Cell cycle data of control or PEDV-infected Vero cells treated by DMSO, ATM inhibitor, or/ and Chk.2 inhibitor

Fig. 8

Virus proliferation evaluated by real-time PCR of control or PEDV infected Vero cells treated by DMSO, ATM inhibitor or Chk.2 inhibitor
Virus proliferation evaluated by real-time PCR of control or PEDV infected Vero cells treated by DMSO, ATM inhibitor or Chk.2 inhibitor
DOI: https://doi.org/10.2478/jvetres-2020-0024 | Journal eISSN: 2450-8608
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Language: English
Page range: 25 - 32
Submitted on: Jun 7, 2019
|
Accepted on: Mar 9, 2020
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Published on: Mar 24, 2020
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
porcine epidemic diarrhoea virus,
cell cycle,
virus proliferation,
DNA damage,
signalling pathways
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2020 Yi-Ran Luo, Shu-Ting Zhou, Liang Yang, Yuan-Ping Liu, Sheng-Yao Jiang, Yeliboli Dawuli, Yi-Xuan Hou, Tian-Xing Zhou, Zhi-Biao Yang, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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