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Histopathological evaluation of polycaprolactone nanocomposite compared with tricalcium phosphate in bone healing Cover

Histopathological evaluation of polycaprolactone nanocomposite compared with tricalcium phosphate in bone healing

Journal of Veterinary Research
Volume 62 (2018): Issue 3 (September 2018)
By: ,  ,  ,   and    
Open Access
|Oct 2018
Figures & tables

Figures & Tables

Table 1

Statistical analysis of union index

Group Day153045
Control0.2 ± 0.4471 ± 0.7072 ± 0.707
Hydroxyapatite0.8 ± 0.8362 ± 0.7072.6 ± 0.894
β-tricalcium phosphate1 ± 0.7072.6 ± 1.143.4 ± 0.894
Nanocomposite polycaprolactone1.8 ± 0.8363.4 ± 0.5473.8 ± 0.447
Table 2

Average union indices

GroupnumberAverage scoreTest statisticsdfSig
54
Control57.99.00920.011
512.1
54.1
Hydroxyapatite58.67.13820.028
511.3
53.7
β-tricalcium
58.88.25820.016
phosphate
511.5
53.4
Nanocomposite
9.50820.009
polycaprolactone59.2
511.4
Table 3

Statistical analysis of spongiosa index

Group Day153045
Control0.2 ± 0.4470.8 ± 0.8362 ± 0.707
Hydroxyapatite0.6 ± 0.5471.2 ± 0.4472.8 ± 0.836
β-tricalcium phosphate1 ± 0.7072.2 ± 0.4473.2 ± 0.447
Nanocomposite polycaprolactone1.4 ± 0.5473 ± 13.8 ± 0.447
Table 4

Average spongiosa indices

GroupnumberAverage scoreTest statisticsdfSig
54.5
Control57.38.42220.015
512.2
54.2
Hydroxyapatite5710.81820.004
512.8
53.4
β-tricalcium phosphate5811.48220.003
512.6
53.4
Nanocomposite58.99.78920.007
polycaprolactone511.7
Table 5

Statistical analysis of cortex index

Group Day153045
Control0.2 ± 0.4471 ± 0.7071.8 ± 0.447
Hydroxyapatite0.6 ± 0.5471.4 ± 0.5472.2 ± 0.836
β-tricalcium phosphate1.4 ± 0.5472 ± 0.7073.2 ± 0.836
Nanocomposite polycaprolactone1.8 ± 0.8362.8 ± 0.8363.6 ± 0.547
Table 6

Average cortex indices

GroupnumberAverage scoreTest statisticsdfSig
54
Control588.9620.011
512
55
Hydroxyapatite56.97.80820.02
512.1
54.2
β-tricalcium phosphate58.28.07620.018
511.6
54.2
Nanocomposite7.59120.022
polycaprolactone58.1
511.7
Table 7

Statistical analysis of bone marrow index

Day
Group153045
Control0.2 ± 0.4471 ± 0.7071.4 ± 0.547
Hydroxyapatite1 ± 0.7071.4 ± 0.5472.4 ± 0.547
β-tricalcium phosphate1.4 ± 0.5471.8 ± 0.8362.8 ± 0.447
Nanocomposite polycaprolactone1.6 ± 0.5472.4 ± 0.5473.4 ± 0.547
Table 8

Average bone marrow indices

GroupsnumberAverage scoresTest statisticsdfSig
54.20
Control58.807.02320.030
511
55
Hydroxyapatite56.907.73620.021
512.10
55
β-tricalcium phosphate577.28020.26
512
53.90
Nanocomposite57.7010.09220.006
polycaprolactone
512.40
Fig. 1

Microscopic view of healing area in control group on day 15. It shows abundant capillary buds (arrows) in granulation tissue (H&E, 100×)

Fig. 2

Microscopic view of healing area in tricalcium phosphate (TCP) group on day 15. It shows abundant calcified cartilage (arrow) (H&E, 100×)

Fig. 3

Microscopic view of healing area in hydroxyapatite (HA) group on day 15.It shows fibrous tissue (arrow) (H&E, 100×)

Fig. 4

Microscopic view of healing area in PCL group on day 15. It shows primary bone (arrows) formation (H&E, 100×)

Fig. 5

Microscopic view of healing area in control group on day 30. It shows abundant fibrous tissue (arrows) filling marrow space (H&E, 100×)

Fig. 6

Microscopic view of healing area in tricalcium phosphate (TCP) group on day 30. Primary bones (arrow) are being produced (H&E, 100×)

Fig. 7

Microscopic view of healing area in hydroxyapatite group on day 30. Calcified cartilage (arrow) in the mature granulation tissue (H&E, 100×)

Fig. 8

Microscopic view of healing area in PCL group on day 30. Woven bones (arrows) are being produced (H&E, 100×)

Fig. 9

Microscopic view of healing area in control group on day 45. Bone deposition within cartilage (star) at healing site shows primary (arrows) ossification (H&E, 100×)

Fig. 10

Microscopic view of healing area in tricalcium phosphate (TCP) group on day 45. Lamellar bone formation (arrows) in healing site is shown (H&E, 100×)

Fig. 11

Microscopic view of healing area in hydroxyapatite group on day 45. The defect is filled with primary bone (arrows) and well-formed marrow (star) (H&E, 100×)

Fig. 12

Microscopic view of healing area in PCL group on day 45. The defect is filled with lamellar (arrows) bone (H&E, 100×)

DOI: https://doi.org/10.2478/jvetres-2018-0055 | Journal eISSN: 2450-8608 (formerly 2300-3235)
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Language: English
Page range: 385 - 394
Submitted on: Feb 1, 2018
Accepted on: Sep 26, 2018
Published on: Oct 23, 2018
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Keywords:
rabbits,
bone healing,
nanocomposite polycaprolactone,
β-tricalcium phosphate,
hydroxyapatite
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2018 Hadi Eftekhari, Alireza Jahandideh, Ahmad Asghari, Abolfazl Akbarzadeh, Saeed Hesaraki, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 62 (2018): Issue 3 (September 2018)
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