Increased p63 expression in canine perianal gland tumours

Soo-Hyeon Kim; Byung-Joon Seung; Seung-Hee Cho; Ha-Young Lim; Hee-Myung Park; Jung-Hyang Sur

doi:10.2478/jvetres-2018-0020

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Increased p63 expression in canine perianal gland tumours

Journal of Veterinary Research

Volume 62 (2018): Issue 2 (June 2018)

By: Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Hee-Myung Park and Jung-Hyang Sur

Open Access

|Jul 2018

Figures & Tables

Histopathological classification of perianal gland tumours (200×). Perianal gland adenoma is characterised by lobules and cords separated by a layer of basaloid reserve cells (A) and perianal gland carcinoma shows disrupted lobules and disorderly proliferated tumour cells (B)

Box plot analysis of total expression score of p63 in perianal gland adenoma (A) and carcinoma (C) samples

Mean value of total score, percentage of p63 of stained cells (blue bars), and intensity levels (yellow bars) of p63 in perianal gland adenoma (A) and carcinoma (C) samples

Immunohistochemistry of p63 in canine perianal gland tumour tissues; A – p63 expression in perianal gland adenoma (200×), B – p63 expression in perianal gland adenoma (400×), C – p63 expression in perianal gland carcinoma (200×), D – p63 expression in perianal gland carcinoma (400×)

Western blotting for p63 antibody validation

Clinical data of dogs with tumours

Adenoma	Breed	Sex	Age (years)	BCS (BW)	Location	Carcinoma	Breed	Sex	Age (years)	BCS (BW)	Location
1	Pekinese	IM	12	N/ A	Perianal	1	Shih-Tzu	CM	5	N/A (5.7kg)	Perianal
2	Shih-Tzu	Unk	8	N/ A	Perianal	2	Mongrel	IM	14	4	Perianal
3	Pungsan	IM	9	N/ A (35kg)	Perianal	3	Yorkshire Terrier	IM	12	3	Perianal
4	Alaskan Malamute	IM	10	N/ A (60kg)	Perianal	4	Cocker Spaniel	SF	13	N/ A	Prepuce
5	Maltese	SF	10	N/ A (3.2kg)	Perianal	5	Schnauzer	IM	8	N/ A	Tail
6	Miniature Poodle	IM	8	N/ A (4.5kg)	Perianal	6	Shih-Tzu	CM	14	4	Perianal
7	Mongrel	IM	8	N/ A	Perianal	7	Cocker Spaniel	IM	10	3	Perianal
8	Maltese	IM	11	N/ A (3.16kg)	Perianal	8	Mongrel	CM	12	N/ A	Prepuce
9	Miniature Poodle	IM	13	4	Perianal	9	Cocker Spaniel	CM	12	N/ A (16kg)	Perianal
10	Maltese	IF	11	4	Perianal	10	Maltese	CM	Unk	3	Perianal
11	Jindo	IM	10	3	Perianal	11	Shih-Tzu	IM	12	N/ A (7kg)	Perianal
12	Unk	SF	14	N/ A	Perianal	12	Shih-Tzu	CM	12	N/A (9.7kg)	Perianal
13	Dachshund	IM	13	N/ A (6.8kg)	Perianal	13	Jindo	IM	7	3	Perianal
14	Schnauzer	SF	13	N/ A (6.9kg)	Perianal	14	Shih-Tzu	CM	10	N/ A	Perianal
15	Jindo	IM	14	N/ A (18kg)	Perianal	15	Cocker Spaniel	IF	12	N/ A (11.5kg)	Perianal
16	Siberian Husky	IM	10	N/ A (40kg)	Perianal	16	Jindo	IM	12	N/A (9.1kg)	Perianal
17	Shih-Tzu	SF	14	5	Perianal	17	Miniature Poodle	CM	11	3	Perianal
18	Schnauzer	IM	13	N/A (9.3kg)	Perianal	18	Unk	IM	15	Unk	Prepuce
19	Pekinese	IM	12	N/A (16kg)	Perianal	19	Toy Fox Terrier	SF	13	4	Perianal
20	Shih-Tzu	IM	11	N/A (6kg)	Perianal	20	Shih-Tzu	IM	13	N/ A (7.6kg)	Perianal
21	Caucasian Ovcharka	IF	12	4	Perianal	21	Maltese	IM	10	3	Perianal
22	Miniature Pinscher	IM	10	N/ A (8.3kg)	Perianal	22	Shih-Tzu	IM	15	N/ A	Perianal
23	Maltese	SF	8	N/ A	Perianal	23	Shih-Tzu	CM	12	4	Perianal
24	Siberian Husky	IM	10	N/ A (40kg)	Perianal	24	Yorkshire Terrier	CM	14	3	Perianal
25	Shih-Tzu	IM	11	N/ A (7.15kg)	Perianal	25	Mongrel	IM	10	3	Perianal
26	Mongrel	Unk	13	N/ A	Tail	26	Shih-Tzu	Unk	11	N/ A (6.8kg)	Perianal
27	Mongrel	IF	7	3	Perianal	27	Shih-Tzu	IM	12	N/ A (6.7kg)	Perianal
28	Maltese	SF	10	N/ A (3.1kg)	Perianal	28	Maltese	IM	11	N/ A (4.6kg)	Prepuce
29	Shih-Tzu	IM	9	N/ A (10kg)	Perianal	29	Mongrel	CM	13	3	Perianal
30	Mongrel	IM	10	N/ A	Tail	30	Yorkshire Terrier	IM	14	N/ A	Perianal
31	Afghan Hound	IM	9	3	Perianal	31	Yorkshire Terrier	SF	13	N/ A	Perianal
32	Dachshund	IM	10	N/ A	Unk	32	Shih-Tzu	IM	15	N/A	Perianal
										(8.9kg)
33	Beagle	IM	10	3	Perianal

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DOI: https://doi.org/10.2478/jvetres-2018-0020 | Journal eISSN: 2450-8608

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Language: English

Page range: 229 - 235

Submitted on: Dec 22, 2017

Accepted on: May 23, 2018

Published on: Jul 7, 2018

Published by: National Veterinary Research Institute in Pulawy

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

dog,

perianal gland tumour,

p63,

immunohistochemistry

Related subjects:

Life sciences,

Molecular biology,

Microbiology and virology,

Life sciences, other,

Medicine,

Veterinary medicine

© 2018 Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Hee-Myung Park, Jung-Hyang Sur, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Volume 62 (2018): Issue 2 (June 2018)

Increased p63 expression in canine perianal gland tumours

Figures & Tables

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Fig. 5

Clinical data of dogs with tumours

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