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Increased p63 expression in canine perianal gland tumours

Journal of Veterinary Research
Volume 62 (2018): Issue 2 (June 2018)
By:
Open Access
|Jul 2018

Figures & Tables

Fig. 1

Histopathological classification of perianal gland tumours (200×). Perianal gland adenoma is characterised by lobules and cords separated by a layer of basaloid reserve cells (A) and perianal gland carcinoma shows disrupted lobules and disorderly proliferated tumour cells (B)
Histopathological classification of perianal gland tumours (200×). Perianal gland adenoma is characterised by lobules and cords separated by a layer of basaloid reserve cells (A) and perianal gland carcinoma shows disrupted lobules and disorderly proliferated tumour cells (B)

Fig. 2

Box plot analysis of total expression score of p63 in perianal gland adenoma (A) and carcinoma (C) samples
Box plot analysis of total expression score of p63 in perianal gland adenoma (A) and carcinoma (C) samples

Fig. 3

Mean value of total score, percentage of p63 of stained cells (blue bars), and intensity levels (yellow bars) of p63 in perianal gland adenoma (A) and carcinoma (C) samples
Mean value of total score, percentage of p63 of stained cells (blue bars), and intensity levels (yellow bars) of p63 in perianal gland adenoma (A) and carcinoma (C) samples

Fig. 4

Immunohistochemistry of p63 in canine perianal gland tumour tissues; A – p63 expression in perianal gland adenoma (200×), B – p63 expression in perianal gland adenoma (400×), C – p63 expression in perianal gland carcinoma (200×), D – p63 expression in perianal gland carcinoma (400×)
Immunohistochemistry of p63 in canine perianal gland tumour tissues; A – p63 expression in perianal gland adenoma (200×), B – p63 expression in perianal gland adenoma (400×), C – p63 expression in perianal gland carcinoma (200×), D – p63 expression in perianal gland carcinoma (400×)

Fig. 5

Western blotting for p63 antibody validation
Western blotting for p63 antibody validation

Clinical data of dogs with tumours

AdenomaBreedSexAge (years)BCS (BW)LocationCarcinomaBreedSexAge (years)BCS (BW)Location
1PekineseIM12N/ APerianal1Shih-TzuCM5N/A (5.7kg)Perianal
2Shih-TzuUnk8N/ APerianal2MongrelIM144Perianal
3PungsanIM9N/ A (35kg)Perianal3Yorkshire TerrierIM123Perianal
4Alaskan MalamuteIM10N/ A (60kg)Perianal4Cocker SpanielSF13N/ APrepuce
5MalteseSF10N/ A (3.2kg)Perianal5SchnauzerIM8N/ ATail
6Miniature PoodleIM8N/ A (4.5kg)Perianal6Shih-TzuCM144Perianal
7MongrelIM8N/ APerianal7Cocker SpanielIM103Perianal
8MalteseIM11N/ A (3.16kg)Perianal8MongrelCM12N/ APrepuce
9Miniature PoodleIM134Perianal9Cocker SpanielCM12N/ A (16kg)Perianal
10MalteseIF114Perianal10MalteseCMUnk3Perianal
11JindoIM103Perianal11Shih-TzuIM12N/ A (7kg)Perianal
12UnkSF14N/ APerianal12Shih-TzuCM12N/A (9.7kg)Perianal
13DachshundIM13N/ A (6.8kg)Perianal13JindoIM73Perianal
14SchnauzerSF13N/ A (6.9kg)Perianal14Shih-TzuCM10N/ APerianal
15JindoIM14N/ A (18kg)Perianal15Cocker SpanielIF12N/ A (11.5kg)Perianal
16Siberian HuskyIM10N/ A (40kg)Perianal16JindoIM12N/A (9.1kg)Perianal
17Shih-TzuSF145Perianal17Miniature PoodleCM113Perianal
18SchnauzerIM13N/A (9.3kg)Perianal18UnkIM15UnkPrepuce
19PekineseIM12N/A (16kg)Perianal19Toy Fox TerrierSF134Perianal
20Shih-TzuIM11N/A (6kg)Perianal20Shih-TzuIM13N/ A (7.6kg)Perianal
21Caucasian OvcharkaIF124Perianal21MalteseIM103Perianal
22Miniature PinscherIM10N/ A (8.3kg)Perianal22Shih-TzuIM15N/ APerianal
23MalteseSF8N/ APerianal23Shih-TzuCM124Perianal
24Siberian HuskyIM10N/ A (40kg)Perianal24Yorkshire TerrierCM143Perianal
25Shih-TzuIM11N/ A (7.15kg)Perianal25MongrelIM103Perianal
26MongrelUnk13N/ ATail26Shih-TzuUnk11N/ A (6.8kg)Perianal
27MongrelIF73Perianal27Shih-TzuIM12N/ A (6.7kg)Perianal
28MalteseSF10N/ A (3.1kg)Perianal28MalteseIM11N/ A (4.6kg)Prepuce
29Shih-TzuIM9N/ A (10kg)Perianal29MongrelCM133Perianal
30MongrelIM10N/ ATail30Yorkshire TerrierIM14N/ APerianal
31Afghan HoundIM93Perianal31Yorkshire TerrierSF13N/ APerianal
32DachshundIM10N/ AUnk32Shih-TzuIM15N/APerianal
(8.9kg)
33BeagleIM103Perianal
DOI: https://doi.org/10.2478/jvetres-2018-0020 | Journal eISSN: 2450-8608
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Language: English
Page range: 229 - 235
Submitted on: Dec 22, 2017
Accepted on: May 23, 2018
Published on: Jul 7, 2018
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
dog,
perianal gland tumour,
p63,
immunohistochemistry
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2018 Soo-Hyeon Kim, Byung-Joon Seung, Seung-Hee Cho, Ha-Young Lim, Hee-Myung Park, Jung-Hyang Sur, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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