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Xylazine regulates the release of glycine and aspartic acid in rat brain Cover

Xylazine regulates the release of glycine and aspartic acid in rat brain

Journal of Veterinary Research
Volume 62 (2018): Issue 1 (March 2018)
By: Yi-Ming Zhang,  Dong-Xu Yu,  Bai-Shuang Yin,  Xin-Ran Li,  Li-Na Li,  Ya-Nan Li,  Yu-Xin Wang,  Yu Chen,  Wen-Han Liu and  Li Gao  
Open Access
|Mar 2018

Figures & Tables

Fig. 1

The effect of low-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period ( group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of low-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period ( group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 2

The effect of low-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of low-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 3

The effect of high-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of high-dose xylazine anaesthesia on Gly neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period (group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 4

The effect of high-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period ( group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01
The effect of high-dose xylazine anaesthesia on Asp neurotransmitters in rat brain. C – control group, I – induction period, A – anaesthesia period, R1 – recovery period (group R1), R2 – recovery period ( group R2), R3 – recovery period (group R3). ∗P < 0.05; ∗∗P < 0.01

Fig. 5

Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Gly. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Gly. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value

Fig. 6

Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Asp. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
Effects of different concentrations of xylazine on neurons secreting the neurotransmitter Asp. At 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min xylazine was allowed to act on the neurons. (A) 15 μg/mL xylazine, (B) 25 μg/mL xylazine, (C) 35 μg/mL xylazine, (D) 45 μg/mL xylazine. ∗P < 0.05; ∗∗P < 0.01 versus control, #P < 0.05; ##P < 0.01 versus the minimum value
DOI: https://doi.org/10.2478/jvetres-2018-0017 | Journal eISSN: 2450-8608
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Language: English
Page range: 121 - 128
Submitted on: Sep 15, 2017
Accepted on: Feb 14, 2018
Published on: Mar 30, 2018
Published by: National Veterinary Research Institute in Pulawy
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
rats,
brain,
xylazine,
glycine,
aspartic acid
Related subjects:
Life sciences,
Molecular biology,
Microbiology and virology,
Life sciences, other,
Medicine,
Veterinary medicine

© 2018 Yi-Ming Zhang, Dong-Xu Yu, Bai-Shuang Yin, Xin-Ran Li, Li-Na Li, Ya-Nan Li, Yu-Xin Wang, Yu Chen, Wen-Han Liu, Li Gao, published by National Veterinary Research Institute in Pulawy
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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