Figure 1.
Figure 2.
Summary of article selection results
| No. | Author, year | Design | Samples | Intervention | Induction | Results |
|---|---|---|---|---|---|---|
| 1. | Durankus et al., 2020 | Experimental | 48 male Sprague-Dawley rats | 200 mg/kg and 400 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease induction | Pentylenetetrazole 35 mg/kg intraperitoneally | Reduced spike percentage in EEG, Racine Convulsion Score and low first myoclonic jerk |
| 2. | Peng et al., 2019 | Experimental | 60 male Sprague-Dawley rats | 30 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease induction | Pentylenetetrazole 35 mg/kg intraperitoneally | Reduced, number, grade, latency, shortened duration of seizures and number of small amplitude spikes and spine slow waves in EEG |
| 3. | Liu et al., 2020 | Experimental | 64 male Sprague-Dawley rats | 30 mg/kg ibuprofen injection intraperitoneally 30 minutes before disease nduction | Pentylenetetrazole 35 mg/kg intraperitoneally | Reduced frequency, latency and duration of seizures |