Have a personal or library account? Click to login
Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study Cover

Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study

Open Access
|Nov 2025

References

  1. Cholewa JM, Dardevet D, Lima-soares F, de Araújo Pessôa K, Oliveira PH, Dos Santos Pinho JR, et al. Dietary proteins and amino acids in the control of the muscle mass during immobilization and aging: role of the MPS response. Amino Acids. 2017 May;49(5):811–20. https://doi.org/10.1007/s00726-017-2390-9
  2. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul 1;39(4):412–23. https://doi.org/10.1093/ageing/afq034
  3. Marzetti E, Calvani R, Coelho-Júnior HJ, Landi F, Picca A. Mitochondrial Quantity and Quality in Age-Related Sarcopenia. Int J Mol Sci. 2024 Jan;25(4):2052. https://doi.org/10.3390/ijms25042052
  4. Huang DD, Wang SL, Zhuang CL, Zheng BS, Lu JX, Chen FF, et al. Sarcopenia, as defined by low muscle mass, strength and physical performance, predicts complications after surgery for colorectal cancer. Colorectal Dis. 2015;17(11):O256–64. https://doi.org/10.1111/codi.13067
  5. Schaap LA, van Schoor NM, Lips P, Visser M. Associations of Sarcopenia Definitions, and Their Components, With the Incidence of Recurrent Falling and Fractures: The Longitudinal Aging Study Amsterdam. J Gerontol Ser A. 2018 Aug 10;73(9):1199–204. https://doi.org/10.1093/gerona/glx245
  6. Rubbieri G, Mossello E, Di Bari M. Techniques for the diagnosis of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):181–4. https://doi.org/10.11138/ccmbm/2014.11.3.181
  7. Castizo-Olier J, Irurtia A, Jemni M, Carrasco-Marginet M, Fernández-García R, Rodríguez FA. Bioelectrical impedance vector analysis (BIVA) in sport and exercise: Systematic review and future perspectives. PLOS ONE. 2018 Jun 7;13(6):e0197957. https://doi.org/10.1371/journal.pone.0197957
  8. Gudivaka R, Schoeller DA, Kushner RF, Bolt MJ. Single- and multifrequency models for bioelectrical impedance analysis of body water compartments. J Appl Physiol Bethesda Md 1985. 1999 Sep;87(3):1087–96. https://doi.org/10.1152/jappl.1999.87.3.1087
  9. da Silva BR, Orsso CE, Gonzalez MC, Sicchieri JMF, Mialich MS, Jordao AA, et al. Phase angle and cellular health: inflammation and oxidative damage. Rev Endocr Metab Disord. 2023;24(3):543–62. https://doi.org/10.1007/s11154-022-09775-0
  10. Cancello R, Brunani A, Brenna E, Soranna D, Bertoli S, Zambon A, et al. Phase angle (PhA) in overweight and obesity: evidence of applicability from diagnosis to weight changes in obesity treatment. Rev Endocr Metab Disord. 2023;24(3):451–64. https://doi.org/10.1007/s11154-022-09774-1
  11. Rees AE, Ward LC, Cornish BH, Thomas BJ. Sensitivity of multiple frequency bioelectrical impedance analysis to changes in ion status. Physiol Meas. 1999 Nov 1;20(4):349–62. https://doi.org/10.1088/0967-3334/20/4/302
  12. Barbosa-Silva MCG, Barros AJ, Wang J, Heymsfield SB, Pierson RN. Bioelectrical impedance analysis: population reference values for phase angle by age and sex2. Am J Clin Nutr. 2005 Jul 1;82(1):49–52. https://doi.org/10.1093/ajcn/82.1.49
  13. Norman K, Stobäus N, Pirlich M, Bosy-Westphal A. Bioelectrical phase angle and impedance vector analysis - Clinical relevance and applicability of impedance parameters. Clin Nutr. 2012 Dec 1;31(6):854–61. https://doi.org/10.1016/j.clnu.2012.05.008
  14. Xia X xin, Li C xiang, Xue X xin, Chen Y jun, He F, Guo H rong. Association between phase angle and all-cause mortality in adults aged 18–49 years: NHANES 1999–2004. Sci Rep. 2025 Jan 22;15(1):2785. https://doi.org/10.1038/s41598-025-86825-y
  15. Bosy-Westphal A, Danielzik S, Dörhöfer RP, Later W, Wiese S, Müller MJ. Phase Angle From Bioelectrical Impedance Analysis: Population Reference Values by Age, Sex, and Body Mass Index. J Parenter Enter Nutr. 2006;30(4):309–16. https://doi.org/10.1177/0148607106030004309
  16. Di Vincenzo O, Marra M, Di Gregorio A, Pasanisi F, Scalfi L. Bioelectrical impedance analysis (BIA) -derived phase angle in sarcopenia: A systematic review. Clin Nutr Edinb Scotl. 2021 May;40(5):3052–61. https://doi.org/10.1016/j.clnu.2020.10.048
  17. Blue MNM, Tinsley GM, Hirsch KR, Ryan ED, Ng BK, Smith-Ryan AE. Validity of total body water measured by multi-frequency bioelectrical impedance devices in a multi-ethnic sample. Clin Nutr ESPEN. 2023 Apr;54:187–93. https://doi.org/10.1016/j.clnesp.2023.01.026
  18. Yajima T, Yajima K. Ratio of extracellular water to intracellular water and simplified creatinine index as predictors of all-cause mortality for patients receiving hemodialysis. PloS One. 2023;18(3):e0282864. https://doi.org/10.1371/journal.pone.0282864
  19. Serra-Prat M, Lorenzo I, Palomera E, Ramírez S, Yébenes JC. Total Body Water and Intracellular Water Relationships with Muscle Strength, Frailty and Functional Performance in an Elderly Population. A Cross-Sectional Study. J Nutr Health Aging. 2019 Jan 1;23(1):96–101. https://doi.org/10.1007/s12603-018-1129-y
  20. Silva AM, Wang J, Pierson RN, Wang Z, Heymsfield SB, Sardinha LB, et al. Extracellular water: greater expansion with age in African Americans. J Appl Physiol. 2005 Jul;99(1):261–7. https://doi.org/10.1152/japplphysiol.01317.2004
  21. Valensi P, L'Hermite F, Behar A, Sandre-Banon D, Cohen-Boulakia F, Attali JR. Extra cellular water and increase in capillary permeability to albumin in overweight women with swelling syndrome. Int J Obes. 2000 Jan;24(1):126–30. https://doi.org/10.1038/sj.ijo.0801096
  22. Ziegenfuss T, Lowery L, Lemon P. Acute fluid volume changes in men during three days of creatine supplementation. J Exerc Physiol. 1998 Oct;1(3).
  23. Tipton KD, Gurkin BE, Matin S, Wolfe RR. Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem. 1999 Feb 1;10(2):89–95. https://doi.org/10.1016/S0955-2863(98)00087-4
  24. Di Vincenzo O, Marra M, Scalfi L. Bioelectrical impedance phase angle in sport: a systematic review. J Int Soc Sports Nutr. 2019 Nov 6;16(1):49. https://doi.org/10.1186/s12970-019-0319-2
  25. Lukaski HC, Garcia-Almeida JM. Phase angle in applications of bioimpedance in health and disease. Rev Endocr Metab Disord. 2023 Jun 1;24(3):367–70. https://doi.org/10.1007/s11154-023-09799-0
  26. Hirano Y, Yamada Y, Matsui Y, Ota S, Arai H. Lower limb muscle quality and phase angle contribute to the reduced walking speed among older adults. Geriatr Gerontol Int. 2022;22(8):603–9. https://doi.org/10.1111/ggi.14423
  27. Buffa R, Floris G, Marini E. Migration of the bioelectrical impedance vector in healthy elderly subjects. Nutr Burbank Los Angel Cty Calif. 2003;19(11-12):917–21. https://doi.org/10.1016/S0899-9007(03)00180-1
  28. Genton L, Norman K, Spoerri A, Pichard C, Karsegard V, Herrmann FR, et al. Bioimpedance-derived phase angle and mortality among older people. Innov Aging. 2017 Jun 30;1(Suppl 1):552. https://doi.org/10.1093/geroni/igx004.1947
  29. Slinde F, Rossander-Hulthén L. Bioelectrical impedance: effect of 3 identical meals on diurnal impedance variation and calculation of body composition12. Am J Clin Nutr. 2001 Oct 1;74(4):474–8. https://doi.org/10.1093/ajcn/74.4.474
  30. Fogelholm M, Sievänen H, Kukkonen-Harjula K, Oja P, Vuori I. Effects of Meal and Its Electrolytes on Bioelectrical Impedance. In: Ellis KJ, Eastman JD, editors. Human Body Composition: In Vivo Methods, Models, and Assessment [Internet]. Boston, MA: Springer US; 1993. https://doi.org/10.1007/978-1-4899-1268-8_75
  31. Deurenberg P, Weststrate JA, Paymans I, van der Kooy K. Factors affecting bioelectrical impedance measurements in humans. Eur J Clin Nutr. 1988 Dec 1;42(12):1017–22.
  32. Groen BBL, Horstman AM, Hamer HM, Haan M de, Kranenburg J van, Bierau J, et al. Post-Prandial Protein Handling: You Are What You Just Ate. PLOS ONE. 2015 Nov 10;10(11):e0141582. https://doi.org/10.1371/journal.pone.0141582
  33. Alyass A, Almgren P, Akerlund M, Dushoff J, Isomaa B, Nilsson P, et al. Modelling of OGTT curve identifies 1 h plasma glucose level as a strong predictor of incident type 2 diabetes: results from two prospective cohorts. Diabetologia. 2015 Jan 1;58(1):87–97. https://doi.org/10.1007/s00125-014-3390-x
  34. Park I, Lee JH, Jang DH, Kim J, Hwang BR, Kim S, et al. Assessment of body water distribution in patients with sepsis during fluid resuscitation using multi-frequency direct segmental bioelectrical impedance analysis. Clin Nutr. 2020 Jun 1;39(6):1826–31. https://doi.org/10.1016/j.clnu.2019.07.022
  35. Hioka A, Akazawa N, Okawa N, Nagahiro S. Influence of aging on extracellular water-to-total body water ratio in community-dwelling females. Clin Nutr ESPEN. 2024 Apr 1;60:73–8. https://doi.org/10.1016/j.clnesp.2024.01.007
  36. Hirsch KR, Blue MNM, Smith-Ryan AE. Sensitivity of Raw Bioimpedance Values to Acute Feeding in Healthy Young Adults: Potential Utility for Application. Meas Phys Educ Exerc Sci. 2023 Jul 3;27(3):283–91. https://doi.org/10.1080/1091367X.2023.2172682
  37. Tinsley GM, Stratton MT, Harty PS, Williams AD, White SJ, Rodriguez C, et al. Influence of acute water ingestion and prolonged standing on raw bioimpedance and subsequent body fluid and composition estimates. J Electr Bioimpedance. 2022 Jan 1;13(1):10–20. https://doi.org/10.2478/joeb-2022-0003
  38. Sinning WE, Morgan AL. The Effects of Body Position on Bioimpedance Spectroscopy. In: Ellis KJ, Eastman JD, editors. Human Body Composition: In Vivo Methods, Models, and Assessment [Internet]. Boston, MA: Springer US; 1993 [cited 2025 Nov 3]. p. 377–80. https://doi.org/10.1007/978-1-4899-1268-8_88
  39. Sanchez B, Martinsen OG, Freeborn TJ, Furse CM. Electrical impedance myography: A critical review and outlook. Clin Neurophysiol. 2021 Feb 1;132(2):338–44. https://doi.org/10.1016/j.clinph.2020.11.014
Language: English
Page range: 119 - 128
Submitted on: Sep 11, 2025
Published on: Nov 28, 2025
Published by: University of Oslo
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2025 Callie L. Unrein, David D. Church, Arny A. Ferrando, Robert R. Wolfe, Katie R. Hirsch, published by University of Oslo
This work is licensed under the Creative Commons Attribution 4.0 License.