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Biosensor of inflammation biomarkers based on electrical bioimpedance analysis on immobilized DNA without chemical modification

Journal of Electrical Bioimpedance
Volume 11 (2020): Issue 1 (January 2020)
By:
Open Access
|Jun 2020

Figures & Tables

Fig. 1

Components of the cDNA biosensor system.
Components of the cDNA biosensor system.

Fig. 2

Diagram of functionalized gold surface quartz crystal and representation of the cDNA anchorage and hybridization.
Diagram of functionalized gold surface quartz crystal and representation of the cDNA anchorage and hybridization.

Fig. 3

Nyquiste plot EBiS spectra for the three genes studied (NLRP3, IL-1B and Caspase 1) as well as control (vehicle) and negative control (non-specific gene) conditions.
Nyquiste plot EBiS spectra for the three genes studied (NLRP3, IL-1B and Caspase 1) as well as control (vehicle) and negative control (non-specific gene) conditions.

Fig. 4

Relative integrated EBiS vs relative qPCR expression of the genes NLRP3, IL-1β, and Casp-1. One-way ANOVA test *p<0.01, **p<0.05.
Relative integrated EBiS vs relative qPCR expression of the genes NLRP3, IL-1β, and Casp-1. One-way ANOVA test *p<0.01, **p<0.05.

Fig. 5

Numerical modelling of a simple DNA molecule anchoring on an electrode surface. Frequency response of the RC equivalent circuit calculated by LTspice IV.
Numerical modelling of a simple DNA molecule anchoring on an electrode surface. Frequency response of the RC equivalent circuit calculated by LTspice IV.
DOI: https://doi.org/10.2478/joeb-2020-0006 | Journal eISSN: 1891-5469
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Language: English
Page range: 31 - 37
Submitted on: Mar 10, 2020
Published on: Jun 25, 2020
Published by: University of Oslo
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
Biosensor,
bioimpedance,
gene,
DNA
Related subjects:
Engineering,
Bioengineering and biomedical engineering,
Biomedical electronics,
Life sciences,
Biophysics,
Medicine,
Biomedical engineering,
Physics,
Spectroscopy and metrology

© 2020 Modesto Gómez-López, Ángel Miliar-García, Nadia Mabel Pérez-Vielma, Eleazar Lara-Padilla, César Antonio González-Díaz, published by University of Oslo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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