Have a personal or library account? Click to login
The Benefit of Benralizumab Monoclonal Antibody Treatment for Severe Eosinophilic Asthma in a Case Series (Pulmonology Clinic Târgu Mureș, Romania) Cover

The Benefit of Benralizumab Monoclonal Antibody Treatment for Severe Eosinophilic Asthma in a Case Series (Pulmonology Clinic Târgu Mureș, Romania)

Open Access
|Oct 2021

References

  1. 1. Kommaraju K, Latifi M. Outpatient management of asthma in adults: A snapshot of the 2020 GINA report. Cleve Clin J Med. 2021;88:377-380.10.3949/ccjm.88a.20167
  2. 2. Wang E, Wechsler ME, Tran TN, et al. Characterization of Severe Asthma Worldwide: Data From the International Severe Asthma Registry. Chest. 2020;157:790-804.10.1016/j.chest.2019.10.053
  3. 3. Burney P, Jarvis D, Perez-Padilla R. The global burden of chronic respiratory disease in adults. Int J Tuberc Lung Dis. 2015;19:10-20.10.5588/ijtld.14.0446
  4. 4. Menzies-Gow A, Corren J, Bel EH, et al. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019;5:00009-2019.10.1183/23120541.00009-2019
  5. 5. Park HS, Kim MK, Imai N, et al. Asian Benralizumab Study Group. A Phase 2a Study of Benralizumab for Patients with Eosinophilic Asthma in South Korea and Japan. Int Arch Allergy Immunol. 2016;169:135-145.10.1159/000444799
  6. 6. Laviolette M, Gossage DL, Gauvreau G, et al. Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia. J Allergy Clin Immunol. 2013;132:1086-1096.10.1016/j.jaci.2013.05.020
  7. 7. Bagnasco D, Heffler E, Testino E, Passalacqua G, Canonica GW. Pharmacokinetics and pharmacodynamics of monoclonal antibodies for asthma treatment. Expert Opin Drug Metab Toxicol. 2019;15:113-120.10.1080/17425255.2019.1568409
  8. 8. Goldman M, Hirsch I, Zangrilli JG, Newbold P, Xu X. The association between blood eosinophil count and benralizumab efficacy for patients with severe, uncontrolled asthma: subanalyses of the Phase III SIROCCO and CALIMA studies. Curr Med Res Opin. 2017;33:1605-1613.10.1080/03007995.2017.1347091
  9. 9. O’Quinn S, Xu X, Hirsch I. Daily patient-reported health status assessment improvements with benralizumab for patients with severe, uncontrolled eosinophilic asthma. J Asthma Allergy. 2019;12:21-33.10.2147/JAA.S190221
  10. 10. Dunican EM, Fahy JV. Asthma and corticosteroids: time for a more precise approach to treatment. Eur Respir J. 2017;49:1701167.10.1183/13993003.01167-2017
  11. 11. Pazdrak K, Moon Y, Straub C, Stafford S, Kurosky A. Eosinophil resistance to glucocorticoid-induced apoptosis is mediated by the transcription factor NFIL3. Apoptosis. 2016;21:421-431.10.1007/s10495-016-1226-5
  12. 12. Molfino NA, Gossage D, Kolbeck R, Parker JM, Geba GP. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy. 2012;42:712-737.10.1111/j.1365-2222.2011.03854.x
  13. 13. Varricchi G, Bagnasco D, Borriello F, Heffler E, Canonica GW. Interleukin-5 pathway inhibition in the treatment of eosinophilic respiratory disorders: Evidence and unmet needs. Curr Opin Allergy Clin Immunol. 2016;16:186-200.10.1097/ACI.0000000000000251
  14. 14. Pham TH, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers by benralizumab in patients with asthma. Respir Med. 2016;111:21-29.10.1016/j.rmed.2016.01.003
  15. 15. O’Quinn S, Xu X, Hirsch I. Daily patient-reported health status assessment improvements with benralizumab for patients with severe, uncontrolled eosinophilic asthma. J Asthma Allergy. 2019;12:21-33.10.2147/JAA.S190221
  16. 16. van Dijk BCP, Svedsater H, Heddini A, Nelsen L, Balradj JS, Alleman C. Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review. BMC Pulm Med. 2020;20:79.10.1186/s12890-020-1090-5
DOI: https://doi.org/10.2478/jim-2021-0030 | Journal eISSN: 2501-8132 | Journal ISSN: 2501-5974
Language: English
Page range: 157 - 161
Submitted on: Sep 4, 2021
Accepted on: Sep 11, 2021
Published on: Oct 14, 2021
Published by: Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Nimród László, Hédy Katalin Sárközy, Cristina Alexandra Man, Edith Simona Ianoși, Botond Mátyás, Bianca Emilia Ciurba, Corina Mărginean, Gabriela Jimborean, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.