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Unresponsive Severe Aplastic Anemia in a Young Patient: Case Report and Short Review of the Literature Cover

Unresponsive Severe Aplastic Anemia in a Young Patient: Case Report and Short Review of the Literature

Open Access
|Jul 2021

References

  1. 1. Dolberg OJ, Levy Y. Idiopathic aplastic anemia: Diagnosis and classification. Autoimmun Rev. 2014;13:569-573.10.1016/j.autrev.2014.01.014
  2. 2. Young NS. Acquired aplastic anemia. Ann Intern Med. 2020;136:534-546.10.7326/0003-4819-136-7-200204020-00011
  3. 3. Savașan S. Acquired aplastic anemia: what have we learned and what is the horizon? Pediatr Clin North Am. 2018;65:597-606.
  4. 4. Ahmed P, Chaudhry Q, Satti TM, et al. Epidemiology of aplastic anemia: a study of 1324 cases. Hematology. 2020;25:48-54.10.1080/16078454.2019.1711344
  5. 5. Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood. 2006;108:2509-2519.10.1182/blood-2006-03-010777
  6. 6. Schoentler ML, Nathan DG. The pathophysiology of acquired aplastic anemia: current concepts revisited. Hematol Oncol Clin North Am. 2018;32:581-594.10.1016/j.hoc.2018.03.001
  7. 7. Camitta BM. Criteria for severe aplastic anaemia. Lancet. 1988;1:303-304.10.1016/S0140-6736(88)90388-1
  8. 8. DeZern AE, Brodsky RA. Clinical management of aplastic anemia. Expert Rev Hematol. 2012;4:221-230.
  9. 9. Killick SB, Bown N, Cavenagh J, et al. Guidelines for the diagnosis and management of adult aplastic anaemia. Br J Haematol. 2016:172:187-207.10.1111/bjh.1385326568159
  10. 10. Scheinberg P. Recent advances and long-term results of medical treatment of acquired aplastic anemia: are pacients cured? Hematol Oncol Clin North Am. 2018;32:609-618.
  11. 11. Hochsmann B, Moicean A, Risitano A, Ljungman P, Schrezenmeier H. Supportive care in severe and very severe aplastic anemia. Bone Marrow Transplant. 2013;48:168-173.10.1038/bmt.2012.22023208312
  12. 12. Scheinberg P, Young NS. How I treat acquired aplastic anemia. Adv Hematol. 2012;120:1185-1196.10.1182/blood-2011-12-274019341871522517900
  13. 13. Bacigalupo A. How I treat acquired aplastic anemia. Blood. 2017;129:1428-1436.10.1182/blood-2016-08-69348128096088
  14. 14. Young NS. Aplastic anemia. N Engl J Med. 2018;379:1643-1656.10.1056/NEJMra1413485
  15. 15. Camitta BM, Rappeport JM, Parkman R, Nathan DG. Selection of patients for bone marrow transplantation in severe aplastic anemia. Blood. 1973;45:355-363.10.1182/blood.V45.3.355.355
  16. 16. Marsh JCW, Ball SE, Cavenagh J, et al. Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol. 2009;147:43-70.10.1111/j.1365-2141.2009.07842.x
  17. 17. Passweg JR, Tichelli A. Immunosuppressive treatment for aplastic anemia: are we hitting the ceiling? Haematologica. 2009;94:310-312.
  18. 18. Frickhofen N, Rosenfeld SJ. Immunosuppressive treatment of aplastic anemia with antithymocyte globulin and cyclosporine. Semin Hematol. 2000;37:56-68.10.1016/S0037-1963(00)90030-1
  19. 19. Rosenfeld S, Follman D, Nunez O, Young NS. Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. JAMA. 2003;289:1130-1135.10.1001/jama.289.9.113012622583
  20. 20. Rosenfeld SJ, Kimball J, Vining D, Young NS. Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia. Blood. 1995;85:3058-3065.10.1182/blood.V85.11.3058.bloodjournal85113058
  21. 21. Marsh J, Schrezenmeier H, Marin P, et al. Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party. Blood. 1999;93:2191-2195.10.1182/blood.V93.7.2191
  22. 22. Scheinberg P, Nunez O, Young NS. Retreatment with rabbit anti-thymocyte globulin and cyclosporin for patients with relapsed or refractory severe aplastic anaemia. Br J Haematol. 2006;11:622-627.10.1111/j.1365-2141.2006.06098.x16704436
  23. 23. Olnes MJ, Scheinberg P, Calvo KR, et al. Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med. 2012;367:11-19.10.1056/NEJMoa1200931342273722762314
  24. 24. Desmond R, Townsley DM, Dumitriu B, et al. Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood. 2014;123:1818-1825.10.1182/blood-2013-10-534743396216124345753
  25. 25. Winkler T, Cooper JN, Townsley DM, et al. Eltrombopag for refractory sever aplastic anemia: dosing, regiments, long-term follow-up, clonal evolution and somatic mutation profiling. Blood. 2017;130:777.10.1182/blood.V130.Suppl_1.777.777
  26. 26. Townsley DM, Scheinberg P, Winkler T, et al. Eltrombopag added to standard immunosuppression for aplastic anemia. N Engl J Med. 2017;376:1540-1550.10.1056/NEJMoa1613878554829628423296
  27. 27. Scheinberg P. Activity of eltrombopag in severe aplastic anemia. Hematology Am Soc Hematol Educ Program. 2018;1:450-456.10.1182/asheducation-2018.1.450624597530504345
  28. 28. Rodgers GM, Gilreath JA. Eltrombopag as initial monotherapy for severe aplastic anemia – a case report. Ann Hematol. 2018;97:1517-1518.10.1007/s00277-018-3303-z29560523
  29. 29. National Library of Medicine (U.S.) (2014 March – 2020 December). hATG+CsA vs hATG+CsA+Eltrombopag for SAA (RACE). Identifier NCT02099747. https://www.clinicaltrials.gov/ct2/show/results/NCT02099747.
DOI: https://doi.org/10.2478/jim-2021-0013 | Journal eISSN: 2501-8132 | Journal ISSN: 2501-5974
Language: English
Page range: 116 - 119
Submitted on: Feb 26, 2021
Accepted on: Mar 24, 2021
Published on: Jul 17, 2021
Published by: Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 Oana Viola Bădulescu, Diana Popescu, Minerva Codruța Bădescu, Nicoleta Dima, Ana-Roxana Gănceanu-Rusu, Ciprian Rezuș, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.