Have a personal or library account? Click to login
A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update Cover

A Genomic Approach to Characterize the Vulnerable Patient – a Clinical Update

Open Access
|Nov 2019

References

  1. 1. Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. The Lancet. 2017;389:197-210.10.1016/S0140-6736(16)30677-8
  2. 2. Hartley A, Marshall DC, Salciccioli JD, Sikkel MB, Maruthappu M, Shalhoub J. Trends in Mortality from Ischemic Heart Disease and Cerebrovascular Disease in Europe: 1980 to 2009. Circulation. 2016;133:1916-1926.10.1161/CIRCULATIONAHA.115.018931
  3. 3. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241.10.1038/35025203
  4. 4. Ross R. Atherosclerosis – An Inflammatory Disease. N Engl J Med. 1999;340:115-126.10.1056/NEJM199901143400207
  5. 5. Libby P, Theroux P. Pathophysiology of Coronary Artery Disease. Circulation. 2005;111:3481-3488.10.1161/CIRCULATIONAHA.105.537878
  6. 6. Libby P, Ridker PM, Maseri A. Inflammation and Atherosclerosis. Circulation. 2002;105:1135-1143.10.1161/hc0902.104353
  7. 7. Conti P, Shaik-Dasthagirisaeb Y. Atherosclerosis: a chronic inflammatory disease mediated by mast cells. Cent Eur J Immunol. 2015;3:380-386.10.5114/ceji.2015.54603
  8. 8. Hansson GK. Inflammation, Atherosclerosis, and Coronary Artery Disease. N Engl J Med. 2005;352:1685-1695.10.1056/NEJMra043430
  9. 9. Kuller L, Borthani N, Furberg C, et al. Prevalence of Subclinical Atherosclerosis and Cardiovascular Disease and Association with Risk Factors in the Cardiovascular Health Study. Am J Epidemiol. 1994;139:1164-1179.10.1093/oxfordjournals.aje.a116963
  10. 10. Gisterå A, Hansson GK. The immunology of atherosclerosis. Nat Rev Nephrol. 2017;13:368-380.10.1038/nrneph.2017.51
  11. 11. Marenberg ME, Risch N, Berkman LF, Floderus B, de Faire U. Genetic Susceptibility to Death from Coronary Heart Disease in a Study of Twins. N Engl J Med. 1994;330:1041-1046.10.1056/NEJM199404143301503
  12. 12. Zdravkovic S, Wienke A, Pedersen NL, Marenberg ME, Yashin AI, De Faire U. Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins. J Intern Med. 2002;252:247-254.10.1046/j.1365-2796.2002.01029.x
  13. 13. Musunuru K, Kathiresan S. Genetics of Coronary Artery Disease. Annu Rev Genomics Hum Genet. 2010;11:91-108.10.1146/annurev-genom-082509-141637
  14. 14. The International HapMap Consortium. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449:851-861.10.1038/nature06258
  15. 15. Green ED, Watson JD, Collins FS. Human Genome Project: Twenty-five years of big biology. Nature. 2015;526:29-31.10.1038/526029a
  16. 16. Helin K, Dhanak D. Chromatin proteins and modifications as drug targets. Nature. 2013;502:480-488.10.1038/nature12751
  17. 17. Haldar SM, McKinsey TA. BET-ting on chromatin-based therapeutics for heart failure. J Mol Cell Cardiol. 2014;74:98-102.10.1016/j.yjmcc.2014.05.002
  18. 18. Ashley EA, Butte AJ, Wheeler MT, et al. Clinical assessment incorporating a personal genome. The Lancet. 2010;375:1525-1535.10.1016/S0140-6736(10)60452-7
  19. 19. Zeller T, Blankenberg S. Blood-Based Gene Expression Tests: Promises and Limitations. Circ Cardiovasc Genet. 2013;6:139-140.10.1161/CIRCGENETICS.113.000149
  20. 20. Perrino C, Barabási AL, Condorelli G, et al. Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2017;113:725-736.10.1093/cvr/cvx070
  21. 21. Pedrotty DM, Morley MP, Cappola TP. Transcriptomic Biomarkers of Cardiovascular Disease. Prog Cardiovasc Dis. 2012;55:64-69.10.1016/j.pcad.2012.06.003
  22. 22. Wang L. Mutation of MEF2A in an Inherited Disorder with Features of Coronary Artery Disease. Science. 2003;302:1578-1581.10.1126/science.1088477
  23. 23. Weng L, Kavaslar N, Ustaszewska A, et al. Lack of MEF2A mutations in coronary artery disease. J Clin Invest. 2005;115:1016-1020.10.1172/JCI24186
  24. 24. Xu DL, Tian HL, Cai WL, et al. Novel 6-bp deletion in MEF2A linked to premature coronary artery disease in a large Chinese family. Mol Med Rep. 2016;14:649-654.10.3892/mmr.2016.5297
  25. 25. Rosenberg S. Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients. Ann Intern Med. 2010;153:425.10.7326/0003-4819-153-7-201010050-00005
  26. 26. Small EM, Frost RJA, Olson EN. MicroRNAs Add a New Dimension to Cardiovascular Disease. Circulation. 2010;121:1022-1032.10.1161/CIRCULATIONAHA.109.889048
  27. 27. Varga ZV, Zvara Á, Faragó N, et al. MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic preand postconditioning: protectomiRs. Am J Physiol-Heart Circ Physiol. 2014;307:H216-H227.10.1152/ajpheart.00812.2013
  28. 28. Eulalio A, Mano M, Ferro MD, et al. Functional screening identifies miRNAs inducing cardiac regeneration. Nature. 2012;492:376-381.10.1038/nature11739
  29. 29. De Windt LJ, Thum T. State-of-the-art on non-coding RNA bioinformatics, diagnostics and therapeutics in cardiovascular diseases. J Mol Cell Cardiol. 2015;89:1-2.10.1016/j.yjmcc.2015.11.021
  30. 30. Greco CM, Condorelli G. Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure. Nat Rev Cardiol. 2015;12:488-497.10.1038/nrcardio.2015.71
  31. 31. Ferdinandy P, Hausenloy DJ, Heusch G, Baxter GF, Schulz R. Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning. Pharmacol Rev. 2014;66:1142-1174.10.1124/pr.113.008300
  32. 32. Gidlöf O, Johnstone AL, Bader K, et al. Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation. J Am Heart Assoc. 2016;5.10.1161/JAHA.116.004076
  33. 33. Fernandes M, Patel A, Husi H. C/VDdb: A multi-omics expression profiling database for a knowledge-driven approach in cardiovascular disease (CVD). PLoS One. 2018;13:e0207371.10.1371/journal.pone.0207371
  34. 34. Csont T, Murlasits Z, Ménesi D, et al. Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance. J Cardiovasc Pharmacol. 2015;65:485-493.10.1097/FJC.0000000000000218
  35. 35. Kato N, Liang Y-Q, Ochiai Y, Jesmin S. Systemic evaluation of gene expression changes in major target organs induced by atorvastatin. Eur J Pharmacol. 2008;584:376-389.10.1016/j.ejphar.2008.01.043
DOI: https://doi.org/10.2478/jim-2019-0023 | Journal eISSN: 2501-8132 | Journal ISSN: 2501-5974
Language: English
Page range: 141 - 144
Submitted on: Jul 29, 2019
|
Accepted on: Sep 5, 2019
|
Published on: Nov 12, 2019
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2019 Evelin Szabó, Zsolt Parajkó, Diana Opincariu, Monica Chițu, Nóra Raț, Imre Benedek, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.