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Occult hepatitis B virus infection in people with haemophilia in South Africa

The Journal of Haemophilia Practice
Volume 12 (2025): Issue 1 (January 2025)
By:
Open Access
|Jun 2025

References

  1. World Health Organization. Global hepatitis report 2024: Action for access in low-and middle-income countries. April 2024. Available from https://www.who.int/publications/i/item/9789240091672 (accessed May 2025).
    Search in Google ScholarBack to article
  2. World Health Organization. Hepatitis B. Available from https://www.who.int/en/news-room/fact-sheets/detail/hepatitis-b (accessed May 2025).
    Search in Google ScholarBack to article
  3. Zampino R, Boemio A, Sagnelli C, et al. 2015. Hepatitis B virus burden in developing countries. World J Gastroenterol 2015; 21(42):11941. doi: 10.3748/wjg.v21.i42.11941.
    Open DOISearch in Google ScholarBack to article
  4. Schweitzer A, Horn J, Mikolajczyk RT, et al. Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013. Lancet 2015; 386(10003):1546–55. doi: 10.1016/S0140-6736(15)61412-X.
    Open DOISearch in Google ScholarBack to article
  5. Kiire C. The epidemiology and prophylaxis of hepatitis B in sub-Saharan Africa: A view from tropical and subtropical Africa. Gut 1996; 38(Suppl 2): S5–12. doi: 10.1136/gut.38.suppl_2.s5.
    Open DOISearch in Google ScholarBack to article
  6. Kew MC. Hepatitis B virus infection: The burden of disease in South Africa. Southern African Journal of Epidemiology and Infection 2008; 23(1): 4–8. doi: 10.1080/10158782.2008.11441293.
    Open DOISearch in Google ScholarBack to article
  7. Shi Y, Zheng M. Hepatitis B virus persistence and reactivation. BMJ 2020; 370: m2200. doi: https://doi.org/10.1136/bmj.m2200
    Search in Google ScholarBack to article
  8. Yip TCF, Wong GLH. Current knowledge of occult hepatitis B infection and clinical implications. Semin Liver Dis 2019; 39(2): 249–60. doi: 10.1055/s-0039-1678728.
    Open DOISearch in Google ScholarBack to article
  9. Raimondo G, Locarnini S, Pollicino T, et al. Update of the statements on biology and clinical impact of occult hepatitis B virus infection. J Hepatol 2019; 71(2):397–408. doi: 10.1016/j.jhep.2019.03.034
    Open DOISearch in Google ScholarBack to article
  10. Ocana S, Casas ML, Buhigas I, Lledo JL. Diagnostic strategy for occult hepatitis B virus infection. World J Gastroenterol 2011; 17(12):1553. doi: 10.3748/wjg.v17.i12.1553.
    Open DOISearch in Google ScholarBack to article
  11. Kramvis A. Molecular characteristics and clinical relevance of African genotypes and subgenotypes of hepatitis B virus. S Afr Med J 2018; 108(8):17–21. doi: 10.7196/samj.2018.v108i8.13495.
    Open DOISearch in Google ScholarBack to article
  12. Hwang EW, Cheung R. Global epidemiology of hepatitis B virus (HBV) infection. North American Journal of Medicine and Science 2011; 4(1):7–13. Available from https://najms.com/index.php/najms/article/view/499 (accessed May 2025).
    Search in Google ScholarBack to article
  13. Im YR, Jagdish R, Leith D, et al. Prevalence of occult hepatitis B virus infection in adults: A systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2022; 7(10): 932–42. doi: 10.1016/S2468-1253(22)00201-1.
    Open DOISearch in Google ScholarBack to article
  14. Weusten J, Van Drimmelen H, Vermeulen M, Lelie N. A mathematical model for estimating residual transmission risk of occult hepatitis B virus infection with different blood safety scenarios. Transfusion 2017; 57(3pt2): 841–9. doi: 10.1111/trf.14050.
    Open DOISearch in Google ScholarBack to article
  15. Candotti D, Boizeau L, Laperche S. Occult hepatitis B infection and transfusion-transmission risk. Transfus Clin Biol 2017; 24(3): 189–95. doi: 10.1016/j.tracli.2017.06.014.
    Open DOISearch in Google ScholarBack to article
  16. Makris M, Preston F, Triger D, et al. Hepatitis c antibody and chronic liver disease in haemophilia. Lancet 1990; 335(8698): 1117–9. doi: 10.1016/0140-6736(90)91124-S.
    Open DOISearch in Google ScholarBack to article
  17. Merritt EC. Infected blood scandal: Background, impacts, interim compensation and inquiry outcomes. [cited 2024; 2024/08/05]. Available from: https://lordslibrary.parliament.uk/infected-blood-scandal-background-impacts-interim-compensation-and-inquiry-outcomes.
    Search in Google ScholarBack to article
  18. Teitel JM. Viral safety of haemophilia treatment products. Ann Med 2000; 32(7):485–92. doi: 10.3109/07853890009002024.
    Open DOISearch in Google ScholarBack to article
  19. Allain JO, Belkhiri D, Vermeulen M, et al. Characterization of occult hepatitis B virus strains in South African blood donors. Hepatology 2009; 49(6): 1868–76. doi: 10.1002/hep.22879.
    Open DOISearch in Google ScholarBack to article
  20. Bell TG, Makondo E, Martinson NA, Kramvis A. Hepatitis B virus infection in human immunodeficiency virus infected southern African adults: Occult or overt–that is the question. PLoS One 2012; 7(10): e45750. doi: 10.1371/journal.pone.0045750.
    Open DOISearch in Google ScholarBack to article
  21. Msomi N|, Ndlovu K, Gianhari J, et al. High rate of occult hepatitis B virus infection in hemodialysis units of KwaZulu-Natal, South Africa. J Med Virol 2019; 91(10): 1797–803. doi: 10.1002/jmv.25510.
    Open DOISearch in Google ScholarBack to article
  22. Javanmard D, Namaei MH, Farahmand M, et al. Molecular and serological characterization of occult hepatitis B virus infection among patients with hemophilia. J Med Virol 2019; 91(8): 1519–27. doi: 10.1002/jmv.25470.
    Open DOISearch in Google ScholarBack to article
  23. Toyoda H, Hayashi K, Murakami Y, et al. Prevalence and clinical implications of occult hepatitis b viral infection in hemophilia patients in Japan. J Med Virol 2004; 73(2): 195–9. doi: 10.1002/jmv.20075.
    Open DOISearch in Google ScholarBack to article
  24. Varaklioti A, Kouramba A, Ioannidou P, Katsarou O. Occult hepatitis B virus infection in Greek patients with congenital bleeding disorders. Infect Genet Evol 2017; 54: 397–401. doi: 10.1016/j.meegid.2017.07.012.
    Open DOISearch in Google ScholarBack to article
  25. Windyga J, Brojer E, Gronowska A, et al. Preliminary results of HBV DNA testing of Polish haemophilia patients–lack of occult HBV infection. Haemophilia 2006; 12(4): 380–3. doi: 10.1111/j.1365-2516.2006.01293.x.
    Open DOISearch in Google ScholarBack to article
  26. Spearman CW, Afihene M, Ally R, et al. Hepatitis B in sub-Saharan Africa: Strategies to achieve the 2030 elimination targets. Lancet Gastroenterol Hepatol 2017; 2(12): 900–9. doi: 10.1016/S2468-1253(17)30295-9.
    Open DOISearch in Google ScholarBack to article
  27. Vermeulen M, Swanevelder R, Van Zyl G, Lelie N, Murphy EL. An assessment of hepatitis B virus prevalence in South African young blood donors born after the implementation of the infant hepatitis B virus immunization program: Implications for transfusion safety. Transfusion 2021; 61(9): 2688–700. doi: 10.1111/trf.16559.
    Open DOISearch in Google ScholarBack to article
  28. European Medicines Agency. Guideline on plasma-derived medicinal products. 21 July 2011. EMA/CHMP/BWP/706271/2010. Available from https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-plasma-derived-medicinal-products_en.pdf (accessed June 2025).
    Search in Google ScholarBack to article
  29. Samal J, Kandpal M. Vivekandandan P. Molecular mechanisms underlying occult hepatitis B virus infection. Clin Microbiol Rev 2012; 25(1): 142–63. doi: 10.1128/CMR.00018-11.
    Open DOISearch in Google ScholarBack to article
DOI: https://doi.org/10.2478/jhp-2025-0009 | Journal eISSN: 2055-3390
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Language: English
Page range: 65 - 70
Published on: Jun 10, 2025
Published by: Haemnet Ltd
In partnership with: Paradigm Publishing Services
Publication frequency: 1 times per year
Keywords:
Haemophilia,
Occult hepatitis B virus,
South Africa
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other,
Clinical medicine,
Clinical medicine, other,
Pharmacy,
Pharmacology

© 2025 O Kgotleng, N Msomi, LD Mthethwa, J Potgieter, JN Mahlangu, M Karodia, NL Ntabeni, published by Haemnet Ltd
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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