Figure 1.
Figure 2.
j_jhp-2024-0019_utab_001
| COMPONENT NUMBER | COMPONENT | MATERIAL |
|---|---|---|
| 1 | Cylinder | Polypropylene (PP) |
| 2 | Fluid part base | Polypropylene (PP) |
| 3 | Septum (injection port) | Silicone, Elastosil |
| 4 | Bushing | Polycarbonate (PC) |
| 5 | Introducer needle | Stainless steel, AiSi 304 |
| 6 | Releaser | Polyoxymethylene copolymer (POM) |
| 7 | Base | Co-polyester |
| 8 | Adhesive patch | Polyester with polyacrylate adhesive |
| 9 | Connector in grey colour | Methyl methacrylate acrylonitrile butadiene styrene (MABS), Terlux 2802 HD, transparent, grey |
| 10 | Cover | Polypropylene (PP), grey |
| 11 | Release button | Polypropylene (PP), red |
| 12 | Luer | Methyl methacrylate acrylonitrile butadiene styrene (MABS), Terlux 2802 HD, transparent |
| 13 | Connector needle | Stainless steel, AiSi 304 |
| 14 | Fixation tape | Bandarole, Flexpeel |
| 15 | Protective cap for connector | Polypropylene (PP) |
| 16 | Blister | Amorphous polyethylene terephthalate/polyethylene (APET/PE) |
| 17 | Blister lid | Medical grade paper |
| 18 | Extruder tube: | Polyethylene (PE) |
| 19 | Reinforcement liner | Polyethylene terephthalate (PET) and acrylic adhesive |
| 20 | Neeedle hub | Polyoxymethylene (POM) |
| 21 | Soft catheter | Polytetrafluoroethylene (PTFE) |
| 22 | Piston | Polyoxymethylene copolymer (POM) |
| 23 | Retraction spring | Stainless steel spring wire (AiSi 302) |
| 24 | Insertion spring | Stainless steel spring wire (AiSi 302) |
| 25 | Base lock | Polypropylene (PP) |
| 26 | N/A | UV glue |
| 27 | N/A | Silicone oil |
Serum emicizumab in the study population after initiation of Neria™ Guard
| PATIENT NO. | TREATMENT INTERVAL | DAYS FROM LAST INJECTION TO BLOOD SAMPLE | DAYS FROM INITIATION OF NERIA™ GUARD TO BLOOD SAMPLE | MEASURED EMICIZUMAB PLASMA LEVELS |
|---|---|---|---|---|
| 1 | Every 14 days | 8 | 36 | 53 μg/L |
| 2 | Every 14 days | 2 | 92 | 62 μg/L |
| 3 | Every 14 days | 8 | 54 | 33 μg/L |
| 4 | 1 × week | 5 | 61 | 71 μg/L |
| 5 | 1 × week | 5 | 61 | 41 μg/L |
| 6 | Every 20 days | No data available | 56 | 52 μg/L |
| 7 | Every 14 days | 1 | 57 | 57 μg/L |
| 8 | Every 14 days | 12 | 72 | 65 μg/L |
| 9 | Every 14 days | 12 | 72 | 62 μg/L |
| 10 | Every 14 days | 9 | 37 | 48 μg/L |
| 11 | 1 × week | 0 | 35 | 49 μg/L |