Diagnostic performance of POC-US for evaluation
| SYNOVIAL HYPERTROPHY | CARTILAGE ABNORMALITY | BONY ABNORMALITY | |
|---|---|---|---|
| True positive | 32 | 6 | 6 |
| True negative | 11 | 34 | 38 |
| False positive | 1 | 0 | 0 |
| False negative | 1 | 5 | 1 |
| Sensitivity | 96.9 | 54.5 | 85.7 |
| Specificity | 91.6 | 100.0 | 100.0 |
| PPV | 96.9 | 100.0 | 100.0 |
| NPV | 91.6 | 87.1 | 97.4 |
| Diagnostic accuracy | 95.5 | 88.8 | 97.7 |
| Kappa value | 0.89 | 0.64 | 0.91 |
Participant demographics (N=42)
| AGE GROUP (YEARS) | NUMBER (N (%)) |
|---|---|
| 10–19 | 18 (42.8%) |
| 20–29 | 18 (42.8%) |
| 30–39 | 4 (9.5%) |
| 40–49 | 2 (4.7%) |
| Mean ± S.D | 21.2 ±7.6 |
| HAEMOPHILIA TYPE | |
| Haemophilia A | 35 (83.3%) |
| Haemophilia B | 7 (16.6%) |
| HAEMOPHILIA SEVERITY | |
| Severe | 24 (57.1%) |
| Moderate | 10 (23.8%) |
| Mild | 8 (19%) |
| FAMILY HISTORY | |
| Positive | 24 (57.1%) |
| Negative | 18 (42.8%) |
Point-of-care ultrasound (POC-US) results for knee and ankle joints in the study cohort (n=42)
| SYNOVIAL HYPERTROPHY | CARTILAGE ABNORMALITY | BONY ABNORMALITY | |
|---|---|---|---|
| Knee | 30 | 6 | 6 |
| Ankle | 3 | 0 | 0 |
| Total | 33 | 6 | 6 |
Magnetic resonance imaging (MRI) results for knee and ankle joints in the study cohort (n=42)
| SYNOVIAL HYPERTROPHY | CARTILAGE ABNORMALITY | BONY ABNORMALITY | |
|---|---|---|---|
| Knee | 30 | 10 | 6 |
| Ankle | 3 | 1 | 1 |
| Total | 33 | 11 | 7 |
Comparision of the POC-US and MRI findings of the involved knee and ankle joints
| KNEES (N =) | ANKLES (N =) | OVERALL (N =) | |||||
|---|---|---|---|---|---|---|---|
| MRI− | MRI+ | MRI− | MRI+ | MRI− | MRI+ | ||
| Synovial hypertrophy | POC-US− | 11 | 1 | 0 | 0 | 11 | 1 |
| POC-US+ | 1 | 29 | 0 | 3 | 1 | 32 | |
| Bone irregularities | POC-US− | 35 | 1 | 3 | 0 | 38 | 1 |
| POC-US+ | 0 | 6 | 0 | 0 | 0 | 6 | |
| Cartilage abnormalities | POC-US− | 31 | 5 | 3 | 0 | 34 | 5 |
| POC-US+ | 0 | 6 | 0 | 0 | 0 | 6 | |