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Bone health assessment in haemophilic arthropathy: A single centre study from Kolkata, West Bengal, India Cover

Bone health assessment in haemophilic arthropathy: A single centre study from Kolkata, West Bengal, India

Open Access
|Mar 2022

Figures & Tables

Measuring bone mineral density is key to determining the risk and presence of osteoporosis, a potential comorbidity for people with haemophilia linked to joint bleeds, inflammation and arthropathy. In countries where DEXA scanning facilities are not widely available, bone turnover markers like b-ALP may be useful in assessing joint health.© Shutterstock
Measuring bone mineral density is key to determining the risk and presence of osteoporosis, a potential comorbidity for people with haemophilia linked to joint bleeds, inflammation and arthropathy. In countries where DEXA scanning facilities are not widely available, bone turnover markers like b-ALP may be useful in assessing joint health.© Shutterstock

Parameters included in Pettersson score [18]

RADIOGRAPHIC PARAMETERFINDING(S)SCORE

OsteoporosisAbsent0
Present1

Enlarged epiphysisAbsent0
Present1

Irregular subchondral surfaceAbsent0
Slight1
Pronounced2

Narrowing of joint spaceAbsent0
< 50%1
> 50%2

Subchondral cyst formationAbsent0
One cyst1
More than one cyst2

Erosions at joint marginsAbsent0
Present1

Gross incongruence of articulating bone ends (angulation/displacement)Absent0
Slight1
Pronounced2

Joint deformityAbsent0
Slight1
Pronounced2

Distribution of joint health scoring and biochemical parameters in different age groups

AGE GROUPS1 TO 5 YEARS (N=21)>5 TO 10 YEARS (N=67)>10 TO 15 YEARS (N=66)> 15 YEARS (N=166)
No. of joints affected (mean ± SD)3.81±1.474.88±2.255.22±2.295.56±2.37
HJHS (mean ± SD)13.71±2.8114.29±2.3914.60±2.2414.26±2.37
Peterson score (mean ± SD)10.14±1.459.76±1.9810.12±1.631610.13±1.81
Calcium (mean ± SD)9.91±0.509.66±0.629.77±0.609.53±0.58
Low serum calcium (age/sex adjusted)0% (0/21)8.9% (6/67)6.06% (4/66)21.08% (35/166)
Phosphorus (mean ± SD)4.42±0.734.57±0.653.95±0.803.56±0.61
Low serum phosphorus (age/sex adjusted)28.57% (6/21)17.91% (12/67)13.63% (9/66)9.03% (15/166)
Vitamin D3 (ng/dl);(mean ± SD)12.88±5.2414.84±7.2116.35±9.3117.04±7.57
Low vitamin D3 (<20 ng/dl); (% (n))90 % (18/21)82.09% (55/67)71.2% (47/66)71.69%(119/166)
b-ALP (ug/L); (mean ± SD)116.67±11.2149.62±23.09197.95±29.0242.07±29.691
High b-ALP (age/sex adjusted); (% (n))76.19 % (16/21)86.57 % (58/67)80.33% (53/66)94.57 % (157/166)
ALP (U/L); (mean ± SD)119.42±18.92103.79±20.73117.09±24.61104.75±23.72
Language: English
Page range: 183 - 188
Published on: Mar 2, 2022
Published by: Haemnet Ltd
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year

© 2022 Prakas Kumar Mandal, Malini Garg, Prantar Chakrabarti, Amrita Bhowmik, Debasis Gantait, Tuphan Kanti Dolai, published by Haemnet Ltd
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.