A Metric Approach to Hot Topics in Biomedicine via Keyword Co-occurrence

Figures & Tables

Rank	Keyword	Degree Centrality	Keyword	Betweenness Centrality
1	STEM CELL	184	STEM CELL	359.39
2	EMBRYONIC STEM CELL	170	EMBRYONIC STEM CELL	267.07
3	REPROGRAMMING	166	HUMAN IPSC	254.20
4	HUMAN IPSC	162	REPROGRAMMING	246.40
5	PLURIPOTENT STEM CELL	160	DIFFERENTIATION	225.41
6	DIFFERENTIATION	158	PLURIPOTENT STEM CELL	221.89
7	REGENERATIVE MEDICINE	118	HUMAN EMBRYONIC STEM CELL	110.40
8	HUMAN EMBRYONIC STEM CELL	116	REGENERATIVE MEDICINE	100.92
9	NEURAL STEM CELL	116	MESENCHYMAL STEM CELL	94.19
10	MESENCHYMAL STEM CELL	114	NEURAL STEM CELL	83.66
11	CELL THERAPY	102	TRANSPLANTATION	70.11
12	PLURIPOTENCY	102	PLURIPOTENCY	67.90
13	TRANSPLANTATION	102	CELL THERAPY	60.74
14	TISSUE ENGINEERING	98	CARDIOMYOCYTES	58.25
15	CARDIOMYOCYTES	90	NEURON	56.58
16	NEURON	90	TISSUE ENGINEERING	54.92
17	DISEASE MODELING	82	HIPSC	43.86
18	HIPSC	82	DRUG SCREENING	42.39
19	PARKINSON’S DISEASE	82	GENE EXPRESSION	40.25
20	GENE EXPRESSION	80	DISEASE MODELING	37.50

Rank	Keyword	Degree	Keyword	Betweennes
		Centrality		Centrality
1	METABOLIC ENGINEERING	100	METABOLIC ENGINEERING	378.42
2	YEAST	90	GENE EXPRESSION	312.93
3	GENE CIRCUIT	82	YEAST	286.57
4	ES CELLHERICHIA COLI	80	GENE CIRCUIT	281.48
5	GENE EXPRESSION	80	ES CELLHERICHIA COLI	249.28
6	SACCHAROMYCES CEREVISIAE	80	SACCHAROMYCES CEREVISIAE	229.17
7	PROTEIN ENGINEERING	66	SYNTHETIC GENE	180.28
8	DIRECTED EVOLUTION	62	PROTEIN ENGINEERING	171.01
9	GENE REGULATION	60	CELL CYCLE	169.32
10	SYNTHETIC GENE	60	GENE THERAPY	158.88
11	SYSTEMS BIOLOGY	60	TRANSCRIPTION	146.23
12	TRANSCRIPTION	60	DIRECTED EVOLUTION	143.33
13	GENE ENGINEERING	56	SYSTEMS BIOLOGY	130.95
14	BIOTECHNOLOGY	50	GENE REGULATION	108.56
15	GENE THERAPY	50	GENE ENGINEERING	90.24
16	CRISPR/CAS9	48	ESSENTIAL GENE	87.67
17	CYANOBACTERIA	46	CELL-FREE PROTEIN SYNTHESIS	76.44
18	ESSENTIAL GENE	46	EVOLUTION	71.90
19	EVOLUTION	44	TRANSCRIPTION FACTOR	70.90
20	E. COLI	42	BIOTECHNOLOGY	66.57

Rank	Keyword	Degree Centrality	Keyword	Betweenness Centrality
1	CRISPR	188	CRISPR	1,378.00
2	GENOME EDITING	156	GENOME EDITING	664.00
3	CRISPR/CAS	132	CRISPR/CAS	441.37
4	GENOME ENGINEERING	94	GENOME ENGINEERING	157.52
5	HOMOLOGOUS RECOMBINATION	84	GENES	135.44
6	GENES	76	HOMOLOGOUS RECOMBINATION	111.44
7	ZEBRAFISH	70	ZEBRAFISH	110.97
8	GENE TARGET	66	GENE REGULATION	60.97
9	TALEN	64	CRISPRI	53.39
10	SYNTHETIC BIOLOGY	58	APOPTOSIS	49.33
11	GENE REGULATION	56	DNA REPAIR	48.34
12	GENE THERAPY	56	SYNTHETIC BIOLOGY	47.97
13	DNA REPAIR	54	GENE TARGET	47.13
14	GENE KNOCKOUT	54	IPSC	42.64
15	IPSC	50	GENE KNOCKOUT	41.15
16	ZFN	50	TALEN	41.09
17	SGRNA	46	GENE THERAPY	39.40
18	CANCER	42	EVOLUTION	37.89
19	CRRNA	42	SGRNA	34.15
20	EVOLUTION	42	CANCER	34.14