FIGURE 1.

FIGURE 2.

FIGURE 3.

FIGURE 4.

Lp(a) cut-off values according to different guidelines
| Recommendation | Lp(a) cut-off values |
|---|---|
| Polish Lipid Association 202120 |
|
| HEART UK consensus 20198 |
|
| European Society of Cardiology/European Atherosclerosis Society 20197 |
|
The factors that influence Lp(a) levels2,3,15,16,17
| Factors increasing Lp(a) levels | Factors decreasing Lp(a) levels |
|---|---|
|
|
Pro-atherogenic and prothrombotic mechanisms of Lp(a)4
| Pro-atherogenic and pro-inflammatory properties of Lp(a) | Prothrombotic properties of Lp(a) |
|---|---|
| ↑ oxidized phospholipids | ↓ plasminogen activation |
| ↑ foam cell formation | ↓ fibrinolysis |
| ↑ endothelial dysfunction | ↓ tissue factor pathway inhibitor |
| ↑ smooth muscle cell proliferation | ↓ clot stability |
| ↑ monocyte chemotaxis | ↑ platelet response |
| ↑ arterial wall inflammation (IL-8, monocyte chemotactic protein, TNF-α) | ↑ plasminogen activator inhibitor-1 (PAI-1) |