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The Effects of Postoperative Trimetazidine Treatment on Ischemia-Reperfusion Injury after Isolated Surgical Myocardial Revascularization Cover

The Effects of Postoperative Trimetazidine Treatment on Ischemia-Reperfusion Injury after Isolated Surgical Myocardial Revascularization

Open Access
|Sep 2024

Figures & Tables

hs-TNT levels in the two groups

VariableStudy group (n = 45)Control group (n = 45)p value
12 h before surgery (%)19.9 ± 1.1 (18.3–22.1)20.5 ± 2.1 (18.3–31.1)>0.05
12 h after surgery (%)187.2 ± 8.9 (165–206)186.8 ± 12.5 (166–221)>0.05
6 months after surgery (%)19.4 ± 1.1 (17.9–22)19.6 ± 1.2 (18.1–22.3)>0.05

MDA levels in the two groups

VariableStudy group (n = 45)Control group (n = 45)p value
12- h before surgery (µmol/ml)236 ± 11 (223–243)232 ± 12 (219–244)>0.05
12- h after surgery (µmol/ml)287 ± 18 (269–303)284 ± 20 (264–300)>0.05
1- month after surgery (µmol/ml)227 ± 9 (211–233)270 ± 14 (260–282)<0.05
6- months after surgery (µmol/ml)211 ± 7 (205–216)231 ± 13 (221–239)<0.05

Postoperative data

VariableStudy group (n = 45)Control group (n = 45)p value
Cardiac ward stay (h)23.4 ± 2.9 (17–29)23.3 ± 2.6 (18–28)>0.05
In-hospital stay (days)6.8 ± 0.8 (5–8)7.1 ± 0.7 (5–8)<0.05
Total blood loss (ml)255.7 ± 60.6 (170–410)276 ± 66.2 (180–440)>0.05

Intraoperative data

VariableStudy group (n = 45)Control group (n = 45)p value
CPB time (min), mean ± s.d. (range)43.7 ± 3.3 (38–51)43.5 ± 3.8 (38–55)>0.05
Aortic cross-clamp time (min), mean ± s.d. (range)27.4 ± 2.5 (22–31)28.2 ± 2.7 (21–34)>0.05
Number of bypass grafts performed, n135135>0.05
Venous bypass grafts, n9090>0.05
Off-pump procedures, nnilnil

Demographic and preoperative characteristics

VariableStudy group (n = 45)Control group (n = 45)p value
Male sex, n (%)34 (75.6%)33 (73.3%)>0.05
Age (years)62.97±9.45 (55–72)64.18±6.54 (52–75)>0.05
BMI29.3 (23.1–32.4)29.6 (24.2–31.9)>0.05
Diabetes type 2, n (%)45 (100%)45 (100%)>0.05
Arterial hypertension, n (%)31 (68.8%)29 (64%9)>0.05
Hyperlipidemia, n (%)30 (66.6%)31 (68.8%)>0.05
Elective surgery, n (%)45 (100%)45 (100%)>0.05
Patients with implanted stents, n (%)11 (24%)14 (31%)>0.05
Total number of stents deployed, n1619>0.05
EuroSCORE II, mean ± s.d.1.6 ± 0.41.5 ± 0.7>0.05

LVEF in the two groups

VariableStudy group (n = 45)Control group (n = 45)p value
12 h before surgery (%)44.1 ± 0.2 (41–51)45.2 ± 2.7 (41–51)>0.05
1 h after surgery (%)43.8 ± 5.7 (38–48)44.6 ± 3.2 (39–51)>0.05
On discharge (%)47.5 ± 2.8 (43–53)47.8 ± 2.9 (43–55)>0.05
6 months after surgery (%)54.4 ± 3.2 (48–62)53.9 ± 3.0 (49–57)>0.05

CK-MB levels in the two groups

VariableStudy group (n = 45)Control group (n = 45)p value
12 h before surgery (%)2.9 ± 0.2 (2.4–3.6)2.9 ± 0.2 (2.4–3.5)>0.05
12 h after surgery (%)37.9 ± 5.7 (29–49)37 ± 5.9 (27–49)>0.05
6 months after surgery (%)3.1 ± 0.4 (2.1–3.8)3.2 ± 0.3 (2.7–3.8)>0.05
DOI: https://doi.org/10.2478/jce-2024-0019 | Journal eISSN: 2457-5518 | Journal ISSN: 2457-550X
Language: English
Page range: 89 - 94
Submitted on: Jun 25, 2024
Accepted on: Sep 15, 2024
Published on: Sep 30, 2024
Published by: Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year

© 2024 Stanev Kamen, Dobreva-Yatseva Bistra, Gonovski Todor, Ivanov Asen, Nachev Gencho, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.