Elevated Composite Inflammatory Markers are Associated with Clinical Severity and Long-term Amputation Risk in Patients with Critical Limb Ischemia after Percutaneous Transluminal Angioplasty
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References
- Conte MS, Bradbury AW, Kolh P, et al. Global vascular guidelines on the management of chronic limb-threatening ischemia. J Vasc Surg. 2019;69(6S):3S–125S.e40. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.jvs.2019.02.016" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.jvs.2019.02.016</a></pub-id>
- Aboyans V, Ricco JB, Bartelink MLEL, et al. Editor’s Choice – 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS). European Journal of Vascular and Endovascular Surgery. 2018;55(3):305–368. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.ejvs.2017.07.018" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.ejvs.2017.07.018</a></pub-id>
- Fontaine R, Kim M, Kieny R. [Surgical treatment of peripheral circulation disorders]. Helv Chir Acta. 1954;21(5–6):499–533.
- Baubeta Fridh E, Andersson M, Thuresson M, et al. Amputation Rates, Mortality, and Pre-operative Comorbidities in Patients Revascularised for Intermittent Claudication or Critical Limb Ischaemia: A Population Based Study. Eur J Vasc Endovasc Surg. 2017;54(4):480–486. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.ejvs.2017.07.005" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.ejvs.2017.07.005</a></pub-id>
- Signorelli SS, Anzaldi M, Libra M, et al. Plasma Levels of Inflammatory Biomarkers in Peripheral Arterial Disease: Results of a Cohort Study. Angiology. 2016;67(9):870–874. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1177/0003319716633339" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1177/0003319716633339</a></pub-id>
- Igari K, Kudo T, Toyofuku T, Inoue Y. Relationship of Inflammatory Biomarkers with Severity of Peripheral Arterial Disease. Int J Vasc Med. 2016;2016:6015701. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1155/2016/6015701" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1155/2016/6015701</a></pub-id>
- Onofrei V, Crișan A, Adam CA, et al. The Role Played by Novel Inflammatory Markers in Assessment of Peripheral Artery Disease. Medicina. 2023;59(9):1557. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/medicina59091557" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/medicina59091557</a></pub-id>
- Kaller R, Russu E, Arbănași EM, et al. Intimal CD31-Positive Relative Surfaces Are Associated with Systemic Inflammatory Markers and Maturation of Arteriovenous Fistula in Dialysis Patients. Journal of Clinical Medicine. 2023;12(13):4419. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/jcm12134419" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/jcm12134419</a></pub-id>
- Niculescu R, Russu E, Arbănași EM, et al. Carotid Plaque Features and Inflammatory Biomarkers as Predictors of Restenosis and Mortality Following Carotid Endarterectomy. International Journal of Environmental Research and Public Health. 2022;19(21):13934. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/ijerph192113934" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/ijerph192113934</a></pub-id>
- Kaller R, Arbănași EM, Mureșan AV, et al. The Predictive Value of Systemic Inflammatory Markers, the Prognostic Nutritional Index, and Measured Vessels’ Diameters in Arteriovenous Fistula Maturation Failure. Life. 2022;12(9):1447. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/life12091447" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/life12091447</a></pub-id>
- Arbănași EM, Mureșan AV, Coșarcă CM, et al. Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Impact on Predicting Outcomes in Patients with Acute Limb Ischemia. Life. 2022;12(6):822. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/life12060822" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/life12060822</a></pub-id>
- Russu E, Mureșan AV, Arbănași EM, et al. The Predictive Role of NLR and PLR in Outcome and Patency of Lower Limb Revascularization in Patients with Femoropopliteal Disease. Journal of Clinical Medicine. 2022;11(9):2620. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/jcm11092620" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/jcm11092620</a></pub-id>
- Arbănași EM, Mureșan AV, Arbănași EM, et al. The Neutrophil-to-Lymphocyte Ratio’s Predictive Utility in Acute Pulmonary Embolism: Systematic Review. Journal Of Cardiovascular Emergencies. 2022;8(2):25–30. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.2478/jce-2022-0005" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.2478/jce-2022-0005</a></pub-id>
- Lăpădatu BI, Russu E. Neutrophil-to-Lymphocyte Ratio – Risk of Amputation and Mortality in Patients with Limb-Threatening Ischemia – a Systematic Review. Journal of Cardiovascular Emergencies. 2024;10(1):7–12. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.2478/jce-2024-0006" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.2478/jce-2024-0006</a></pub-id>
- Mureșan AV, Hălmaciu I, Arbănași EM, et al. Prognostic Nutritional Index, Controlling Nutritional Status (CONUT) Score, and Inflammatory Biomarkers as Predictors of Deep Vein Thrombosis, Acute Pulmonary Embolism, and Mortality in COVID-19 Patients. Diagnostics. 2022;12(11):2757. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/diagnostics12112757" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/diagnostics12112757</a></pub-id>
- Arbănași EM, Halmaciu I, Kaller R, et al. Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients. Diagnostics. 2022;12(10):2379. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/diagnostics12102379" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/diagnostics12102379</a></pub-id>
- Halmaciu I, Arbănași EM, Kaller R, et al. Chest CT Severity Score and Systemic Inflammatory Biomarkers as Predictors of the Need for Invasive Mechanical Ventilation and of COVID-19 Patients’ Mortality. Diagnostics. 2022;12(9):2089. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/diagnostics12092089" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/diagnostics12092089</a></pub-id>
- Russu E, Arbănaşi EM, Șchiopu A. Special Issue “COVID-19 Coagulopathy: Advances on Pathophysiology and Therapies.” International Journal of Molecular Sciences. 2024;25(6):3548. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/ijms25063548" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/ijms25063548</a></pub-id>
- Stoian M, Andone A, Boeriu A, et al. COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit. Antibiotics. 2024;13(4):367. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/antibiotics13040367" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/antibiotics13040367</a></pub-id>
- Stoian A, Bajko Z, Stoian M, et al. The Occurrence of Acute Disseminated Encephalomyelitis in SARS-CoV-2 Infection/Vaccination: Our Experience and a Systematic Review of the Literature. Vaccines. 2023;11(7):1225. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/vaccines11071225" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/vaccines11071225</a></pub-id>
- Hogea T, Suciu BA, Chinezu L, et al. Pregnancy-Associated Spontaneous Coronary Acute Dissection as a Cause of Sudden Cardiac Death—Autopsy Findings and Literature Review: Is COVID-19 Related? Medicina. 2023;59(7):1257. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/medicina59071257" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/medicina59071257</a></pub-id>
- Arbănași EM, Kaller R, Mureșan AV, Voidăzan S, Arbanasi EM, Russu E. Impact of COVID-19 pandemic on Vascular Surgery Unit activity in Central Romania. Front Surg. 2022;9:883935. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3389/fsurg.2022.883935" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3389/fsurg.2022.883935</a></pub-id>
- Mureșan AV, Russu E, Arbănași EM, et al. Negative Impact of the COVID-19 Pandemic on Kidney Disease Management—A Single-Center Experience in Romania. Journal of Clinical Medicine. 2022;11(9):2452. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/jcm11092452" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/jcm11092452</a></pub-id>
- Bui QT, Prempeh M, Wilensky RL. Atherosclerotic plaque development. Int J Biochem Cell Biol. 2009;41(11):2109–2113. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.biocel.2009.06.002" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.biocel.2009.06.002</a></pub-id>
- Sakakura K, Nakano M, Otsuka F, Ladich E, Kolodgie FD, Virmani R. Pathophysiology of atherosclerosis plaque progression. Heart Lung Circ. 2013;22(6):399–411. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.hlc.2013.03.001" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.hlc.2013.03.001</a></pub-id>
- Feldman CL, Stone PH. Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque. Curr Opin Cardiol. 2000;15(6):430–440. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1097/00001573-200011000-00010" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1097/00001573-200011000-00010</a></pub-id>
- Cicha I, Wörner A, Urschel K, et al. Carotid plaque vulnerability: a positive feedback between hemodynamic and biochemical mechanisms. Stroke. 2011;42(12):3502–3510. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1161/STROKEAHA.111.627265" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1161/STROKEAHA.111.627265</a></pub-id>
- Kazantsev AN, Korotkikh AV, Chernyavin MP, et al. Vertebral triangle of doctor A.N. Kazantsev - double vertebral artery in V3 segment. Radiol Case Rep. 2023;18(7):2370–2375. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.radcr.2023.03.057" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.radcr.2023.03.057</a></pub-id>
- De Nisco G, Hoogendoorn A, Chiastra C, et al. The impact of helical flow on coronary atherosclerotic plaque development. Atherosclerosis. 2020;300:39–46. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.atherosclerosis.2020.01.027" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.atherosclerosis.2020.01.027</a></pub-id>
- Liu Y, Luo X, Jia H, Yu B. The Effect of Blood Pressure Variability on Coronary Atherosclerosis Plaques. Front Cardiovasc Med. 2022;9:803810. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3389/fcvm.2022.803810" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3389/fcvm.2022.803810</a></pub-id>
- Hansson GK, Libby P, Tabas I. Inflammation and plaque vulnerability. J Intern Med. 2015;278(5):483–493. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1111/joim.12406" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1111/joim.12406</a></pub-id>
- Zhu Y, Xian X, Wang Z, et al. Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules. 2018;8(3):80. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/biom8030080" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/biom8030080</a></pub-id>
- Lutgens E, van Suylen RJ, Faber BC, et al. Atherosclerotic Plaque Rupture. Arteriosclerosis, Thrombosis, and Vascular Biology. 2003;23(12):2123–2130. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1161/01.ATV.0000097783.01596.E2" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1161/01.ATV.0000097783.01596.E2</a></pub-id>
- Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105(9):1135–1143. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1161/hc0902.104353" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1161/hc0902.104353</a></pub-id>
- Barani J, Nilsson JA, Mattiasson I, Lindblad B, Gottsäter A. Inflammatory mediators are associated with 1-year mortality in critical limb ischemia. J Vasc Surg. 2005;42(1):75–80. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.jvs.2005.03.025" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.jvs.2005.03.025</a></pub-id>
- Gremmels H, Teraa M, de Jager SCA, Pasterkamp G, de Borst GJ, Verhaar MC. A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia. Sci Rep. 2019;9(1):10740. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1038/s41598-019-47217-1" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1038/s41598-019-47217-1</a></pub-id>
- Flex A, Gaetani E, Angelini F, et al. Pro-inflammatory genetic profiles in subjects with peripheral arterial occlusive disease and critical limb ischemia. J Intern Med. 2007;262(1):124–130. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1111/j.1365-2796.2007.01791.x" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1111/j.1365-2796.2007.01791.x</a></pub-id>
- Ferreira J, Carneiro A, Vila I, et al. Inflammation and Loss of Skeletal Muscle Mass in Chronic Limb Threatening Ischemia. Ann Vasc Surg. 2023;88:164–173. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.avsg.2022.07.009" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.avsg.2022.07.009</a></pub-id>
- Ferreira J, Afonso J, Longatto-Filho A, et al. Inflammation Is a Histological Characteristic of Skeletal Muscle in Chronic Limb Threatening Ischemia. Ann Vasc Surg. 2024;99:10–18. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.avsg.2023.09.094" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.avsg.2023.09.094</a></pub-id>
- Ferreira J, Roque S, Lima Carneiro A, et al. Reversion of the Inflammatory Markers in Patients With Chronic Limb-Threatening Ischemia. J Am Heart Assoc. 2024;13(8):e031922. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1161/JAHA.123.031922" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1161/JAHA.123.031922</a></pub-id>
- Candemir M, Kiziltunç E, Nurkoç S, Şahinarslan A. Relationship Between Systemic Immune-Inflammation Index (SII) and the Severity of Stable Coronary Artery Disease. Angiology. 2021;72(6):575–581. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1177/0003319720987743" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1177/0003319720987743</a></pub-id>
- Mangalesh S, Dudani S, Mahesh NK. Development of a Novel Inflammatory Index to Predict Coronary Artery Disease Severity in Patients With Acute Coronary Syndrome. Angiology. 2024;75(3):231–239. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1177/00033197231151564" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1177/00033197231151564</a></pub-id>
- Yang YL, Wu CH, Hsu PF, et al. Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. Eur J Clin Invest. 2020;50(5):e13230. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1111/eci.13230" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1111/eci.13230</a></pub-id>
- Oflar E, Akdeniz E, Yıldız C, et al. Evaluation of systemic immune-inflammation index for predicting severity of lower extremity arterial disease. Vascular. Published online May 5, 2024:17085381241251772. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1177/17085381241251772" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1177/17085381241251772</a></pub-id>
- Aktemur T, Demirci G, Tasbulak O, et al. A Simple Predictor for Long-Term Mortality After Percutaneous Iliac Artery Intervention: Systemic Immune Inflammatory Index. Ann Vasc Surg. 2023;96:276–283. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1016/j.avsg.2023.03.012" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1016/j.avsg.2023.03.012</a></pub-id>
- Wang P, Guo X, Zhou Y, et al. Monocyte-to-high-density lipoprotein ratio and systemic inflammation response index are associated with the risk of metabolic disorders and cardiovascular diseases in general rural population. Front Endocrinol (Lausanne). 2022;13:944991. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3389/fendo.2022.944991" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3389/fendo.2022.944991</a></pub-id>
- Xia Y, Xia C, Wu L, Li Z, Li H, Zhang J. Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults. J Clin Med. 2023;12(3):1128. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/jcm12031128" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/jcm12031128</a></pub-id>
- Dziedzic EA, Gąsior JS, Tuzimek A, et al. Investigation of the Associations of Novel Inflammatory Biomarkers-Systemic Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI)-With the Severity of Coronary Artery Disease and Acute Coronary Syndrome Occurrence. Int J Mol Sci. 2022;23(17):9553. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.3390/ijms23179553" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.3390/ijms23179553</a></pub-id>
- Li Y, Bai G, Gao Y, et al. The Systemic Immune Inflammatory Response Index Can Predict the Clinical Prognosis of Patients with Initially Diagnosed Coronary Artery Disease. Journal of Inflammation Research. 2023;16:5069. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.2147/JIR.S432506" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.2147/JIR.S432506</a></pub-id>
- Liu Y, Liu J, Liu L, et al. Association of Systemic Inflammatory Response Index and Pan-Immune-Inflammation-Value with Long-Term Adverse Cardiovascular Events in ST-Segment Elevation Myocardial Infarction Patients After Primary Percutaneous Coronary Intervention. J Inflamm Res. 2023;16:3437–3454. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.2147/JIR.S421491" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.2147/JIR.S421491</a></pub-id>
- Han K, Shi D, Yang L, et al. Prognostic value of systemic inflammatory response index in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Ann Med. 2022;54(1):1667–1677. doi: <pub-id pub-id-type="doi"><a href="https://doi.org/10.1080/07853890.2022.2083671" target="_blank" rel="noopener noreferrer" class="text-signal-blue hover:underline">10.1080/07853890.2022.2083671</a></pub-id>
Language: English
Page range: 102 - 110
Submitted on: May 9, 2024
Accepted on: Jun 26, 2024
Published on: Sep 30, 2024
Published by: Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
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© 2024 Adrian Vasile Mureșan, Nicolae-Alexandru Lazăr, Reka Bartus, Ludovic-Alexandru Szanto, Bogdan Andrei Cordoș, Bogdan-Corneliu Bandici, Suzana-Vasilica Șincaru, Carina Diana Covalcic, Agatha Maria Ilioniu, Lucian Mărginean, published by Asociatia Transilvana de Terapie Transvasculara si Transplant KARDIOMED
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