Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Roxana Buzas; Alexandru Florin Rogobete; Sonia Elena Popovici; Tudor Mateescu; Teodora Hoinoiu; Virgiliu-Bogdan Sorop; Tiberiu Bratu; Marian Ticlea; Calin Marius Popoiu; Dorel Sandesc

doi:10.2478/jce-2018-0008

References

1. Mitropoulos FA, Odim J, Marelli D, et al. Outcome of hearts with cold ischemic time greater than 300 minutes. A casematched study. Eur J Cardiothorac Surg. 2005;28:143-148. doi: 10.1016/j.ejcts.2005.01.067.10.1016/j.ejcts.2005.01.06715982597
Open DOI Search in Google Scholar Back to article
2. Tonkin AM, Blankenberg S, Kirby A, et al. Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study. Int J Cardiol. 2015;201:499-507. doi: 10.1016/j.ijcard.2015.07.080.10.1016/j.ijcard.2015.07.08026318511
Open DOI Search in Google Scholar Back to article
3. Vella RK, Pullen C, Coulson FR, Fenning AS. Resveratrol Prevents Cardiovascular Complications in the SHR/STZ Rat by Reductions in Oxidative Stress and Inflammation. Biomed Res Int. 2015;2015:918123. doi: 10.1155/2015/918123.10.1155/2015/918123435272725802871
Search in Google Scholar Back to article
4. Melania L, Alexandru B, Rogobete F, et al. The Use of Redox Expression and Associated Molecular Damage to Evaluate the Inflammatory Response in Critically Ill Patient with Severe Burn. Biochem Genet. 2016;54:753-768. doi: 10.1007/s10528-016-9763-810.1007/s10528-016-9763-827465592
Open DOI Search in Google Scholar Back to article
5. Rogobete AF, Sandesc D, Papurica M, et al. The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review. Burn Trauma. 2017;5:8. doi: 10.1186/s41038-017-0073-0.10.1186/s41038-017-0073-0534143228286784
Open DOI Search in Google Scholar Back to article
6. Yang Y, Lv J, Jiang S, et al. The emerging role of Toll-like receptor 4 in myocardial inflammation. Cell Death Dis. 2016;7:e2234. doi: 10.1038/cddis.2016.140.10.1038/cddis.2016.140491766927228349
Open DOI Search in Google Scholar Back to article
7. Weiss JBW, Eisenhardt SU, Stark GB, Bode C, Moser M, Grundmann S. MicroRNAs in ischemia-reperfusion injury. Am J Cardiovasc Dis. 2012;2:237-247.
Search in Google Scholar Back to article
8. Mansour Z, Charles AL, Kindo M, et al. Remote effects of lower limb ischemia-reperfusion: Impaired lung, unchanged liver, and stimulated kidney oxidative capacities. Biomed Res Int. 2014;2014:392390. doi: 10.1155/2014/392390.10.1155/2014/392390414255425180180
Search in Google Scholar Back to article
9. David VL, Ercisli MF, Rogobete AF, et al. Early Prediction of Sepsis Incidence in Critically Ill Patients Using Specific Genetic Polymorphisms. Biochem Genet. 2017;55:193-203. doi: 10.1007/s10528-016-9785-2.10.1007/s10528-016-9785-227943002
Open DOI Search in Google Scholar Back to article
10. Kloppenborg RP, Nederkoorn PJ, van der Graaf Y, Geerlings MI. Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMARTMR study. Atherosclerosis. 2011;216:461-466. doi: 10.1016/j.atherosclerosis.2011.02.027.10.1016/j.atherosclerosis.2011.02.02721411090
Search in Google Scholar Back to article
11. Bedreag OH, Rogobete AF, Sandesc D, et al. The Effects of Homocysteine Level in the Critically Ill Patient. A Review. Journal of Interdisciplinary Medicine. 2016;1:131-136. doi: 10.1515/jim-2016-0025.10.1515/jim-2016-0025
Open DOI Search in Google Scholar Back to article
12. Li H, Horke S, Förstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis. 2014;237:208-219. doi: 10.1016/j.atherosclerosis.2014.09.001.10.1016/j.atherosclerosis.2014.09.00125244505
Open DOI Search in Google Scholar Back to article
13. Bedreag OH, Rogobete AF, Cradigati CA, et al. A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs. Romanian Journal of Laboratory Medicine. 2016;24:21-30. doi: 10.1515/rrlm-2016-0015.10.1515/rrlm-2016-0015
Open DOI Search in Google Scholar Back to article
14. Gareus R, Kotsaki E, Xanthoulea S, et al. Article Endothelial Cell-Specific NF-k B Inhibition Protects Mice from Atherosclerosis. Cell Metab. 2008;8:372-383. doi: 10.1016/j.cmet.2008.08.016.10.1016/j.cmet.2008.08.01619046569
Search in Google Scholar Back to article
15. Papurica M, Rogobete AF, Sandesc D, et al. The Expression of Nuclear Transcription Factor Kappa B (NF-κB) in the Case of Critically Ill Polytrauma Patients with Sepsis and Its Interactions with microRNAs. Biochem Genet. 2016;54:337-347. doi: 10.1007/s10528-016-9727-z.10.1007/s10528-016-9727-z27003424
Open DOI Search in Google Scholar Back to article
16. Bedreag OH, Rogobete AF, Sărăndan M, et al. Oxidative stress and antioxidant therapy in traumatic spinal cord injuries. Rom J Anaesth Intensive Care. 2014;21:123-129.
Search in Google Scholar Back to article
17. Bedreag OH, Rogobete AF, Sarandan M, et al. Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma – a review. Anaesthesiol Intensive Ther. 2015;47:351-359. doi: 10.5603/AIT.a2015.0030.10.5603/AIT.a2015.003026037258
Open DOI Search in Google Scholar Back to article
18. Bedreag OH, Sandesc D, Chiriac SD, et al. The Use of Circulating miRNAs as Biomarkers for Oxidative Stress in Critically Ill Polytrauma Patients. Clin Lab. 2016;62:263-274. doi: 10.7754/Clin.Lab.2015.150740.10.7754/Clin..2015.150740
Open DOI Search in Google Scholar Back to article
19. Papurica M, Rogobete AF, Sandesc D, et al. Advances in biomarkers in critical ill polytrauma patients. Clin Lab. 2016;62:977-986. doi: 10.7754/Clin.Lab.2015.151103.10.7754/Clin..2015.151103
Open DOI Search in Google Scholar Back to article
20. Horhat FG, Gundogdu F, David LV, et al. Early Evaluation and Monitoring of Critical Patients with Acute Respiratory Distress Syndrome (ARDS) Using Specific Genetic Polymorphisms. 2017;55:204-211. doi: 10.1007/s10528-016-9787-0.10.1007/s10528-016-9787-028070694
Open DOI Search in Google Scholar Back to article
21. Papurica M, Rogobete AF, Sandesc D, et al. Redox Changes Induced by General Anesthesia in Critically Ill Patients with Multiple Traumas. Mol Biol Int. 2015;2015:238586. doi: 10.1155/2015/238586.10.1155/2015/238586467461526693352
Search in Google Scholar Back to article
22. Dumache R, Rogobete AF, Bedreag OH, et al. Use of miRNAs as Biomarkers in Sepsis. Anal Cell Pathol (Amst). 2015;2015:186716. doi: 10.1155/2015/186716.10.1155/2015/186716449937526221578
Search in Google Scholar Back to article
23. Sandesc M, Rogobete AF, Bedreag OH, et al. Analysis of oxidative stress-related markers in critically ill polytrauma patients: An observational prospective single-center study. Bosn J Basic Med Sci. 2018;18:191-197. doi: 10.17305/bjbms.2018.2306.10.17305/bjbms.2018.2306598853929310566
Search in Google Scholar Back to article
24. Magenta A, Cencioni C, Fasanaro P, et al. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ. 2011;18:1628-1639. doi: 10.1038/cdd.2011.42.10.1038/cdd.2011.42317212021527937
Open DOI Search in Google Scholar Back to article
25. Zaccagnini G, Martelli F, Fasanaro P, et al. p66 ShcA Modulates Tissue Response to Hindlimb Ischemia. Circulation. 2004;109:2917-2923. doi: 10.1161/01.CIR.0000129309.58874.0F.10.1161/01.CIR.0000129309.58874.0
Open DOI Search in Google Scholar Back to article
26. Lin Y, Liu X, Cheng Y, et al. Involvement of MicroRNAs in Hydrogen Peroxide-mediated Gene Regulation and Cellular Injury Response in Vascular Smooth Muscle Cells. J Biol Chem. 2009;284:7903-7913. doi: 10.1074/jbc.M806920200.10.1074/jbc.806920200
Open DOI Search in Google Scholar Back to article
27. Cybulsky MI, Iiyama K, Li H, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001;107:1209-1210. doi: 10.1172/JCI11871.10.1172/JCI1187120929811375415
Open DOI Search in Google Scholar Back to article
28. Lu J, Liu F, Liu D, et al. Amlodipine and atorvastatin improved hypertensive cardiac hypertrophy through regulation of receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B/osteoprotegerin system in spontaneous hypertension rats. Exp Biol Med. 2016;241:1237-1249. doi: 10.1177/1535370216630180.10.1177/1535370216630180495031226908571
Open DOI Search in Google Scholar Back to article
29. Bendaya I, Riahi A, Kharat M, et al. STAT1 and STAT6 Act as Antagonistic Regulators of PPAR γ in Diabetic Patients with and without Cardiovascular Diseases. Clin Lab. 2018;64:287-294. doi: 10.7754/Clin.Lab.2017.171013.10.7754/Clin..2017.171013
Open DOI Search in Google Scholar Back to article
30. Fehlmann T, Meese E, Keller A. Exploring ncRNAs in Alzheimer’s disease by miRMaster. Oncotarget. 2017;8:3771-3772. doi: 10.18632/oncotarget.14054.10.18632/oncotarget.14054535479328030833
Search in Google Scholar Back to article
31. Bedreag OH, Rogobete AF, Sandesc D, et al. Modulation of the Redox Expression and Inflammation Response in the Crtically Ill Polytrauma Patient with Thoracic Injury. Statistical Correlations between Antioxidant Therapy and Clinical Aspects. A Retrospective Single Center Study. Clin Lab. 2016;62:1747-1759. doi: 10.7754/Clin.Lab.2016.160206.10.7754/Clin..2016.160206
Open DOI Search in Google Scholar Back to article
32. Bratu LM, Rogobete AF, Papurica M, et al. Literature Research Regarding miRNAs’ Expression in the Assessment and Evaluation of the Critically Ill Polytrauma Patient with Traumatic Brain and Spinal Cord Injury. Clin Lab. 2016;62:2019-2024. doi: 10.7754/Clin.Lab.2016.160327.10.7754/Clin..2016.160327
Open DOI Search in Google Scholar Back to article
33. Dumache R, Ciocan V, Muresan C, Enache A. Molecular DNA Analysis in Forensic Identification. Clin Lab. 2016;62:245-248. doi: 10.7754/Clin.Lab.2015.150414.10.7754/Clin..2015.150414
Open DOI Search in Google Scholar Back to article
34. Cannino G, Di Liegro CM, Rinaldi AM. Nuclear-mitochondrial interaction. Mitochondrion. 2007;7:359-366. doi: 10.1016/j.mito.2007.07.001.10.1016/j.mito.2007.07.00117822963
Open DOI Search in Google Scholar Back to article
35. Karginov FV, Conaco C, Xuan Z, et al. A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A. 2007;104:19291-19296. doi: 10.1073/pnas.0709971104.10.1073/pnas.0709971104214828318042700
Open DOI Search in Google Scholar Back to article
36. Yang Z, Cappello T, Wang L. Emerging role of microRNAs in lipid metabolism. Acta Pharm Sin B. 2015;5:145-150. doi: 10.1016/j.apsb.2015.01.002.10.1016/j.apsb.2015.01.002462921526579440
Open DOI Search in Google Scholar Back to article
37. Pirtea L, Grigoraş D, Matusz P, et al. Human Papilloma Virus Persistence after Cone Excision in Women with Cervical High Grade Squamous Intraepithelial Lesion: A Prospective Study. Can J Infect Dis Med Microbiol. 2016;2016:3076380. doi: 10.1155/2016/3076380.10.1155/2016/3076380490456927366164
Open DOI Search in Google Scholar Back to article
38. Pirtea L, Grigoraş D, Matusz P, et al. Age and HPV type as risk factors for HPV persistence after loop excision in patients with high grade cervical lesions: an observational study. BMC Surg. 2016;16:1-7. doi: 10.1186/s12893-016-0185-7.10.1186/s12893-016-0185-7505313027716233
Open DOI Search in Google Scholar Back to article
39. Pirtea L, Raica M, Cimpean AM (2012) Endothelial cell activation and proliferation in ovarian tumors: Two distinct steps as potential markers for antiangiogenic therapy response. Mol Med Rep. 2012;5:1181-1184. doi: 10.3892/mmr.2012.812.10.3892/mmr.2012.81222378599
Open DOI Search in Google Scholar Back to article
40. Zhang X, Azhar G, Wei JY. The Expression of microRNA and microRNA Clusters in the Aging Heart. PLoS One. 2012;7:1-13. doi: 10.1371/journal.pone.0034688.10.1371/journal.pone.0034688332949322529925
Open DOI Search in Google Scholar Back to article
41. Dumache R, Ciocan V, Muresan C, et al. Circulating microRNAs as promising biomarkers in forensic body fluids identification. Clin Lab. 2015;61:1129-1135. doi: 10.7754/Clin.Lab.2015.150207.10.7754/Clin..2015.150207
Open DOI Search in Google Scholar Back to article
42. Dumache R, Muresan C, Ciocan V, et al. Post-Mortem Identification of a Fire Carbonized Body by STR Genotyping. Clin Lab. 2016;62:2033-2037. doi: 10.7754/Clin.Lab.2016.160417.10.7754/Clin..2016.160417
Open DOI Search in Google Scholar Back to article
43. Ticlea M, Melania L, Bodog F, Horea O. The Use of Exosomes as Biomarkers for Evaluating and Monitoring Critically Ill Polytrauma Patients with Sepsis. Biochem Genet. 2017;55:1-9. doi: 10.1007/s10528-016-9773-6.10.1007/s10528-016-9773-627612681
Open DOI Search in Google Scholar Back to article
44. Nitu R, Florin A, Gundogdu F, et al. microRNAs Expression as Novel Genetic Biomarker for Early Prediction and Continuous Monitoring in Pulmonary Cancer. Biochem Genet. 2017;55:281-290. doi: 10.1007/s10528-016-9789-y.10.1007/s10528-016-9789-y28070693
Open DOI Search in Google Scholar Back to article
45. Rogobete AF, Bedreag OH, Popovici SE, et al. Detection of Myocardial Injury Using miRNAs Expression as Genetic Biomarkers in Acute Cardiac Care. Journal of Cardiovascular Emergencies. 2016;2:169-172. doi: 10.1515/jce-2016-0025.10.1515/jce-2016-0025
Open DOI Search in Google Scholar Back to article
46. Papurica M, Rogobete AF, Sandesc D, et al. Using the Expression of Damage-Associated Molecular Pattern (DAMP) for the Evaluation and Monitoring of the Critically Ill Polytrauma Patient. Clin Lab. 2016;62:1829-1840. doi: 10.7754/Clin.Lab.2016.160226.10.7754/Clin..2016.160226
Open DOI Search in Google Scholar Back to article
47. Sandesc M, Dinu A, Rogobete AF, et al. Circulating microRNAs expressions as genetic biomarkers in pancreatic cancer patients continuous non-invasive monitoring. Clin Lab. 2017;63:1561-1566. doi: 10.7754/Clin.Lab.2017.170608.10.7754/Clin..2017.170608
Open DOI Search in Google Scholar Back to article
48. Negoita SI, Sandesc D, Rogobete AF, et al (2017) MiRNAs expressions and interaction with biological systems in patients with Alzheimer’s disease. Using miRNAs as a diagnosis and prognosis biomarker. Clin Lab. 2017;63:1315-1321. doi: 10.7754/Clin.Lab.2017.170327.10.7754/Clin..2017.170327
Open DOI Search in Google Scholar Back to article
49. Bratu LM, Rogobete AF, Papurica M, et al. Literature Research Regarding miRNAs’ Expression in the Assessment and Evaluation of the Critically Ill Polytrauma Patient with Traumatic Brain and Spinal Cord Injury. Clin Lab. 2016;62:2019-2024. doi: 10.7754/Clin.Lab.2016.160327.10.7754/Clin..2016.160327
Open DOI Search in Google Scholar Back to article
50. Bedreag OH, Sandesc D, Chiriac SD, et al. The Use of Circulating miRNAs as Biomarkers for Oxidative Stress in Critically Ill Polytrauma Patients. Clin Lab. 2016;62:263-274.doi: 10.7754/Clin.Lab.2015.150740.10.7754/Clin..2015.150740
Open DOI Search in Google Scholar Back to article
51. McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate genespecific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011;90:439-46. doi: 10.1189/jlb.0211075.10.1189/jlb.0211075315790121610199
Open DOI Search in Google Scholar Back to article
52. Olivieri F, Rippo MR, Prattichizzo F, et al. Toll like receptor signaling in “inflammaging”: microRNA as new players. Immun Ageing. 2013;10:11. doi: 10.1186/1742-4933-10-11.10.1186/1742-4933-10-11361818823506673
Open DOI Search in Google Scholar Back to article
53. Ucar A, Gupta SK, Fiedler J, et al. The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun. 2012;3:1078. doi: 10.1038/ncomms2090.10.1038/ncomms2090365799823011132
Open DOI Search in Google Scholar Back to article
54. Long G, Wang F, Duan Q, et al. Human Circulating MicroRNA-1 and MicroRNA-126 as Potential Novel Indicators for Acute Myocardial Infarction. Int J Biol Sci. 2012;8:811-888. doi: 10.7150/ijbs.4439.10.7150/ijbs.4439337288522719221
Search in Google Scholar Back to article
55. Greco S, Gorospe M, Martelli F. Noncoding RNA in age-related cardiovascular diseases. J Mol Cell Cardiol. 2015;83:142-155. doi: 10.1016/j.yjmcc.2015.01.011.10.1016/j.yjmcc.2015.01.011550946925640162
Open DOI Search in Google Scholar Back to article
56. Fichtlscherer S, Rosa S De, Fox H, et al. Circulating MicroRNAs in Patients With Coronary Artery Disease. Circ Res. 2010;107:677-684. doi: 10.1161/CIRCRESAHA.109.215566.10.1161/CIRCRESAHA.109.21556620595655
Open DOI Search in Google Scholar Back to article
57. Romaine SPR, Tomaszewski M, Condorelli G, Samani NJ. MicroRNAs in cardiovascular disease: An introduction for clinicians. Heart. 2015;101:921-928. doi: 10.1136/heartjnl-2013-305402.10.1136/heartjnl-2013-305402448426225814653
Open DOI Search in Google Scholar Back to article
58. Cheng Y, Tan N, Yang J, et al. A translational study of circulating cell-free microRNA-1 in acute myocardial infarction. 2010;95:87-95. doi: 10.1042/CS20090645.10.1042/CS20090645359381520218970
Open DOI Search in Google Scholar Back to article
59. Gidlöf O, Andersson P, Pals J Van Der, et al. Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be Detected in Urine Samples. Cardiology. 2011;118:217-226. doi: 10.1159/000328869.10.1159/00032886921701171
Open DOI Search in Google Scholar Back to article
60. Wang R, Li N, Zhang Y, et al. Circulating MicroRNAs are Promising Novel Biomarkers of Acute Myocardial Infarction. Intern Med. 2011;50:1789-1795. doi: 10.2169/internalmedicine.50.5129.10.2169/internalmedicine.50.512921881276
Open DOI Search in Google Scholar Back to article
61. Alessandra YD, Carena MC, Spazzafumo L, et al. Diagnostic Potential of Plasmatic MicroRNA Signatures in Stable and Unstable Angina. PLoS One. 2013;8:e80345. doi: 10.1371/journal.pone.0080345.10.1371/journal.pone.0080345382987824260372
Search in Google Scholar Back to article
62. Hoekstra M, van der Lans CAC, Halvorsen B, et al. The peripheral blood mononuclear cell microRNA signature of coronary artery disease. Biochem Biophys Res Commun. 2010;394:792-797. doi: https://doi.org/10.1016/j.bbrc.2010.03.075.10.1016/j.bbrc.2010.03.07520230787
Open DOI Search in Google Scholar Back to article
63. Tijsen AJ, Creemers EE, Moerland PD, et al. MiR423-5p as a circulating biomarker for heart failure. Circ Res. 2010;106:1035-1039. doi: 10.1161/CIRCRESAHA.110.218297.10.1161/CIRCRESAHA.110.21829720185794
Open DOI Search in Google Scholar Back to article
64. Caporali A, Meloni M, Vo C, et al. Deregulation of microRNA-503 Contributes to Diabetes Mellitus-Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia. Circulation. 2011;123:282-291. doi: 10.1161/CIRCULATIONAHA.110.952325.10.1161/CIRCULATIONAHA.110.95232521220732
Open DOI Search in Google Scholar Back to article
65. Liu C, Liu N, Cao B, et al. CircRNAs as Potential Biomarkers in Gastrointestinal Tract Tumors : Opportunities and Challenges. Clin Lab. 2018;64:141-145. doi: 10.7754/Clin.Lab.2017.170731.10.7754/Clin..2017.170731
Open DOI Search in Google Scholar Back to article
66. Giden R, Gökdemir MT, Erel Ö, et al. The Relationship Between Serum Thiol Levels and Thiol/Disulfide Homeostasis with Head Trauma in Children. Clin Lab. 2018;64:163-168. doi: 10.7754/Clin.Lab.2017.170816.10.7754/Clin..2017.170816
Open DOI Search in Google Scholar Back to article
67. Ma X, Buscaglia LEB, Barker JR, Li Y. MicroRNAs in NF-k B signaling. J Mol Cell Biol. 2011;3:159-166. doi: 10.1093/jmcb/mjr007.10.1093/jmcb/mjr007310401321502305
Open DOI Search in Google Scholar Back to article
68. Oeckinghaus A, Ghosh S. The NF-k B Family of Transcription Factors and Its Regulation. Cold Spring Harb Perspect Biol. 2009;1:a000034. doi: 10.1101/cshperspect.a000034.10.1101/cshperspect.a000034277361920066092
Open DOI Search in Google Scholar Back to article
69. Zhang H, Sun SC. NF‑κB in inflammation and renal diseases. Cell Biosci. 2015;5:63. doi: 10.1186/s13578-015-0056-4.10.1186/s13578-015-0056-4464771026579219
Open DOI Search in Google Scholar Back to article
70. Kleniewska P, Piechota-polanczyk A, Michalski L, et al. Influence of Block of NF-Kappa B Signaling Pathway on Oxidative Stress in the Liver Homogenates. Oxid Med Cell Longev. 2013;2013:308358. doi: 10.1155/2013/308358.10.1155/2013/308358361243923577221
Open DOI Search in Google Scholar Back to article
71. Hajra L, Evans AI, Chen M, et al. The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci U S A. 2000;97:9052-9057.10.1073/pnas.97.16.90521682010922059
Search in Google Scholar Back to article
72. Kanters E, Pasparakis M, Gijbels MJJ, et al. Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003;112:1176-1185. doi: 10.1172/JCI18580.10.1172/JCI1858021348814561702
Open DOI Search in Google Scholar Back to article
73. Yurdagul A, Sulzmaier FJ, Chen XL, et al. Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression. J Cell Sci. 2016;129:1580-1591. doi: 10.1242/jcs.182097.10.1242/jcs.182097485277126906414
Open DOI Search in Google Scholar Back to article
74. Meng Y, Chen C, Liu Y, et al. Angiotensin II Regulates Dendritic Cells through Activation of NF-κB/p65, ERK1/2 and STAT1 Pathways. Cell Physiol Biochem. 2017;42:1550-1558. doi: 10.1159/000479272.10.1159/00047927228723692
Open DOI Search in Google Scholar Back to article
75. Wang H, Wei Y, Zeng Y, et al. The association of polymorphisms of TLR4 and CD14 genes with susceptibility to sepsis in a Chinese population. BMC Med Genet. 2014;15:123. doi: 10.1186/s12881-014-0123-4.10.1186/s12881-014-0123-4441169625394369
Open DOI Search in Google Scholar Back to article
76. Ye E, Steinle JJ. miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNF-α to Protect Primary Human Retinal Microvascular Endothelial Cells Grown in High Glucose. Mediators of Inflammation. 2016;2016:3958453. https://doi.org/10.1155/2016/3958453.10.1155/2016/3958453477953926997759
Open DOI Search in Google Scholar Back to article

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

References

Paradigm

My account