Association between left ventricular function and patient outcomes
| Author (Year) | Objective | Measure of LV Function | Did LV Dysfunction Predict Outcomes? |
|---|---|---|---|
| Palmieri et al. (2015) | Assessed the prognostic relevance of EF and global longitudinal LV systolic peak strain in sepsis [21] | EF | No |
| GLS | Yes | ||
| Al Abbasi et al. (2020) | Assess gender-specific compliance with >30 mL/Kg fluid bolus and outcomes in patients with CHF [20] | EF | No* |
| Hai et al. (2020) | Evaluate the prognostic value of a LV systolic function using speckle tracking echocardiography in patients with septic shock [22] | Conventional 2D echo measures (EF, LVEDV, etc.) | No |
| GLS | Yes | ||
| Khan et al. (2020) | Assess the association between 30 mL/kg bolus and intubation in patients with sepsis or septic shock and HF, ESRD, or cirrhosis [12] | EF | No |
| Acharya et al. (2021) | Assess compliance with >30 mL/Kg fluid bolus in septic patients with and without CHF and their outcomes [7] | EF | Yes |
| Ehrman et al. (2022) | Assess the association between volume of IV crystalloid and outcomes in septic patients with reduced LVEF [19] | EF | No |
| Weng et al. (2024) | Assess the impact of early fluid dosing in septic patients with acute decompensated heart failure [16] | EF | Yes** |
Association between left ventricular dysfunction and fluid management
| Author (Year) | Objective | Key Findings | Did LV Dysfunction Predict Adherence to Fluid Bolus? |
|---|---|---|---|
| Franco Palacios CR et al. (2019) | Identify factors that affect fluid resuscitation in septic patients [5] | -LV function (EF or diastolic dysfunction) did not predict fluid volume administered, despite HF history being associated with less fluid given | No |
| Al Abbasi et al. (2020) | Assess gender-specific compliance with >30 mL/Kg fluid bolus and outcomes in patients with CHF [20] | -Women with HFpEF received higher volumes of fluid than men with HFpEF | No* |
| -Men and women with HFrEF received similar amounts of fluid | |||
| Acharya et al. (2021) | Assess compliance with >30 mL/Kg fluid bolus in septic patients with and without CHF and their outcomes [7] | -The presence of a reduced EF did not affect the chances of getting a fluid bolus. | No |
| Ehrman et al. (2022) | Assess the association between volume of IV crystalloid and outcomes in septic patients with reduced LVEF [19] | -HFrEF patients received similar IVF at 2h compared to preserved EF | No |
| Powell et al. (2022) | Assess compliance with >30 mL/kg bolus in septic HFrEF patients [6] | -HFrEF patients were less likely to receive IVF target at 6h compared to preserved EF | Yes |