Fig. 1.
Breakdown of Angioedema (AE) admission results with locations including the Intensive Care Unit (ICU) and non-ICU, as well as intubated and non-intubated status upon ICU admission.
Table 1.
Overall Patient Characteristics & Demographic, Non-ICU vs ICU
| Overall | Non-ICU | ICU | |
|---|---|---|---|
| Encounters | 135 | 85 | 50 |
| Patients | 117 | 69 | 48 |
| Demographics | |||
| Mean Age (years) | 58.5 | 56.0 | 61.9 |
| Sex | M, 63, 55% | M, 39 | M, 24 |
| F, 54, 45% | F, 30 | F, 24 | |
| Race | |||
| Black/AA | 89, 66% | 57 | 32 |
| White | 39, 29% | 25 | 14 |
| Other | 7, 5% | 3 | 4 |
| Etiology of AE | |||
| Unknown 63, 47% | Unknown, 48 | ACEi, 27 | |
| ACEi 51, 38% | ACEi, 26 | Unknown, 15 | |
| Other, 13, 10% | Other, 7 | Other, 6 | |
| Hereditary 6, 5% | Hereditary, 4 | Hereditary, 2 | |
| Mean LOS (days) | |||
| Total Hospital LOS | 1.43 2.9 | 0.31 0.69 | 3.37 |
| ICU LOS | -- | -- | 2.40 |
| Treatment | |||
| Histamine/corticosteroid/epinephrine regimen | 120, 78.5% | 72 | 48 |
| Biologic Agent (Icanibant) | 1, 1% | 1 | 0 |
| Other/No treatment | 14, 9.5% | 12 | 2 |
| Otolaryngology (ENT) | |||
| Had ENT Consult | 99, 73.3% | 50, 58% | 49, 98% |
Table 2.
ICU Population: Intubated vs Non-Intubated
| Overall | ICU Non-Intubated | ICU Intubated | |
|---|---|---|---|
| Encounters | 50 | 30 | 20 |
| Patients | 48 | 28 | 20 |
| Demographics | |||
| Mean Age (years) | 61.9 | 63.0 | 60.2 |
| Sex | M, 24, 50% | M, 12 | M, 12 |
| F, 24 | F, 16 | F, 8 | |
| Race | |||
| Black | 32 | 15 | 17 |
| White | 14 | 11 | 3 |
| Other | 4 | 4 | 0 |
| Etiology of AE | |||
| ACEi, 27 | ACEi, 17 | ACEi, 10 | |
| Unknown, 15 | Unknown, 9 | Unknown, 6 | |
| Other, 6 | Other, 3 | Other, 3 | |
| Hereditary, 2 | Hereditary, 1 | Hereditary, 1 | |
| Mean LOS (days) | |||
| Total Hospital LOS | 3.37 | 1.55 | 6.15 |
| ICU LOS | 2.40 | 1.10 | 4.35 |
| Comorbidities | |||
| Airway (OSA, COPD, Asthma) | 12 | 6 | 6 |
| Prior AE episodes or diagnosis of Hereditary AE | 11 | 8 | 3 |
Table 3.
Characteristics of Intubated Patients and Intubation Information
| Intubated Patients | Sex | Age | Race | Angioedema Etiology | Intubation Location | Intubation Timing from Presentation | Intubation rationale | Comorbidities/PMH |
|---|---|---|---|---|---|---|---|---|
| 1 | F | 57 | AA | ACE-I | ED | 2.75 | Dysarthria, tongue edema, floor of mouth edema | HTN, asthma, COPD, breast cancer |
| 2 | F | 77 | AA | ACE-I | ED | 1.5 | Diffuse edema | T2DM, HTN Obesity |
| 3 | M | 51 | AA | ACE-I | ED | 2 | Tongue edema, floor of mouth edema | T2DM |
| 4 | M | 63 | AA | ACE-I | ICU | 7 | Thickness of epiglottis, tongue edema, buccal mucosa edema | Prostate cancer, HTN |
| 5 | M | 37 | AA | ACE-I | ED | 1.3 | Tongue edema, floor of mouth edema, thickness of epiglottis | Obesity, CVA, HTN |
| 6 | M | 68 | AA | ACE-I | ED | 2 | Thickness of epiglottis | HF, AVr, COPD |
| 7 | F | 61 | W | HAE | ED | 3.25 | Diffuse edema, thickness of epiglottis, buccal mucosa edema | Hereditary Angioedema |
| 8 | F | 30 | AA | ACE-I | ICU | 7.5 | dysphagia, dysphonia, uvular swelling | HTN |
| 9 | F | 74 | AA | Methotrexate | ED | 0 | Dysphagia, diffuse edema, dysarthria | SLE, RA, GERD, HTN, DM, HLD, CAD, CKD, OSA, HFpEF |
| 10 | M | 48 | AA | Unk | OSH | 66* | Buccal mucosa edema | HF, CKD III, T2DM, COPD |
| 11 | M | 40 | AA | Unk | ED | 3 | Diffuse edema, intolerance of secretions, thickness of epiglottis | Angioedema, CVA, HTN, T2DM, HLD |
| 12 | F | 72 | AA | Unk | ICU | 1.5 | Diffuse edema | HTN, OSA, HAE, prior trach 2016 |
| 13 | M | 69 | W | Unk | ED | 1.25 | Diffuse edema, intolerance of secretions | ESRD, SUD, Angioedema |
| 14 | M | 67 | AA | Unk | OSH | 2.5 | Diffuse edema, dysarthria | HIV, COPD, Anal Cancer, T2DM, CKD, CAD |
| 15 | M | 68 | W | ACE-I | OSH | - | - | CABG, DM, HLD, Bladder cancer, HTN |
| 16 | F | 55 | AA | ACE-I | OSH | - | - | HTN, G6PD, HLD |
| 17 | M | 57 | AA | ACE-I | OSH | - | - | HTN, Seizures, Gout |
| 18 | M | 65 | AA | ACE-I | OSH | - | - | Renal Transplant, HTN, SUD |
| 19 | F | 84 | AA | Allergy | OSH | - | - | Dementia, HTN |
| 20 | M | 61 | AA | Unk | OSH | - | - | Angioedema, CVA, HTN, T2DM, HLD |
Fig. 2.
Figure describing patient demographics of the 20 intubations in our study, intubation location, and intubation timing and other data collected.
Figu. 3.
(Right) Average ICU Length of Stay in days compared between the ICU Non Intubated and ICU Intubated patient groups with * representing a p-value of <0.001. (Left) Average Hospital Length of Stay in days compared between all subset groups.