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The use of biomarkers testing in Emergency Department Cover

Figures & Tables

Demographic data of the responders

Number of answers = 168n (%)
Professional category:
Senior physician72 (42.9)
Junior physician41 (24.4)
5th year resident25 (14.9)
4th year resident30 (17.9)

Specialty:
Emergency Medicine160 (95.2)
Family Medicine3 (1.8)
Anaesthesia and Intensive Care0 (0)
Paediatrics4 (2.4)
Other specialty1 (0.6)

Professional experience (including residency):
1–5 years50 (29.8)
6–10 years40 (23.8)
11–15 years27 (16.1)
16–20 years21 (12.5)
21 years or more30 (17.9)

Gender
Male53 (31.5)
Female113 (67.3)
Prefer not to disclose2 (1.2)

Age
20–30 years27 (16.1)
31–40 years66 (39.3)
41–50 years51 (30.4)
51–60 years24 (14.3)

Type of emergency service
Emergency Department148 (88.1)
Emergency Reception Unit20 (11.9)

Type of work setting:
Public system164 (97.6)
Private system1 (0.6)
Both3 (1.8)

Type of hospital
County113 (67.3)
Municipal42 (25)
City3 (1.8)
Military Hospital4(2.4)
Other Hospital6 (3.6)

Is the hospital where you work a university hospital (involved in training residents/students)?
Yes141 (83.9)
No27 (16.1)

Reasons for not using biomarkers currently in clinical practice

Number of answers = 168n (%)
What are the biggest challenges you face in using biomarkers in your practice?
High cost of biomarker kits93 (55.4)
Limited availability (testing kits are not always available)70 (41.7)
False positive results63 (37.5)
The lack of specific guidelines49 (29.2)
Difficult interpretation of results9 (5.4)
Lengthy processing times7 (4.2)

Current practice

Number of answers = 168Likert scaleMedian (IQR)
How frequently do you use biomarkers in your daily practice?1 – 55 (4 – 5)

How often do you consider it necessary to use biomarkers other than those available in your hospital?1 – 53 (3 – 4)

What is the method for biomarker testing in the department where you work?1 – 5
  The hospital’s central laboratory
  The department’s own laboratory with Point of Care devices Both1 – 32 (2 – 3)

How frequently do you use point of care biomarkers?1 – 54 (4 – 5)

How often do you use biomarkers for the diagnosis of the following critical conditions?
  Acute myocardial infarction1 – 55 (5 – 5)
  Pulmonary embolism1 – 55 (4 – 5)
  Aortic dissection1 – 55 (4 – 5)
  Sepsis and septic shock1 – 55 (4 – 5)
  Acute heart failure1 – 54 (4 – 5)
  Cerebral hypoxia1 – 53 (1 – 5)
  Traumatic brain injury1 – 53 (1 – 4)
  Stroke1 – 53 (1 – 4)

Please rank the following biomarkers according to their utility in daily practice:
  Troponin1 – 55 (5 – 5)
  D-dimer1 – 55 (4 – 5)
  Brain natriuretic peptide or N-terminal pro b-type natriuretic peptide1 – 55 (4 – 5)
  Procalcitonin1 – 55 (4 – 5)
  C - reactive protein1 – 54 (4 – 5)
  Presepsin1 – 54 (3 – 5)
  Interleukin - 61 – 53 (2 – 4)

Advantages and emerging biomarker demands in ED

Number of answers = 168n (%)
Biomarkers are useful in:
Differential diagnosis145 (86.3)
Rapid diagnosis of a condition145 (86.3)
Enhancing the quality of medical care127 (75.6)
Assessing the severity of a condition108 (64.3)
Prognosis73 (43.5)
Avoiding the administration of unnecessary treatments72 (42.9)
Streamlining patient flow71 (42.3)

What is the method for biomarker testing in the department where you work?
The department’s own laboratory with Point of Care (POC) devices81 (48.2)
The hospital’s central laboratory12 (7.1)
Both75 (44.6)

Which biomarkers do you consider would be necessary to be introduced in your practice?
Neuron-Specific Enolase78 (46.4)
Interleukin - 670 (41.7)
Procalcitonin58 (34.5)
Presepsin43 (25.6)
S100B42 (25)
Brain natriuretic peptide (BNP)38 (22.6)
Resistin35 (20.8)
C - reactive protein33 (19.6)
D-dimer33 (19.6)
Troponin32 (19)
None of the above14 (8.3)
DOI: https://doi.org/10.2478/jccm-2024-0041 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 164 - 172
Submitted on: Sep 13, 2024
Accepted on: Oct 22, 2024
Published on: Apr 30, 2025
Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 Sonia Luka, Adela Golea, Raluca Mihaela Tat, Eugenia Maria Lupan Mureșan, George Teo Voicescu, Ștefan Cristian Vesa, Maria Adriana Albu, Daniela Ionescu, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.