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Neutrophil-to-Lymphocyte Ratio and Thrombocyte-to-Lymphocyte Ratio as a Predictor of Severe and Moderate/Mild Acute Respiratory Distress Syndrome Patients: Preliminary Results Cover

Neutrophil-to-Lymphocyte Ratio and Thrombocyte-to-Lymphocyte Ratio as a Predictor of Severe and Moderate/Mild Acute Respiratory Distress Syndrome Patients: Preliminary Results

Open Access
|Jan 2024

Figures & Tables

Fig. 1.

NLP differences between Severe ARDS and Mild/Moderate ARDS. NLR- Neutrophil-to-lymphocyte ratio; ARDS-acute respiratory distress syndrome; CI-confidence interval

Fig. 2.

PLR differences between Severe ARDS and Moderate/Milld ARDS. PLR- Platelets-to-lymphocyte ratio; ARDS- acute respiratory distress syndrome; CI-confidence interval

Fig. 3.

Comparison of NLR variations based on APACHE II score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation

Fig. 4.

Comparison of NLR variations based on SOFA2 score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval

Fig. 5.

Comparison of PLR variations based on SOFA score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval

Fig. 6.

Comparison between PLR variations based on APACHE II score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation; CI – Confidence interval

Fig. 7.

Investigation of NLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; NLR- Neutrophil-to-lymphocyte ratio; AUC-Area Under the Curve

Fig. 8.

Investigation of PLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; PLR- Platelets-tolymphocyte ratio; AUC-Area Under the Curve

Baseline characteristics

All patients (n=33)Severe ARDS (n=11)Mild/Moderate ARDS (n=22)P
Age (years, mean±SD)71.91±11.5470.73±13.6972.50±10.610.68*
GCS (median, min-max)8(3–15)6(3–15)8(3–15)0.69*
IOT-VM(n,%)26(78.78)9(81.81)17(77.27)0.76***
IOT-S(n,%)1(3.03)0(0)1(4.54)0.15***
NIV(n,%)1(3.03)0(0)1(4.54)0.15***
MF(n,%)5(15.15)2(18.18)3(13.63)0.73***
SpO2(%, mean±SD)95.97±5.4293.64±7.4397.14±3.770.40**
FiO2(%, mean±SD)68.94±20.6176.36±23.7865.23±18.290.16**
pH(mean±SD)7.306±0.147.304±0.137.315±0.140.83*
pO2(mmHg, mean±SD)91.68±40.4259.61±15.27107.7±39.63<0.0001**
pCO2(mmHg, mean±SD)50.65±20.5046.05±16.4752.95±22.250.44**
HCO3-(mEq/L, mean±SD)25.16±6.3522.12±5.2826.68±6.400.0491**
Leukocytes (cells/µL, mean±SD)15.91±7.5016.52±5.6615.60±8.380.7435*
Neutrophils (cells/µL, median, min-max)10.93(3.47–84.70)11.69(8.5–84.70)10.69(3.47–40.45)0.19**
Lymphocytes (cells/µL, median, min-max)0.7(0.15–8.24)0.6(0.15–8.24)0.71(0.2–7.09)0.55**
NLR(median, min-max)16.90(1.13–96)24.29(1.13–96)15.67(1.69–49.71)0.02*
PLR(median, min-max)315.8(0–1427)470.3(30.83–1427)252.1(0–1253)0.049**
APACHE II Score(mean±SD)26.42±5.1426.30±7.51426.48±3.770.93*
SOFA (mean±SD)10.33±3.2210.55±3.44610.23±3.190.79**
Outcome(n,%)29(87.87)10(90.90)19(86.36)0.70***
DOI: https://doi.org/10.2478/jccm-2024-0005 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 49 - 55
Submitted on: Jul 1, 2023
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Accepted on: Dec 8, 2023
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Published on: Jan 30, 2024
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2024 Mihai Claudiu Pui, Mihaela Butiulca, Vlad Cehan, Florin Stoica, Alexandra Lazar, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.