Table 1.
Baseline characteristics
| All patients (n=33) | Severe ARDS (n=11) | Mild/Moderate ARDS (n=22) | P | |
|---|---|---|---|---|
| Age (years, mean±SD) | 71.91±11.54 | 70.73±13.69 | 72.50±10.61 | 0.68* |
| GCS (median, min-max) | 8(3–15) | 6(3–15) | 8(3–15) | 0.69* |
| IOT-VM(n,%) | 26(78.78) | 9(81.81) | 17(77.27) | 0.76*** |
| IOT-S(n,%) | 1(3.03) | 0(0) | 1(4.54) | 0.15*** |
| NIV(n,%) | 1(3.03) | 0(0) | 1(4.54) | 0.15*** |
| MF(n,%) | 5(15.15) | 2(18.18) | 3(13.63) | 0.73*** |
| SpO2(%, mean±SD) | 95.97±5.42 | 93.64±7.43 | 97.14±3.77 | 0.40** |
| FiO2(%, mean±SD) | 68.94±20.61 | 76.36±23.78 | 65.23±18.29 | 0.16** |
| pH(mean±SD) | 7.306±0.14 | 7.304±0.13 | 7.315±0.14 | 0.83* |
| pO2(mmHg, mean±SD) | 91.68±40.42 | 59.61±15.27 | 107.7±39.63 | <0.0001** |
| pCO2(mmHg, mean±SD) | 50.65±20.50 | 46.05±16.47 | 52.95±22.25 | 0.44** |
| HCO3-(mEq/L, mean±SD) | 25.16±6.35 | 22.12±5.28 | 26.68±6.40 | 0.0491** |
| Leukocytes (cells/µL, mean±SD) | 15.91±7.50 | 16.52±5.66 | 15.60±8.38 | 0.7435* |
| Neutrophils (cells/µL, median, min-max) | 10.93(3.47–84.70) | 11.69(8.5–84.70) | 10.69(3.47–40.45) | 0.19** |
| Lymphocytes (cells/µL, median, min-max) | 0.7(0.15–8.24) | 0.6(0.15–8.24) | 0.71(0.2–7.09) | 0.55** |
| NLR(median, min-max) | 16.90(1.13–96) | 24.29(1.13–96) | 15.67(1.69–49.71) | 0.02* |
| PLR(median, min-max) | 315.8(0–1427) | 470.3(30.83–1427) | 252.1(0–1253) | 0.049** |
| APACHE II Score(mean±SD) | 26.42±5.14 | 26.30±7.514 | 26.48±3.77 | 0.93* |
| SOFA (mean±SD) | 10.33±3.22 | 10.55±3.446 | 10.23±3.19 | 0.79** |
| Outcome(n,%) | 29(87.87) | 10(90.90) | 19(86.36) | 0.70*** |
Abbreviations: ARDS-acute respiratory distress syndrome; NLR = Neutrophile Lymphocyte Ratio; PLR = Platelets Lymphocyte Ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation; SOFA - The Sequential Organ Failure Assessment; GCS = Glasgow Coma Scale; MF= Facial mask; NIV= non invasive ventilation; IOT-S= tracheal intubation with T-piece; IOT-VM= tracheal intubation mechanical ventilated; SpO2=oxygen saturation; FiO2=inspiratory oxygen fraction; pO2=partial pressure of oxygen; pCO2=partial pressure of carbon dioxide; HCO3=bicarbonate;
Fig. 1.
NLP differences between Severe ARDS and Mild/Moderate ARDS. NLR- Neutrophil-to-lymphocyte ratio; ARDS-acute respiratory distress syndrome; CI-confidence interval
Fig. 2.
PLR differences between Severe ARDS and Moderate/Milld ARDS. PLR- Platelets-to-lymphocyte ratio; ARDS- acute respiratory distress syndrome; CI-confidence interval
Fig. 3.
Comparison of NLR variations based on APACHE II score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation
Fig. 4.
Comparison of NLR variations based on SOFA2 score: below and above mean score analysis. NLR- Neutrophil-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval
Fig. 5.
Comparison of PLR variations based on SOFA score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; SOFA - The Sequential Organ Failure Assessment; CI – Confidence interval
Fig. 6.
Comparison between PLR variations based on APACHE II score: below and above mean score analysis. PLR- Platelets-to-lymphocyte ratio; APACHE II - The Acute Physiology and Chronic Health Evaluation; CI – Confidence interval
Fig. 7.
Investigation of NLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; NLR- Neutrophil-to-lymphocyte ratio; AUC-Area Under the Curve
Fig. 8.
Investigation of PLR cutoff value based on ARDS severity: ROC curve analysis. ROC-Receiver Operating Characteristic; PLR- Platelets-tolymphocyte ratio; AUC-Area Under the Curve