Thyroid hormone results of COPD patients with acute hypercapnic respiratory failure
| Parameters | N (%) |
|---|---|
| Normal thyroid hormone levels | 29 (36.3) |
| Non-thyroidal illness syndrome | |
| Low fT3 | 17 (21.2) |
| Low fT4 | 14 (17.5) |
| Low TSH | 4 (5) |
| Low fT3 and fT4 | 8 (10) |
| Low TSH and fT3 | 3 (3.7) |
| Low TSH and fT4 | 4 (5) |
| Low TSH, fT3 and fT4 | 1 (1.3) |
| Total | 80 (100%) |
A comparison of acute hypercapnic respiratory failure COPD patients with and without low thyroid hormone levels
| Parameters | TSH | fT4 | fT3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ≥0.3 IU/mL (N = 68) | <0.3 IU/mL (N = 12) | P | ≥0.93 ng/dL (N = 53) | <0.93 ng/dL (N = 27) | P | ≥2 pg/mL (N = 51) | <2 pg/mL (N = 29) | P | |
| Age, years | 70.9 ± 9.6 | 75.3 ± 8.3 | 0.119 | 71.9 ± 8.9 | 70.7 ± 10.7 | 0.618 | 71.5 ± 7.0 | 71.7 ± 10.3 | 0.936 |
| Male, n (%) | 39 (57.4) | 7 (58.3) | 0.949 | 28 (52.8) | 18 (66.7) | 0.236 | 31 (60.8) | 5 (51.7) | 0.431 |
| HT, n (%) | 42 (61.8) | 8 (66.7) | 0.746 | 35 (66.0) | 15 (55.6) | 0.360 | 30 (58.8) | 20 (69) | 0.368 |
| DM, n (%) | 21 (30.9) | 2 (16.7) | 0.493 | 18 (34.0) | 5 (18.5) | 0.195 | 17 (33.3) | 6 (20.7) | 0.230 |
| CVD, n (%)† | 39 (57.4) | 6 (50.0) | 0.755 | 33 (62.3) | 12 (44.4) | 0.156 | 31 (60.8) | 14 (48.3) | 0.278 |
| Long-term O2 use, n (%) | 31 (45.6) | 9 (75.0) | 0.060 | 28 (52.8) | 12 (44.4) | 0.637 | 25 (49.0) | 15 (51.7) | 0.816 |
| Admission from wards, n (%)‡ | 35 (51.5) | 7 (58.3) | 0.611 | 26 (49.1) | 16 (59.3) | 0.480 | 22 (43.1) | 20 (69.0) | 0.026 |
| APACHE II | 22.7 ± 7.5 | 23.3 ± 7.3 | 0.816 | 23.0 ± 7.2 | 23.4 ± 8.0 | 0.632 | 20.9 ± 7.0 | 26.1 ± 7.1 | 0.002 |
| GCS | 11.9 ± 3.7 | 9.0 ± 4.2 | 0.042 | 11.6 ± 3.7 | 11.1 ± 4.3 | 0.570 | 11.9 ± 3.7 | 10.7 ± 4.1 | 0.184 |
| IMV, n (%) | 30 (44.1) | 5 (41.7) | 0.875 | 22 (41.5) | 13 (48.1) | 0.710 | 19 (37,3) | 16 (55.2) | 0.120 |
| Vasopressor, n (%) | 25 (36.3) | 3 (25) | 0.912 | 19 (35.9) | 9 (33.3) | 0.823 | 12 (23.5) | 16 (55.2) | 0.004 |
| Albumin, g/dL | 3.3 ± 0.5 | 3.2 ± 0.6 | 0.590 | 3.3 ± 0.5 | 3.1 ± 0.6 | 0.209 | 3.4 ± 0.5 | 3.0±0.5 | 0.059 |
| Creatinine, mg/dL | 1.4 ± 1.4 | 1.3 ± 0.7 | 0.691 | 1.4 ± 1.1 | 1.4 ± 1.4 | 0.660 | 1.3 ± 1.1 | 1.5 ± 1.4 | 0.473 |
| CRP, mg/dL | 7.6 (2–13) | 7.9 (1.5–18) | 0.740 | 8 (2–17) | 10 (1–13) | 0.791 | 5.5 (1–12) | 11 (4.6–16) | 0.010 |
| WBC ×103/L | 14 ± 7.5 | 13.3 ± 4.8 | 0.668 | 13.8 ± 6.7 | 14.1 ± 8.1 | 0.887 | 12.6 ± 5.0 | 16.2 ± 9.5 | 0.027 |
| pH | 7.26 ± 0.08 | 7.29 ± 0.07 | 0.108 | 7.28 ± 0.05 | 7.25 ± 0.10 | 0.085 | 7.28 ± 0.07 | 7.25 ± 0.08 | 0.102 |
| PCO2, mm Hg | 66 ± 17.4 | 62.8 ± 14.9 | 0.514 | 65.5 ± 16.4 | 65.6 ± 18.4 | 0.996 | 64 ± 18 | 68.0 ± 15.0 | 0.360 |
| HCO3, mEq/L | 25.3 ± 5.5 | 27.1 ± 6.0 | 0.376 | 26.2 ± 4.8 | 24.4 ± 6.7 | 0.178 | 25.6 ± 5.0 | 25.5 ± 6.6 | 0.920 |
| PaO2/FiO2, mm Hg | 215±92 | 192 ± 93 | 0.448 | 205 ± 92 | 223 ± 93 | 0.429 | 224 ± 95 | 190 ± 84 | 0.100 |
| ICU LOS, days | 6 (4–10.3) | 5 (4–9) | 0.554 | 6 (4–10.5) | 5 (4–9) | 0.561 | 5 (4–7) | 8 (4–20) | 0.021 |
| Hospital LOS, days | 10 (6–15.3) | 11 (6–20.5) | 0.765 | 11 (7.5–15.5) | 10 (6–16) | 0.415 | 9 (6–14) | 11 (9–23) | 0.142 |
| In-hospital mortality, n (%) | 19 (27.9) | 4 (33.3) | 0.206 | 16 (30.2) | 7 (25.9) | 0.797 | 9 (17.6) | 14 (48.3) | 0.004 |
Univariate and multivariate logistic regression analyses for estimating in-hospital mortality
| Parameters | Univariate† | Multivariate‡ | ||||
|---|---|---|---|---|---|---|
| P | OR | 95% CI | P | OR | 95% CI | |
| fT3 | 0.001 | 0.172 | 0.062–0.473 | 0.027 | 0.271 | 0.085–0.865 |
| IMV | 0.001 | 6.139 | 2.073–18.175 | |||
| Albumin | <0.001 | 0.094 | 0.026–0.344 | |||
| Creatinine | 0.063 | 1.490 | 0.979–2.270 | |||
| CRP | 0.041 | 1.048 | 1.002–1.097 | |||
| WBC | 0.044 | 1.072 | 1.002–1.147 | |||
| APACHE II | <0.001 | 1.210 | 1.099–1.334 | 0.007 | 1.155 | 1.041–1.282 |
| GCS | 0.043 | 0.880 | 0.777–0.996 | |||
| Vasopressor | <0.001 | 11.848 | 3.790–37.037 | 0.013 | 5.426 | 0.439–20.468 |
| Admission from the ward | 0.056 | 2.725 | 0.973–7.632 | |||
A comparison of acute hypercapnic respiratory failure COPD patients with and without non-thyroidal illness syndrome
| Parameters | NTIS (−) (N = 29) | NTIS (+) (N = 51) | p |
|---|---|---|---|
| Age, years | 70.5 ± 7.3 | 71.2 ± 9.5 | 0.445 |
| Male, n (%) | 17 (58.6) | 29 (56.9) | 0.878 |
| HT, n (%) | 18 (62.1) | 32 (62.7) | 0.952 |
| DM, n (%) | 11 (37.9) | 12 (23.5) | 0.171 |
| CVD, n (%)† | 24 (82,8) | 35 (68.6) | 0.167 |
| Long-term O2 use, n (%) | 14 (48.3) | 26 (51.0) | 0.816 |
| Admission from wards, n (%)‡ | 12 (41.4) | 30 (58.8) | 0.133 |
| APACHE II | 21.7 ± 7.0 | 23.4 ± 7.7 | 0.295 |
| GCS | 11.6 ± 3.8 | 11.4 ± 4.1 | 0.829 |
| IMV, n (%) | 13 (44.8) | 22 (43.1) | 0.884 |
| Vasopressor, n (%) | 8 (27.6) | 20 (39.2) | 0.294 |
| Albumin, g/dL | 3.5 ± 0.5 | 3.1 ± 0.5 | 0.011 |
| Creatinine, mg/dL | 1.5 ± 1.3 | 1.3 ± 1.4 | 0.635 |
| CRP, mg/dL | 6.2 (1.6–12) | 9.7 (1.9–14.8) | 0.519 |
| WBC, ×103/L | 11.1 ± 3.2 | 13.4 ± 7.0 | 0.044 |
| pH | 7.28 ± 0.06 | 7.26 ± 0.09 | 0.392 |
| PCO2, mm Hg | 64.0 ± 17.1 | 66.2 ± 17.0 | 0.545 |
| HCO3, mEq/L | 25.5 ± 4.6 | 25.7 ± 6.1 | 0.886 |
| PaO2/FiO2, mm Hg | 227 ± 97 | 202 ± 88 | 0.251 |
| ICU LOS, days | 6 (4–10.5) | 5 (4–10) | 0.693 |
| Hospital LOS, days | 12 (7.5–14.5) | 10 (6–16) | 0.634 |
| In-hospital mortality, n (%) | 4 (13.8) | 19 (37.3) | 0.022 |