Characteristics of participants according to weaning outcome_
| Weaning Success (N=61) | Weaning Failure (N=97) | P Value | |
|---|---|---|---|
| Age, years | 62.39 (59.1–65.66) | 67.41 (65.22–69.61) | 0.02 |
| Men, n (%) | 42 (68.9) | 61 (62.96) | 0.49 |
| APACHE II score Day 0 | 14.87 (13.46–16.28) | 16.46 (15.19–17.72) | 0.12 |
| SOFA score Day 0 | 7.2 (6.67–7.75) | 8.24 (7.70–8.77) | 0.02 |
| Heart failure, n (%) | 4 (6.5) | 18 (18.5) | 0.03 |
| Diabetes mellitus, n (%) | 13 (21.3) | 14 (14.4) | 0.28 |
| Hypertension, n (%) | 31 (50.8) | 46 (47.4) | 0.74 |
| COPD, n (%) | 4 (6.5) | 20 (20.6) | 0.02 |
| Immunosuppression, n (%) | 2 (3.2) | 12 (12.3) | 0.08 |
| Corticosteroids, mg/Kg/Daya | 0.95 (0.65–1.26) | 0.93 (0.69–1.18) | 0.66 |
| PO2/FiO2, mmHg | 142.9 (123.2–162.5) | 124.9 (97.89–151.9) | 0.25 |
| Mechanical ventilation duration, days | 7.6 (6.1–9.07) | 12.9 (11.06–14.73) | <0.0001 |
| Vt ml/Kgb | 5.80 (5.30–6.30) | 6.26 (6.02–6.51) | 0.058 |
| Pplat, ICU Day 0, cmH2O | 22.85 (21.52–24.18) | 25.28 (23.89–26.66) | 0.04 |
| Driving Pressure, ICU Day 0, cm H2O | 11.1 (10.3–11.9) | 13.02 (11.84–14.21) | 0.03 |
| PEEP ICU Day 0, cmH2O | 10.54 (9.65–11.42) | 10.21 (9.52–10.90) | 0.38 |
| PEEP >12 cmH2O (Day 0–7), hours | 43.53 (28.02–59.03) | 55.11 (41.30–68.92) | 0.28 |
| Fluid Balance ICU Days 0–7, lit | 3.44 (1.17–5.71) | 6.17 (4.2–8.13) | 0.04 |
| SARS-CoV-2 pneumonia, n (%) | 42 (68.8) | 54 (55.7) | 0.13 |
| Temperature >38.5 °C, hours | 21.34 (10.99–31.70) | 28.19 (16.70–39.69) | 0.56 |
| VAP, n (%) | 29 (47.5) | 33 (34) | 0.09 |
| VAPc | 153 (17.31) | 191 (21.61) | <0.0001 |
| BSI, n (%) | 22 (36) | 46 (47.4) | 0.18 |
| BSId | 116 (13.11) | 266 (30.06) | 0.001 |
| Shock, n (%) | 20 (32.7) | 59 (60.8) | 0.001 |
| Septic – VAP, n (%) | 4 (20) | 5 (8.5) | |
| Septic – BSI, n (%) | 6 (30) | 16 (27.1) | |
| Septic – VAP&BSI, n (%) | 6 (30) | 15 (25.4) | |
| Unclear*, n (%) | 3 (15) | 24 (40.7) | |
| ICU antibiotics course, dayse | 18.56 (15.78–21.34) | 16.55 (14.25–18.84) | 0.13 |
| ICU mortality 28th day, n (%) | 6 (9.8) | 67 (69) | <0.0001 |
| ICU length of stay, days | 18.87 (16.17–21.56) | 17.25 (14.89–19.61) | 0.12 |
Characteristics of SARS-CoV2 ARDS patients according to weaning outcome_
| Weaning Success (N=42) | Weaning Failure (N=54) | P Value | |
|---|---|---|---|
| Age, years | 61.26 (57.12–65.41) | 68.98 (65.89–72.08) | 0.003 |
| Men, n (%) | 28(66.7) | 33(61.1) | 0.67 |
| APACHE II score ICU Day 0 | 14.38 (12.95–15.81) | 15.69 (14.34–17.03) | 0.15 |
| SOFA score ICU Day 0 | 7.4 (6.80–8.09) | 8.2 (7.56–8.84) | 0.16 |
| Heart failure, n (%) | 2 (4.7) | 7 (12.3) | 0.29 |
| Diabetes mellitus, n (%) | 9 (21.4) | 17 (31.5) | 0.35 |
| Hypertension, n (%) | 20 (47.6) | 27 (50) | 0.84 |
| COPD, n (%) | 2 (4.8) | 11 (20.4) | 0.03 |
| Immunosuppression, n (%) | 0 (0.0) | 6 (11.1) | 0.03 |
| Corticosteroids, mg/kg/Daya | 1.13 (0.77–1.49) | 1.43 (1.07–1.80) | 0.29 |
| PO2/FiO2, mmHg | 148.9 (123.8–174) | 106.1 (75.68–136.5) | 0.02 |
| Mechanical ventilation duration, days | 7.59 (5.91–9.27) | 11.56 (9.17–13.92) | 0.006 |
| Vt ml/Kgb | 5.80 (5.27–6.34) | 6.39 (6.18–6.11) | 0.13 |
| Pplat, ICU Day 0, cmH2O | 22.67 (21.23–24.1) | 25.37 (23.91–26.88) | 0.016 |
| Driving Pressure, ICU Day 0, cm H2O | 10.92 (10.11–11.72) | 13.02 (11.84–14.21) | 0.017 |
| PEEP ICU Day 0, cmH2O | 11.45 (10.39–12.51) | 11.94 (11.13–12.76) | 0.63 |
| PEEP >12 cmH2O (Day 0–7), hours | 61.5 (41.83–81.17) | 82.17 (62.55–101.7) | 0.11 |
| Fluid Balance ICU Days 0–7, lit | 2.71 (−0.1–5.51) | 3.74 (1.17–5.80) | 0.3 |
| Temperature >38.5°C, hours | 22.36 (10.88–33.83) | 14.56 (4.61–24.50) | 0.14 |
| VAP, n (%) | 22 (53.6) | 15 (27.8) | 0.01 |
| VAPc | 126 (19.35) | 110 (16.90) | <0.0001 |
| BSI, n (%) | 15 (36.6) | 25 (46.3) | 0.4 |
| BSId | 86 (13.23) | 183 (28.15) | 0.02 |
| Shock, n (%) | 12 (29.2) | 39 (72.2) | <0.0001 |
| VAP, n (%) | 3 (25) | 4 (10.2) | |
| BSI, n (%) | 2 (16.6) | 11 (28.2) | |
| VAP and BSI, n (%) | 5 (41.6) | 8 (20.5) | |
| Unclear*, n (%) | 2 (16.6) | 15 (38.4) | |
| ICU antibiotics course, dayse | 16.5 (13.86–19.14) | 13.13 (10.60–15.66) | 0.02 |
| ICU mortality 28th day, n (%) | 4 (9.7) | 42 (77.8) | <0.0001 |
| ICU length of stay, days | 17.44 (14.87–20) | 13.65 (11.18–16.12) | 0.01 |
Results of binary regression analyses of risk factors associated with weaning success in SARS-CoV2 ARDS patients and ARDS patients
| Variables | S.E | P value | O.R | Lower 95% C.I | Upper 95% C.I |
|---|---|---|---|---|---|
| SARS-CoV2 ARDS | |||||
| COPD | 0.85 | 0.04 | 0.18 | 0.03 | 0.96 |
| SOFA score | 0.11 | 0.17 | 0.86 | 0.69 | 1.06 |
| Shock | 0.49 | 0.02 | 0.33 | 0.12 | 0.86 |
| ARDS | |||||
| COPD | 0.86 | 0.36 | 0.46 | 0.08 | 2.44 |
| SOFA score | 0.11 | 0.07 | 0.82 | 0.66 | 1.01 |
| Shock | 0.59 | 0.71 | 0.8 | 0.25 | 2.55 |
Results of binary regression analysis of risk factors associated with weaning success in the total population
| Variables | S.E | P value | O.R | Lower 95%C.I | Upper 95% C.I |
|---|---|---|---|---|---|
| COPD | 0.61 | 0.03 | 0.27 | 0.08 | 0.89 |
| SOFA score | 0.08 | 0.04 | 0.86 | 0.73 | 0.99 |
| Shock | 0.37 | 0.001 | 0.3 | 0.14 | 0.61 |