Fig. 1.
Fig. 2.
Fig. 3.
Characteristics of Included Studies
| Study | Mild Hypothermia | Standard of Care | Initial Shockable Rhythm | Out-of-Hospital Arrest | Median Time to ROSC | Bystander CPR | Duration of Cooling | Surface Cooling |
|---|---|---|---|---|---|---|---|---|
| Bernard. HACA. 2002. | 32 to 34 | Normothermia | 96% | 87% | 22 | 46% | 24 | 100% |
| Bernard. OHCA. 2002. | 33 | Normothermia | 100% | 100% | 26 | 58% | 18 | 100% |
| Nielsen. TTM. 2013. | 33 | 36 | 80% | 100% | 25 | 73% | 28 | 76% |
| Lascarrou. HY PERION. 2019. | 33 | 37 | 0% | 73% | NR | 70% | 24 | 85% |
| Dankiewicz. TTM2. 2021. | 33 | 37.5 | 74% | 100% | 25 | 80% | 28 | 70% |
Absolute Percentages of Adverse Effects at the Participant Levela
| Adverse Effect | Hypothermia | Normothermia | Absolute Difference | Fragility Indexb |
|---|---|---|---|---|
| Arrhythmias | 306/1389(22%) | 227/1390 (16.3%) | 5.7% | 38 |
| Bleeding | 95/1389 (6.8%) | 89/1391 (6.4%) | 0.4% | 0 |
| Seizures | 77/463 (16.6%) | 83/464 (17.9%) | −1.3% | 0 |
| Infection | 593/1388 (42.7%) | 544/1391 (39.1%) | 3.6% | 0 |