Fig. 1.
Fig. 2.
Fig. 3.
Severity scores on admission, ogan support parameters and biochemical test values at key stages throughout ICU admission
| Test | Admission | Day 7 | Day 17: HSV-1 Positive | Day 28: Completion of Acyclovir | Day 49: ICU Discharge | |
|---|---|---|---|---|---|---|
| Severity Score | MODS | 8 | N/A | N/A | N/A | N/A |
| SOFA | 8 | N/A | N/A | N/A | N/A | |
| APACHE-II | 14 | N/A | N/A | N/A | N/A | |
| Respiratory Support | FiO2 (%) | 60 | 35 | 70 | 35 | 21 |
| PEEP (cmH20) | 16 | 16 | 15 | 8 | N/A | |
| Pressure Support (cmH20) | N/A | N/A | N/A | 15 | N/A | |
| Mode of Ventilation | Volume Control | Volume Control | Volume Control | Pressure Support | No Support | |
| Cardiovascular Support | Noradrenaline dose (mcg/kg/hour) | 0 | 0 | 0.03 | 0 | 0 |
| Renal Support | Filtration Rate (ml/kg/hr) | 0 | 0 | 25 | 0 | 0 |
| Laboratory Findings | Hb (g/L) | 142 | 108 | 100 | 90 | 110 |
| PLT (×109/L) | 209 | 216 | 171 | 231 | 237 | |
| WCC (×109/L) | 8.2 | 5.4 | 10.3 | 10.1 | 7.5 | |
| Neutrophils (×109/L) | 7.3 | 3.9 | 7.1 | 7.4 | 4.7 | |
| Lymphocytes(×109/L) | 0.6 | 1.3 | 2 | 1.7 | 2.3 | |
| PT (seconds) | 12.9 | 13.4 | 14.3 | 15.9 | N/A | |
| APTT (seconds) | 28.9 | 23.6 | 29.7 | 31.1 | N/A | |
| INR | 1.0 | 1.1 | 1.1 | 1.1 | N/A | |
| Urea (mmol/L) | 3.4 | 11 | 11.7 | 5.6 | 3.3 | |
| Creatinine (μmol/L) | 67 | 57 | 101 | 47 | 48 | |
| eGFR (ml/min/1.73m2) | >90 | >90 | 58 | >90 | >90 | |
| Na+ (mmol/L) | 136 | 143 | 144 | 141 | 137 | |
| K+ (mmol/L) | 4.2 | 4 | 4.2 | 4.1 | 3.1 | |
| ALT (iu/L) | 53 | 73 | 44 | 33 | 29 | |
| ALP (iu/L) | 58 | 47 | 64 | 61 | 63 | |
| Bilirubin (μmol/L) | 9 | 10 | 14 | 10 | 8 | |
| Albumin (g/L) | 39 | 31 | 31 | 30 | 34 | |
| CRP | 63 | 8 | 121 | 37 | 11 | |
| pH | 7.4 | 7.54 | 7.41 | 7.45 | N/A | |
| Lactate (mmol/L) | 1.6 | 1.8 | 1.7 | 1.6 | N/A | |
| pO2 (kPa) | 9.7 | 8.7 | 12.6 | 8.7 | N/A | |
| pCO2 (kPa) | 5.7 | 6.4 | 8.3 | 5.1 | N/A |