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Early Lactate Clearance as a Determinant of Survival in Patients with Sepsis: Findings from a Low-resource Country

Open Access
|Feb 2023

References

  1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definition for sepsis and septic shock (Sepsis-3). Jama. 2016;315(8):801-10.
  2. Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet. 2020;395(10219):200-11.
  3. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. American journal of respiratory and critical care medicine. 2016;193(3):259-72.
  4. Phua J, Koh Y, Du B, Tang Y-Q, Divatia JV, Tan CC, et al. Management of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study. BMJ. 2011;342.
  5. Previsdomini M, Gini M, Cerutti B, Dolina M, Perren A. Predictors of positive blood cultures in critically ill patients: a retrospective evaluation. Croatian medical journal. 2012;53(1):30-9.
  6. Khan DA, Rahman A, Khan FA. Is procalcitonin better than C‐ reactive protein for early diagnosis of bacterial pneumonia in children? Journal of clinical laboratory analysis. 2010;24(1):1-5.
  7. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving sepsis campaign: international guidelines for the management of sepsis and septic shock: 2016. Intensive care medicine. 2017;43(3):304-77.
  8. Casserly B, Phillips GS, Schorr C, Dellinger RP, Townsend SR, Osborn TM, et al. Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Critical care medicine. 2015;43(3):567-73.
  9. Sterling SA, Puskarich MA, Shapiro NI, Trzeciak S, Kline JA, Summers RL, et al. Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock. Shock (Augusta, Ga). 2013;40(1):11.
  10. Howell MD, Donnino M, Clardy P, Talmor D, Shapiro NI. Occult hypoperfusion and mortality in patients with suspected infection. Intensive care medicine. 2007;33(11):1892-9.
  11. Kruse JA, Zaidi SA, Carlson RW. Significance of blood lactate levels in critically III patients with liver disease. The American journal of medicine. 1987;83(1):77-82.
  12. Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Critical care medicine. 2009;37(5):1670-7.
  13. Ryoo SM, Lee J, Lee Y-S, Lee JH, Lim KS, Huh JW, et al. Lactate level versus lactate clearance for predicting mortality in patients with septic shock defined by sepsis-3. Critical care medicine. 2018;46(6):e489-e95.
  14. Bruno RR, Wernly B, Binneboessel S, Baldia P, Duse DA, Erkens R, et al. Failure of Lactate Clearance Predicts the Outcome of Critically Ill Septic Patients. Diagnostics. 2020;10(12):1105.
  15. Nguyen HB, Rivers EP, Knoblich BP, Jacobsen G, Muzzin A, Ressler JA, et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Critical care medicine. 2004;32(8):1637-42.
  16. Innocenti F, Meo F, Giacomelli I, Tozzi C, Ralli ML, Donnini C, et al. Prognostic value of serial lactate levels in septic patients with and without shock. Internal and emergency medicine. 2019;14(8):1321-30.
  17. Taniguchi T, Sato K, Okajima M. Procalcitonin and lactate clearances as markers of improvement of severity in abdominal septic shock. Critical Care Medicine. 2018;46(1):704.
  18. Takahashi N, Nakada T-a, Walley KR, Russell JA. Significance of lactate clearance in septic shock patients with high bilirubin levels. Scientific reports. 2021;11(1):1-9.
  19. Moustafa AA, Antonios MA, Abdellatif EM, Hussain AH. Association of lactate/albumin ratio level to organ failure and mortality in severe sepsis in a pediatric intensive care unit in Egypt. The Turkish journal of pediatrics. 2018;60(6):691-701.
  20. Caraballo C, Jaimes F. Focus: Death: Organ Dysfunction in Sepsis: An Ominous Trajectory From Infection To Death. The Yale journal of biology and medicine. 2019;92(4):629.
  21. Dunachie S, Chamnan P. The double burden of diabetes and global infection in low and middle-income countries. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2019;113(2):56-64.
  22. Hodgson K, Morris J, Bridson T, Govan B, Rush C, Ketheesan N. Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections. Immunology. 2015;144(2):171-85.
  23. van Vught LA, Holman R, de Jonge E, de Keizer NF, Van der Poll T. Diabetes is not associated with increased 90-day mortality risk in critically ill patients with sepsis. Critical care medicine. 2017;45(10):e1026-e35.
  24. Kim J, Kim YA, Hwangbo B, Kim MJ, Cho H, Hwangbo Y, et al. Effect of antihypertensive medications on sepsis-related outcomes: a population-based cohort study. Critical care medicine. 2019;47(5):e386-e93.
  25. Dial S, Nessim SJ, Kezouh A, Benisty J, Suissa S. Antihypertensive agents acting on the renin-angiotensin system and the risk of sepsis. British Journal of Clinical Pharmacology. 2014;78(5):1151-8.
  26. Chen C, Zhang Z, Li Z, Zhang F, Peng M, Chen Y, et al. Losartan attenuates microvascular permeability in mechanical ventilator-induced lung injury in diabetic mice. Molecular biology reports. 2014;41(2):809-14.
  27. Semeraro F, Colucci M, Caironi P, Masson S, Ammollo CT, Teli R, et al. Platelet drop and fibrinolytic shutdown in patients with sepsis. Critical care medicine. 2018;46(3):e221-e8.
  28. Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. Journal of intensive care. 2013;1(1):1-10.
DOI: https://doi.org/10.2478/jccm-2023-0005 | Journal eISSN: 2393-1817 | Journal ISSN: 2393-1809
Language: English
Page range: 30 - 38
Submitted on: Apr 19, 2022
Accepted on: Jan 14, 2023
Published on: Feb 8, 2023
Published by: University of Medicine, Pharmacy, Science and Technology of Targu Mures
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2023 Fazal Rehman, Saad Bin Zafar, Adil Aziz, Abdul Aziz, Pirbhat Shams Memon, Taymmia Ejaz, Summaira Aziz, published by University of Medicine, Pharmacy, Science and Technology of Targu Mures
This work is licensed under the Creative Commons Attribution 4.0 License.