Fig. 1
Fig. 2
Demographic, baseline, and laboratory characteristics of patients at hospital admission_
| Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | |
|---|---|---|---|---|---|
| Demographic and baseline characteristics | |||||
| Age, years | 68 | 62 | 41 | 64 | 96 |
| Gender | Male | Male | Female | Female | Male |
| BMI (kg/m2) | 31.8 | 28.2 | 30.18 | 35.34 | 28.74 |
| The severity of COVID-19 at admission | Negative | Mild | Moderate | Moderate | Mild |
| Previous illnesses | HTN, D.M., and CHF | DM | Asthma | HTN, hypothyroid- ism, breast cancer | HTN, COPD, CAD, D.M., HLD |
| Anti-thrombotic use at baseline | |||||
| Anticoagulants | No | No | No | No | Yes |
| Anti-platelet drugs | No | No | No | Yes | No |
| Time from symptom onset to start of treatment (days) | 13 days | 2 days | 14 days | 5 days | 1 day |
| Symptoms | Exertional dyspnoea and orthopnoea | Fever, cough, and fatigue | Shortness of breath and pro- ductive cough | Shortness of breath and tachypnea | Functional decline |
| Vital signs on Day 1 of admission | |||||
| Temperature (°F) | 98.7 | 102.4 (fever) | 98.6 | 98.8 | 97.9 |
| Respiratory rate (breaths per min) | 17 | 20 | 24 | 18 | 20 |
| Oxygen saturation on room air | 98% | 97% | 89% | 97% | 100% |
| Blood pressure (mm Hg) | 109/77 | 144/88 | 96/65 | 138/66 | 148/88 |
| Heart rate (beats per min) | 95 | 69 | 103 | 76 | 76 |
| Laboratory findings on Day 1 of | admission | ||||
| White blood cell count (x109 cells per L) | 10.95 | 5.13 | 6.3 | 7.98 | 7.1 |
| Lymphocyte count (109 cells per L) | 1.55 | 1.09 | 0.6 | 0.44 | 0.73 |
| Neutrophil count (109 cells per L) | 8.52 | 3.65 | 5.4 | 6.74 | 5.23 |
| The neutrophil-to-lympho- cyte ratio (NLR) | 5.49 | 3.35 | 9 | 15.32 | 7.16 |
| Haemoglobin (g/L) | 9.7 | 12.5 | 11.9 | 13.3 | 14.9 |
| Platelet count (109 per L) | 246 (Mini- | 119 (Mini- | 301 (Minimum: | 212 (Minimum: 82) | 238 (Minimum: |
| mum: 174) | mum: 68) | 41) | 203) | ||
| Creatinine (mg/dL) | 1.7 | 1.0 | 0.8 | 0.7 | 1.5 |
| C-reactive protein (mg/dL) | 3.4 (Peak: 9.8) | 2.7 (Peak: 9) | 15.2 (Peak: 16 | 2.3 (Peak: 16) | 7.5 (Peak: 10.44) |
| ESR (mm/hr) | 23 | 20 | 78 | 50 | 13 |
| LDH (U/L) | 174 (Peak: | 319 (Peak: | 406 (Peak: | 261 (Peak: 666) | 209 (Peak: 340) |
| 519) | 498) | 1316.6) | |||
| Ferritin (ng/mL) | 214.9 (Peak: | 234.9 (Peak: | 338.1 (Peak: | 183.2 (Peak: 218.2) | 60 (Peak: 123.5) |
| 455.9) | 1506.5) | 1506.5) | |||
| D-dimer (ng/mL) | 268 (Peak: | 367 (Peak: | 2506 (Peak: | 306 (Peak: 878) | 708 (Peak: 3480) |
| 4201) | 4081) | 5199) | |||
| Procalcitonin (ng/mL) | 0.2 | NA | 0.2 | 0.61 | 0.26 |