Demographics and para clinical characteristics of 156 enrolled COVID-19 patients_
| Group 1 . (n=98) | Group 2. (n=58) | p-value | |
|---|---|---|---|
| Complete blood count | |||
| Haemoglobin (g/dL) mean (SD) | 13.74 (1.5) | 13.32 (2.65) | Student t test p= 0.377 |
| Platelet count (103/uL) mean (SD) | 212.71 (80.32) | 265.77(13.05) | Student t test p =0.035 indicates a significant difference |
| Leukocyte count (/uL) mean (SD) | 6310.69 (2603.41) | 8867.69(5205.24) | Student t test p= 0.003 indicates a significant difference |
| Renal function tests | |||
| Urea (mg/dL) mean (SD) | 36.49 (15.36) | 57.66 (23.59) | Student t test p= 0.007 indicates a significant difference |
| Creatinine (mg/dL) mean (SD) | 0.85 (0.21) | 0.89 (0.24) | Student t test p= 0.592 |
| Electrolyte count | |||
| Sodium(mmol/L) mean (SD) | 138.73 (3.43) | 137.15 (4.88) | Student t test p= 0.135 |
| Potassium(mmol/L) mean (SD) | 4.33 (0.5) | 4.41 (0.74) | Student t test p= 0.603 |
| Biochemical tests | |||
| Glycaemia (mg/dL) mean (SD) | 118.59 (51.92) | 166.23 (87.71) | Student t test p= 0.004 indicates a significant difference |
| Albumin (g/L) mean (SD) | 3.11 (0.36) | 3.22 (0.73) | Student t test p= 0.574 |
| Cholesterol (mg/dL) mean (SD) | 182.16(49.27) | 200.43 (46.17) | Student t test p= 0.364 |
| Triglycerides (mg/dL) mean (SD) | 139(70.79) | 247.29 (171.41) | Student t test p= 0.005 |
| Inflammatory response markers | |||
| CRP (mg/dL) mean (SD) | 4.7 (5.47) | 7.81 (7.93) | Student t test p= 0.065 |
| Ferritin (ng/mL) mean (SD) | 929.17 (982.6) | 2597.677 (2233.74) | Student t test p= 0.02 indicates a significant difference |
| ICU | |||
| Length of stay in ICU. mean (SD) | 13.85(9.52) | 8.05(5.43) | Student t test p= 0.009 indicates a significant difference |
| Death (Y/N) | 26/72 | 35/23 | Mann Whitney U test p= 0.57 |
Forms of SARS-COV2 associated liver disease
| A mild form of the disease: Mild symptoms without clinical or para clinical signs of pneumonia, or with a Chest X-Ray or CT scan showing < 25% parenchymal damage. |
| A moderate form of the disease: Mild to moderate symptoms with para clinical signs of pneumonia, or a Chest X-Ray or CT scan showing a 25-50% parenchymal damage. |
| A severe form of the disease: With a respiratory rate ≥ 30/min, pS02 ≤ 93%, PaO2/FiO2 ≤ 300 mm Hg, or a Chest X-Ray or CT scan showing more than 50% parenchymal damage, or signs of acute respiratory distress, confusion/coma, sepsis, shock. |
Classification of liver injury
| Mild: Liver function tests 3-5 upper limit of normal. |
| Moderate: Liver function tests 5-10 upper limit of normal. |
| Severe: Liver function tests ≥ 10 |
Classification of the pattern of liver injury_
| Hepatocellular pattern: Alanine transaminase levels ≥ 5 upper limit of normal; alanine transaminase levels/alkaline phosphatase levels ≥ 5. |
| Cholestatic pattern: Alanine transaminase levels ≥ 2 upper limit of normal; alanine transaminase levels /alkaline phosphatase ≤2. |
| Mixed pattern: Alanine transaminase levels/alkaline phosphatase 2-5. |