Fig. 1
Protocol for bolus and dose adjustment when using UFH on CRRTModified unfractionated weight-based heparin nomogramTarget: aPTT x2 Initial Dose (Bolus) 50 UI/Kg * Maintenance 10 - 15 UI/Kg/H
| Plasma aPTT found | Continuous rate action | Bolus | Check time |
|---|---|---|---|
| Plasma aPTT <35 sec | + 4 UI/Kg/h | Rebolus 50 UI/Kg | aPTT afte (3h) |
| Plasma aPTT 35 - 45 sec | + 2 UI/Kg/h | Rebolus 20 UI/Kg | aPTT after (3h) |
| Plasma aPTT 46 - 60 sec | + 2 UI/Kg/h | - | aPTT after (3h) |
| Plasma aPTT 60 - 70 sec | - | - | aPTT after (4h) |
| Plasma aPTT 71 - 90 sec | - 2 UI/Kg/h | - | aPTT after (3h) |
| Plasma aPTT > 90 sec | - 3 UI/Kg/h | Stop Cont. inf 60 min | aPTT after (2h) |
Correlations and Descriptive Statistics depending on artery ageaPTT values for patients with Artery younger than 3 days ---- (n=45)
| Variables (sec.) | 1 | 2 | 3 | 4 | |
|---|---|---|---|---|---|
| 1 | CVC | - | 0.80 (r) | 0.71 (r) | 0.75 (r) |
| 2 | Access | 0.80 (r) | - | 0.62 (r) | 0.67(r) |
| 3 | Postfilter | 0.71 (r) | 0.62 (r) | - | 0.57(r) |
| 4 | Artery | 0.75 (r) | 0.67 (r) | 0.57 (r) | |
| aPTT values for patients with Artery age between 4 to 6 days---- (n=39) | |||||
Correlations and Descriptive Statistics (N = 84) - aPTT values for CVC, Access, Postfilter and Artery
| Variables | 1 | 2 | 3 | 4 | |
|---|---|---|---|---|---|
| 1 | CVC (sec.) | - | 0.72 (r) | 0.69 (r) | 0.46 (r) |
| 2 | Access (sec.) | 0.72 (r) | - | 0.62 (r) | 0.43 (r) |
| 3 | Postfilter (sec.) | 0.69 (r) | 0.62 (r) | - | 0.47 (r) |
| 4 | Artery (sec.) | 0.46 (r) | 0.43 (r) | 0.47 (r) | - |
Comparison of CVC, Access, Postfilter and Artery aPTT values
| Section A | All patients group (84) | Mean (SD) | p value | |
|---|---|---|---|---|
| Access (sec.) | 73 (±20) | p = 0.74 | ||
| Posftilter (sec.) | 92 (±19) | p < 0.01 | 75 (±18) | |
| Artery (sec.) | 82 (±18) | p < 0.01 | ||