Fig. 1
Results of the Cox regression analysis_
| Variable | AHR | 95% IC | P |
|---|---|---|---|
| Serum lactate | 1,28 | 1,07-1,53 | 0,008 |
| APACHE II | 1,07 | 1,00-1,14 | 0,06 |
| SOFA | 0,96 | 0,89-1,03 | 0,258 |
| Excess Base | 1,02 | 0,97-1,07 | 0,417 |
Analytical values and physiological variables in the first six hours after admission to the ICU_
| Variable | Serum lactate >2 mmol/l (N= 80) | Serum lactate ≤ 2 mmol/l (N= 65) | P |
|---|---|---|---|
| Leukocytes / mm3, median (IQR **) | 12,5 (8,7-18,9) | 11,6 (8,5-14,3) | 0,055 |
| Hematocrit (%), median (IQR **) | 31,2 (5,8) | 32 (8,3) | 0,482 |
| Platelet count / mm3, median (IQR **) | 200 (164,3-279,0) | 200 (170,0-239,0) | 0,510 |
| Blood Glucose (mmol/l), median (IQR **) | 7,2 (5,9-8,9) | 6,8 (58,7-9,6) | 0,066 |
| Aminotransferase Aspartate (u/l), median (IQR **) | 42,5 (29,3-75,6) | 41,0 (31,5-69,5) | 0,469 |
| Aminotransferase Alanine (u/l), median (IQR **) | 40,0 (28,3-60,0) | 40,0 (29,0-58,0) | 0,124 |
| Albumin (g/l), median (IQR **) | 33,0 (27,3-37,0) | 35,0 (28,0-38,0) | 0,164 |
| Creatinine (Mmol / l), median (IQR **) | 90,5 (66,3-129,5) | 86 (68,5-114,0) | 0,044 |
| PH, median (IQR **) | 7,41 (7,35-7,45) | 7,42 (7,37-7,45) | 0,225 |
| PCO2 (mmHg), median (IQR **) | 35,3 (21,1-42,8) | 35,0 (30,1-42,6) | 0,08 |
| PO2 (mmHg), median (IQR **) | 86,5 (70,0-115,3) | 90,0(72,9-115,0) | 0,175 |
| Base Excess, median (IQR **) | -0,7 (-4,1-2,6) | -0,1 (-3,6-2,2) | 0,341 |
| Bicarbonate, median (IQR **) | 23,4 (20,9-26,0) | 24,0 (19,9-26,3) | 0,407 |
| PO2 / FiO2, average (SD *) | 306,9 (137,8) | 341,5 (117,9) | 0,232 |
| D(A-a)O2, median (IQR **) | 81,0 (29,2-140,6) | 56,6 (17,5-97,7) | 0,241 |
| Sodium (mmol / l), median (IQR **) | 136,0 (132,0-141,0) | 133,0 (130,0-138,5) | 0,056 |
| Potassium (mmol / l), median (IQR **) | 3,8 (3,4-4,2) | 3,7 (3,4-4,2) | 0,845 |
| Heart Rate (bpm), average (SD *) | 93,9 (21,0) | 97,3 (18,5) | 0,374 |
| Respiratory rate (rpm), median (IQR **) | 22,0 (19,0-25,8) | 21,0 (20,0-25,0) | 0,252 |
| Medium Arterial Tension (mmHg), median (IQR **) | 92,3 (82,1-99,8) | 93 (80,5-102,2) | 0,021 |
General characteristics of the population, stratified according to serum lactate values in the first six hours after admission to the ICU_
| Variable | Serum lactate >2mmol/ (N=80) | Serum lactate ≤ 2mmol/l (N=65) | P |
|---|---|---|---|
| Age, average (SD) | 53,9 (16,8) | 45,1 (17,6) | 0,203 |
| Sex, n (%) | |||
| Male | 46 (57,5) | 26 (40,0) | 0,860 |
| Female | 34 (42,5) | 39 (60,0) | |
| Apache II, median (IQR **) | 14 (11,0-20,0) | 8 (5,0-13,0) | 0,002 |
| SOFA, median (IQR **) | 10,5 (6,0-15,0) | 5 (1,5-8,0) | 0,098 |
| Cause of admission to the ICU, n (%) | |||
| Cardiovascular | 8 (10,0) | 1 (1,5) | 0,520 |
| Pulmonary | 6 (7,5) | 7 (10,8) | 0,463 |
| Neurological | 6 (7,5) | 5 (7,7) | 0,691 |
| Traumatic | 26 (32,5) | 19 (29,2) | 0,05 |
| Infectious | 16 (20,0) | 11 (16,9) | 0,041 |
| Gastrointestinal | 8 (10,0) | 8 (12,3) | 0,738 |
| Poisoning | 1 (1,3) | 4 (6,2) | 0,583 |
| Other | 9 (11,3) | 10 (15,4) | 0,124 |
| Hemodynamic support, n (%) | 14 (17,5) | 4 (6,2) | 0,008 |
| Use Mechanical Ventilation, n (%) | 25 (31,3) | 21(32,3) | <0,0001 |
| Stay in ICU, median (IQR **) | 5,0 (4,0-7,0) | 6,0 (4,0-7,5) | 0,756 |