References
- Amin A, Hamza AA, Daoud S, Khazanehdari K, Hrout AA, Baig B, Chaiboonchoe A, Adrian TE, Zaki N, Salehi-Ashtiani K. (2016). Saffron-Based Crocin Prevents Early Lesions of Liver Cancer: In vivo, In vitro and Network Analyses. Recent Pat Anticancer Drug Discov11: 121–133.
- Assimopoulou AN, Sinakos Z, Papageorgiou VP. (2005). Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytother Res19: 997–1000.
- Ben Salem I, Boussabbeh M, Kantaoui H, Bacha H, Abid-Essefi S. (2016). Crocin, the main active saffron constituent, mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells. Biomed Pharmacother82: 65–71.
- Benzie IF, Strain JJ. (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem239: 70–76.
- Berger F, Hensel A, Nieber K. (2011). Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. Neuroscience180: 238–247.
- Blajeski AL, Phan VA, Kottke TJ, Kaufmann SH. (2002). G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. J Clin Invest110: 91–99.
- Das I, Das S, Saha T. (2010). Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study. Acta Histochem112: 317–327.
- Das I, Chakrabarty RN, Das S. (2004). Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice. Asian Pac J Cancer Prev5: 70–76.
- El-Beshbishy HA, Hassan MH, Aly HA, Doghish AS, Alghaithy AA. (2012). Crocin “saffron” protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes. Ecotoxicol Environ Saf83: 47–54.
- el Saghir NS, Hawkins KA. (1984). Hepatotoxicity following vincristine therapy. Cancer54: 2006–2008.
- Fossati P, Ponti M, Prencipe L, Tarenghi G. (1989). One-step protocol for assays of total and direct bilirubin with stable combined reagents. Clin Chem35: 173–176.
- Geyp M, Ireland CM, Pittman SM. (1996). Resistance to apoptotic cell death in a drug resistant T cell leukaemia cell line. Leukemia10: 447–455.
- Ghaffari S, Hatami H, Dehghan G. (2015). Saffron ethanolic extract attenuates oxidative stress, spatial learning, and memory impairments induced by local injection of ethidium bromide. Res Pharm Sci10: 222–232.
- Gidding CE, Kellie SJ, Kamps WA, de Graaf SS. (1999). Vincristine revisited. Crit Rev Oncol Hematol29: 267–287.
- Harrington M. (2011). Saffron offers protection from liver cancer. Lab Animal40: 289.
- He SY, Qian ZY, Tang FT, Wen N, Xu GL, Sheng L. (2005). Effect of crocin on experimental atherosclerosis in quails and its mechanisms. Life Sci77: 907–921.
- Hosseini A, Mousavi SH, Ghanbari A, Homaee Shandiz F, Raziee HR, Pezeshki Rad M, Mousavi SH. (2015). Effect of saffron on liver metastases in patients suffering from cancers with liver metastases: A randomized, double blind, placebo-controlled clinical trial. Avicenna J Phytomed5: 434–440.
- Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. (2005). Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. J Pharm Pharm Sci8: 387–393.
- Chahine N, Makhlouf H, Duca L, Martiny L, Chahine R. (2014). Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury. Z Naturforsch C J Biosci69: 459–470.
- Jordan MA, Thrower D, Wilson L. (1992). Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. J Cell Sci102 ( Pt 3): 401–416.
- Kamalipour M, Akhondzadeh S. (2011). Cardiovascular effects of saffron: an evidence-based review. J Tehran Heart Cent6: 59–61.
- Koul A, Abraham SK. (2017). Intake of saffron reduces gamma-radiation-induced genotoxicity and oxidative stress in mice. Toxicol Mech Methods27: 428–434.
- Kumar A, Patil D, Rajamohanan PR, Ahmad A. (2013). Isolation, purification and characterization of vinblastine and vincristine from endophytic fungus Fusarium oxysporum isolated from Catharanthus roseus. PloS One8: e71805.
- Mahmoudzadeh L, Najafi H, Ashtiyani SC, Yarijani ZM. (2017). Anti-inflammatory and protective effects of saffron extract in ischaemia/reperfusion-induced acute kidney injury. Nephrology22: 748–754.
- Martins DB, Lopes STA, Mazzanti CM, Spanevello R, Schmatz R, Corrêa M, Stefanello N, Schetinger MR, Morsch V, Veiga APM. (2011). Lipid peroxidation in rats treated with vincristine sulphate and nandrolone decanoate. Arq Bras Med Vet Zootec63: 107–113.
- Mashmoul M, Azlan A, Khaza’ai H, Yusof BN, Noor SM. (2013). Saffron: A Natural Potent Antioxidant as a Promising Anti-Obesity Drug. Antioxidants2: 293–308.
- Mashmoul M, Azlan A, Mohtarrudin N, Mohd Yusof BN, Khaza’ai H, Khoo HE, Farzadnia M, Boroushaki MT. (2016). Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats. BMC Complement Altern Med16: 401.
- Nair SC, Kurumboor SK, Hasegawa JH. (1995). Saffron chemoprevention in biology and medicine: a review. Cancer Biother10: 257–264.
- Nevalainen TJ. (1975). Cytotoxicity of vinblastine and vincristine to pancreatic acinar cells. Virchows Arch B Cell Pathol18: 119–127.
- Ogunc Y, Demirel M, Yakar A, Incesu Z. (2017). Vincristine and varepsilon-viniferine-loaded PLGA-b-PEG nanoparticles: pharmaceutical characteristics, cellular uptake and cytotoxicity. J Microencapsul34: 38–46.
- Omidi A, Riahinia N, Montazer Torbati MB, Behdani MA. (2014). Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats. Avicenna J Phytomed4: 330–336.
- Pan TL, Wu TH, Wang PW, Leu YL, Sintupisut N, Huang CH, Chang FR, Wu YC. (2013). Functional proteomics reveals the protective effects of saffron ethanolic extract on hepatic ischemia-reperfusion injury. Proteomics13: 2297–2311.
- Premkumar K, Abraham SK, Santhiya ST, Ramesh A. (2003). Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother Res17: 614–617.
- Samarghandian S, Azimi-Nezhad M, Farkhondeh T. (2017). Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats. Indian Heart J69: 151–159.
- Samarghandian S, Azimi-Nezhad M, Samini F. (2014). Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. Biomed Res Int2014: 920857.
- Shati AA, Alamri SA. (2010). Role of saffron (Crocus sativus L.) and honey syrup on aluminum-induced hepatotoxicity. Saudi Med J31: 1106–1113.
- Schrek R, Stefani SS. (1976). Inhibition by ionophore A23187 of the cytotoxicity of vincristine, colchicine and X-rays to leukemic lymphocytes. Oncology33: 132–135.
- Silverman JA, Deitcher SR. (2013). Marqibo(R) (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine. Cancer Chemother Pharmacol71: 555–564.
- Takano Y, Okudaira M, Harmon BV. (1993). Apoptosis induced by microtubule disrupting drugs in cultured human lymphoma cells. Inhibitory effects of phorbol ester and zinc sulphate. Pathology, research and practice189: 197–203.
- Tavilani H, Doosti M, Saeidi H. (2005). Malondialdehyde levels in sperm and seminal plasma of asthenozoospermic and its relationship with semen parameters. Clin Chim Acta356: 199–203.
- Thakur V, Kush P, Pandey RS, Jain UK, Chandra R, Madan J. (2016). Vincristine sulfate loaded dextran microspheres amalgamated with thermosensitive gel offered sustained release and enhanced cytotoxicity in THP-1, human leukemia cells: In vitro and in vivo study. Mater Sci Eng C Mater Biol Appl61: 113–122.
- van Tellingen O, Sips JH, Beijnen JH, Bult A, Nooijen WJ. (1992). Pharmacology, bio-analysis and pharmacokinetics of the vinca alkaloids and semi-synthetic derivatives (review). Anticancer Res12: 1699–1715.
- Verma SK, Bordia A. (1998). Antioxidant property of Saffron in man. Indian J Med Sci52: 205–207.